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M Rees

Publications and source records attributed to M Rees.

At least 163 records · Page 9Linked to original sources
PubMed1978

Prophylaxis against systemic infection after transrectal biopsy for suspected prostatic carcinoma.

Five minutes after transrectal prostatic biopsy 16 out of 21 patients were shown by blood culture to have bacteraemia. Antibiotic prophylaxis--routinely with ampicillin and metronidazole for 48 hours--prevented progression to septicaemia, and four days after the procedure all blood samples were negative. Irrespective of whether antibiotic prophylaxis is used, blood culture should be routine in all patients undergoing transrectal prostatic biopsy.

Ampicillin↗
PubMedDate not supplied

The sombre view of AIDS.

Extrapolation from short-term data is risky, but the development of AIDS among those infected with HIV by blood transfusions, if properly described by a normal distribution, suggests a 15-year mean incubation and a high incidence of disease among carriers of the virus.

Acquired Immunodeficiency Syndrome↗
PubMedDate not supplied

Coughs and colds: nurse management of upper respiratory tract infection.

BACKGROUND: Nurses in general practice are increasingly managing minor illness. This literature review examines the management of upper respiratory tract infection (URTI) as one area of patient care where nurses can make a major contribution. CONCLUSION: The challenge for nurses is to respond to the changing healthcare environment creatively and in collaboration with doctors and patients.

Anti-Bacterial Agents↗
PubMedDate not supplied

Current status of surgery in colorectal metastases to the liver.

The prime role of hepatic resection in the management of colorectal cancer metastatic to the liver is firmly established. The evolution of surgical and anaesthetic techniques has dramatically reduced the morbidity and mortality of elective liver resection in the hands os specialist hepatobiliary surgical teams. At least a third of patients who undergo liver resection for colorectal metastases can expect to survive five years. Although only 10-20% of all patients presenting with colorectal liver metastases are suitable for surgery, novel strategies such as portal vein embolisation and downstaging chemotherapy promise to increase the proportion of eligible patients.

Colorectal Neoplasms↗
PubMedDate not supplied

The prognostic significance of proliferative activity, apoptosis and expression of DNA topoisomerase II alpha in multimodally-treated oesophageal squamous cell carcinoma.

The present study retrospectively examined the correlation between the outcome of patients with locally advanced oesophageal squamous cell carcinoma (cT3-4 cN0-1 cM0) after multimodal treatment (radiochemotherapy +/- surgical resection) and the parameters proliferative activity, apoptotic index and expression of the nuclear enzyme topoisomerase II alpha (topo II alpha) in pre-therapeutic tumour biopsies. Fifty-eight patients who took part in a prospective multicentred trial received radiochemotherapy, optionally followed by surgery. Pre-therapeutic biopsies were immunohistochemically investigated for the extent of proliferation (MIB-I index) and expression of the topo II alpha-enzyme. The apoptotic index was determined by the TUNEL-assay. The three parameters were correlated with tumour response to polychemotherapy and with overall survival. Topo II alpha expression was found in all samples with different percentages of positive cells. The proliferation indices ranged between 9% and 97% (median: 43%) while the apoptotic indices ranged between 0.2% and 2.8% (median: 0.5%). Strong expression of topo II alpha (>50% positive tumour cells) was positively-correlated with response to polychemotherapy (p=0.016) whereas proliferative activity or apoptotic index showed no impact. None of the three parameters under investigation was predictive of overall survival. Pre-therapeutic determination of topo II alpha expression may predict chemosensitivity of oesophageal squamous cell carcinomas. However, determination of proliferative activity and apoptotic index has no predictive value.

Antigens, Neoplasm↗