PubMed Health⌕ Search

Biomedical subjects

M Rees

Publications and source records attributed to M Rees.

At least 145 records · Page 8Linked to original sources
PubMed1987

Menorrhagia.

Explore the source record for details and available documents.

Adult↗
PubMed1986

Rapid-acquisition computed tomography demonstration of chronic calcified pericardial constriction.

Dynamic imaging by a new ultrafast computed tomography scanner of a patient with chronic calcified pericardial constriction is presented. Images of the heart throughout the cardiac cycle demonstrate compression of the right ventricle by calcified pericardium. Hemodynamic data was derived from the scan study to support the diagnosis of pericardial constriction, which was confirmed on cardiac catheterization.

Aged↗
PubMed1986

Mild androgen insensitivity presenting with sexual dysfunction.

A man presented with sexual dysfunction and was found to have elevated serum levels of both gonadotropins and T, suggesting AIS. Small external genitalia were the only phenotypic abnormality. Serum T levels increased appropriately in response to hCG and CC, but the patient was severely oligospermic, and testicular biopsy study revealed profoundly impaired spermatogenesis. Studied on androgen receptors in genital skin fibroblasts were normal. PAIS with a virtually normal male phenotype can present in adulthood with sexual dysfunction as well as infertility. As with the syndrome of complete AIS, androgen receptor studies indicate that this is a heterogeneous group of disorders.

Adult↗
PubMed1986

The functional and anatomic evaluation of the cardiovascular system with rapid-acquisition computed tomography (cine CT).

Cine CT combines the advantages of digital cross-sectional imaging with those of angiography. It provides vivid portrayal of complex anatomic relationships as well as important functional data not easily obtainable elsewhere, including quantitation of myocardial wall thickening and regional myocardial blood flow. The blood flow in major vessels following coronary artery bypass graft surgery and cardiac output have been quantified with accuracy. The future of cine CT will depend ultimately on controlled studies comparing this technique with other modalities, including echocardiography, magnetic resonance imaging, radionuclide angiocardiography, and contrast-enhanced catheter angiography.

Blood Flow Velocity↗
PubMed1984

Hemodynamic response to naloxone during live Escherichia coli sepsis in splenectomized dogs.

This study was designed to investigate the concept that endogenous opioids are involved in the pathogenesis of septic shock. Infusion of live Escherichia coli (1.0-1.6 X 10(10) organisms/kg) in splenectomized dogs induced profound hypotension (p less than 0.001), peripheral vasodilatation (p less than 0.001), and metabolic acidosis (p less than 0.05) with maintenance of cardiac index as compared to control splenectomized dogs. Treatment with naloxone (3 mg/kg bolus and 2 mg/kg/hr infusion for 2.5 hours), a specific opiate antagonist, during septic shock attenuated the hypotension (p less than 0.002) and systemic acidosis (p less than 0.02) without altering cardiac index or total peripheral resistance. These experimental results indicate that naloxone may be of therapeutic value in the management of the early vasodilatory stage of septicemia.

Animals↗
PubMed1983

Dog bites of the face: a 15 year review.

Over a period of 15 years, 109 patients with 148 dog bites of the face were treated in one Plastic Surgery Unit. In this retrospective review the patterns of injury and treatment are defined with particular reference to specialised anatomical structures involved and the problems of repair. In this study, 87 patients (80%) were under 15 years of age.

Adolescent↗
PubMed1983

Plasma beta-endorphin immunoreactivity in dogs during anesthesia, surgery, Escherichia coli sepsis, and naloxone therapy.

To improve understanding of the role of endorphins in septic shock, we examined the effects of anesthesia, splenectomy, live Escherichia coli infusion, and treatment with naloxone, respectively, on plasma beta-endorphin immunoreactivity (beta-EI) and plasma cortisol in dogs. Baseline levels of plasma beta-EI and cortisol were established in awake dogs. Pentobarbital anesthesia alone did not affect plasma beta-EI, but splenectomy was followed by a significant (P less than 0.001) rise in both plasma beta-EI and cortisol. Infusion of saline over a 3-hour period following splenectomy induced no further increase in plasma beta-EI, but infusion of live E. coli in splenectomized dogs caused a further rise in plasma beta-EI (P less than 0.02). Following induction of septic shock in a separate group of splenectomized animals, treatment with naloxone (3 mg/kg bolus and 2 mg/kg/hr infusion) did not alter the rise in plasma beta-EI. These results confirm release of beta-endorphin during septic shock and further implicate the hypothalamic-pituitary-adrenal axis in its pathophysiology. Based on the finding that naloxone did not affect the dynamics of plasma beta-EI, mechanisms are postulated to explain the therapeutic value of this drug in septic shock.

Anesthesia↗
PubMed1982

Stress ulcers during live Escherichia coli sepsis. The role of acid and bile.

This study was designed to define the conditions that will consistently produce stress ulcers following the systemic infusion of live E. coli (1.0-1.6 X 10(10) organisms/kg/hr). Using gold-filled oxygen microelectrodes and the in vivo gastric chamber model in dogs, the authors found that the intracellular oxygen tension of the superficial gastric epithelium declined during sepsis despite maintenance of total gastric blood flow. This hypoxia persisted for the three-hour experiment when normal saline bathed the gastric surface (n = 6). Adding 1-mM taurocholate (Tc) (n = 6) or 80-mM hydrochloric acid (HCl) (n = 6) to the gastric chamber improved the cellular hypoxia induced by sepsis, and no ulcers were produced. However, addition of physiologic concentrations of bile in acid (1-mM Tc in 80-mM HCl) produced widespread ulceration of the mucosa within 30 minutes in nine of ten dogs. These experiments demonstrate that epithelial hypoxia induced by sepsis predisposes the gastric mucosa to ulcerate in the presence of physiologic concentrations of topical acid and bile.

Animals↗
PubMed1982

Naloxone reverses tissue effects of live Escherichia coli sepsis.

Hypoxia of the superficial gastric epithelium induced by a systemic infusion of live Escherichia coli organisms was mimicked by a local intra-arterial infusion of the naturally occurring opiate beta-endorphin. Naloxone, a specific opiate antagonist, reversed the gastric epithelial hypoxia induced by sepsis and also prevented the development of systemic acidosis. The mean blood pH of septic dogs had declined during the experiment from 7.42 +/- 0.06 to 6.88 +/- 0.17, whereas corresponding values for the naloxone-treated group were 7.38 +/- 0.06 and 7.32 +/- 0.08. These experiments, which support the concept of beta-endorphin involvement in the pathogenesis of septic shock, indicate a direct tissue response to circulatory beta-endorphin and highlight a further beneficial effect of naloxone in the management of sepsis.

Animals↗