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Biomedical subjects

M Rosnowska

Publications and source records attributed to M Rosnowska.

At least 19 recordsLinked to original sources
PubMed1997

[Leukotrienes B4 and C4 in cerebrospinal of patients with multiple sclerosis].

Leukotrienes B4 and C4 have been assayed in CSF of 24 patients with the attacks or slowing-progressing course of multiple sclerosis, and in 23 patients with other noninflammatory diseases. Leukotrienes concentrations have been assayed with RIA technique with the use of commercially available kits manufactured by Amersham. Leukotrienes B4 and C4 levels in CSF of patients with multiple sclerosis have been 91.8 +/- 5.6, and 88.6 +/- 7.5 pg, and have been significantly higher than those in other neurological disorders (p < 0.01). Mean LTB4 and LTC4 levels have been significantly lower in patients with atherosclerotic dementia (69, 12.2 and 63, 02.9 pg/ml) or in patients with headache (72.7 +/- 2.8 and 64.5 +/- 8.2 pg/ml). Higher LTB4 and LTC4 levels in patients with multiple sclerosis is probably due to both increased penetration through blood-brain barrier and their synthesis in blood-brain barrier, and cerebral nervous tissue. Further investigations are necessary to show whether LTB4 and LTC4 levels may indicate a stage of inflammatory process activity and enable to draw any conclusions on efficacy of anti-inflammatory therapy.

Blood-Brain Barrier↗
PubMed1989

[Free fatty acids in the serum of patients with alcoholism].

Blood free fatty acids and their composition were investigated in 25 alcohol abusers hospitalized for detoxication. Blood samples were collected at the admission to the hospital and following detoxication therapy. Free fatty acids were assayed with Dole's technique whereas their composition with gas chromatography. Liver functioning was evaluated with the aid of the following tests: AspAT, AlAT, AP, bilirubin concentration, and thymol test. An increase in free fatty acids concentration was seen in 12 out of 25 patients prior to detoxication. Blood serum free fatty acids were within normal limits in all except one patient after detoxication. A decrease in linoleic acid levels was seen in both total fatty acids and free fatty acids before detoxication. It is more marked in total fatty acids than in free fatty acids and persists after detoxication. Linoleic acid content in free fatty acids returns to the normal values following detoxication. An increase in oleic acid level accompanying a decrease in linoleic acid concentration is probably secondary to the stimulation with hydrogen excess formed during alcohol fermentation.

Adult↗
PubMed1978

[Blood levels of phenytoin and phenobarbital in epileptics treated with phenydantin and phenytoinum].

In 80 epileptics receiving Phenydantin or Phenytoinum the blood levels of phenytoin and phenobarbital were determined. In all, 160 determinations of phenytoin (PHT) and 120 determinations of phenobarbital (PB) were done. Drug levels were determined spectrophotometrically. In 7% of patients toxic concentrations of PHT and in 3% toxic concentrations of PB were found. The PHT level below the therapeutic one was found in 16% of cases, and PB in 23%. The results of this study point to the necessity of routine control of the levels of anticonvulsants in the blood.

Drug Synergism↗
PubMed1978

[Haptoglobin levels in the serum and the cerebrospinal fluid patients with multiple sclerosis].

In 47 patients with multiple sclerosis and 10 with other diseases of the nervous system determinations of haptoglobin were performed in the serum and cerebrospinal fluid by the method of Owen et al. The Hp level in the serum of multiple sclerosis patients was normal. Its level in the cerebrospinal fluid was higher in multiple sclerosis patients than in cases of other nervous system diseases (statistically significant difference, p less than 0.001). Raised value of the Hp/IgG index in the cerebrospinal fluid of multiple sclerosis patients points to increased permeability of the blood-brain barrier. The so called normal Hp/IgG index was found in multiple sclerosis patients with high Hp and IgG level. Low Hp/IgG index suggested the possibility of IgG synthesis in the brain of patients with this disease. The comparison of the protein level and protein indexes showed that raised IgG level in the cerebrospinal fluid was present in 80% of multiple sclerosis cases, raised Kabat index in 50%, and low Hp/IgG index in 48%.

Haptoglobins↗