The chloroform--induced renal tubular necrosis is associated with the rise of serum urea, creatinine and potassium. The highest values, observed 24 hours after chloroform administration, are respectively: 75 mg% (norm 32 mg%), 1.75 mg% (norm 0.25 mg%), 6.1 mEq/1 (norm 4.4 mEq/1). They gradually decreased with the progress of renal regeneration. These transient, rather little biochemical deviations justify the good conditions and eventual survival of chloroform-poisoned mice. The contribution of possible glomerular lesions to the disturbed renal function is taken into consideration.

Acute Kidney Injury↗

PubMedDate not supplied

[Evaluation of cerebrospinal fluid proteins in patients with subacute sclerosing panencephalitis (SSPE)].

CSF proteins of 62 patients with SSPE aged 6 to 26 years were analysed by polyacrylamide gel electrophoresis. The total IgG concentration in the CSF was increased to 16.8 +/- 10 mg/dl and the IgG index was raised to from 2.7 +/- 0.5 to 3.6 +/- 3.0. All SSPE patients had pathological subfractions gamma 4 and gamma 5. The per cent proportion of the gamma 1 subfraction was raised only in the youngest patients. A tendency was observed for higher values of the prealbumin:albumin index and the prealbumin: transferrin index. The youngest SSPE patients had a tendency for greater total protein concentration, lower prealbumin concentration, and highest IgG index values (3.6 +/- 3.0). In early disease period a tendency was noted for higher concentration of total protein, higher total IgG level and higher IgG index. These results suggest that SSPE patients have a constant stimulation of B-cells and variable increase of blood-brain barrier permeability.

Adolescent↗

PubMedDate not supplied

[Lipid peroxides in the sera of patients with multiple sclerosis].

Serum lipid peroxides (LPX) were determined in 24 patients with multiple sclerosis and in 30 healthy controls. Patients with relapses or chronic progression had significantly higher serum LPX level than healthy controls: mean 3.09 +/- 0.15 nmol/ml versus 2.30 nmol/ml, p less than 0.01. Relapsing-remitting patients showed slightly higher LPX level than slowly progressive patients. It is supposed that lipid peroxides are unspecific mediators of the inflammatory reaction in multiple sclerosis.

Adult↗

PubMedDate not supplied

[Serum levels of lipid peroxides in alcoholics].

Serum lipid peroxidases (LPx) concentration was assayed in the following groups: 25 patients with diagnosis of acute alcohol intoxication, 20 patients during alcohol abstinence and 30 healthy control individuals. In 25 patients the assessments were carried out twice: before and on the 3-7 day of detoxification. The serum LPx had been significantly higher in all patients during the acute intoxication period (4.33 +/- 0.20 nmol/l; p less than 0.01). In 38% of them the LPx concentration was falling down after detoxication. There were no difference in LPx concentration between the group of abstinents and the healthy controls. The results point to dependence between clinical state of alcoholics and serum LPx level.

Adult↗

PubMedDate not supplied

[Prostaglandins in the central nervous system].

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Adrenocorticotropic Hormone↗