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Biomedical subjects

M Rothe

Publications and source records attributed to M Rothe.

At least 73 records · Page 4Linked to original sources
PubMed1989

Three hormone receptor-like Drosophila genes encode an identical DNA-binding finger.

The putative finger domain of knirps (kni), a member of the gap class of segmentation genes, was used to isolate two sequence-related genes of Drosophila melanogaster under reduced stringency hybridization conditions. The two kni homologous genes map close to kni in the proximal portion of the third chromosome. One of them is the previously identified gene knirps-related (knrl), kni and knrl are spatially co-regulated in both early and late stages of embryogenesis. Their posterior domains of expression at blastoderm stage are under the control of the maternal pattern organizer gene nanos. In contrast, the expression of the second kni homologous gene is restricted to the late embryonic gonads. Due to its site of expression, we termed this gene 'embryonic gonad' (egon). In addition to the conserved DNA-binding domain, these three genes share an additional sequence of 19 amino acids, the kni-box, adjacent to the finger region. The identical N-terminal Cys/Cys finger encoded by each of the three genes suggests that they code for DNA-binding proteins which might bind to similar (or even identical) target sequences.

Amino Acid Sequence↗
PubMed1989

Malignant giant cell tumor of soft parts presenting as a skin tumor.

Malignant giant cell tumor of soft parts is a rare neoplasm that histologically resembles a giant cell tumor of bone. It has a distinctive multinodular growth pattern and is composed of numerous osteoclast-like giant cells, histiocytes, and fibroblasts. Although this tumor is usually found in deep soft tissues, a superficial form has been described in the subcutaneous tissue and fascia. The authors report two patients, aged 75 and 78, with malignant giant cell tumors presenting as ulcerating skin nodules of the arm and foot. The tumors were relatively small, measuring less than 3.5 cm in greatest dimension, and involved the entire dermis and subcutaneous tissue. The clinical differential diagnoses included Kaposi's sarcoma, melanoma, and hematoma. Dermatopathologists and dermatologists should be aware of this entity to avoid confusion with other benign and malignant neoplasms that may contain multinucleated giant cells. The distinguishing histologic and immunohistochemical features of this tumor are discussed.

Aged↗
PubMed1987

Antinuclear antibodies during psoralens plus ultraviolet A (PUVA) therapy--are they worthwhile?

From 1979 to 1985, 497 patients with psoriasis were started on psoralens plus ultraviolet A (PUVA) therapy at Northwestern University. Two hundred sixty-nine of these received therapy for greater than 3 months and had at least two antinuclear antibody (ANA) determinations. We have found that the difference between the number of significantly positive ANAs pre-PUVA therapy (4 of 269) compared to post-PUVA therapy (16 of 269) was not statistically significant. Furthermore, of the patients who did develop a significantly positive ANA, not one was found to have any symptoms, signs, or laboratory evidence of systemic lupus erythematosus. We therefore suggest obtaining ANAs prior to initiating PUVA therapy and obtaining follow-up ANAs only if the initial ANA is significantly positive. Patients with pre-PUVA--positive ANAs can be started on PUVA therapy if there is no evidence of lupus erythematosus.

Antibodies, Antinuclear↗
PubMed1983

Sensory characteristics of 2-heptanone. Part I. Threshold values, concentration/odour intensity relations, methodological aspects.

The evaluation of threshold values and concentration/odour intensity relations for 2-heptanone has been carried out in two laboratories applying strictly uniform materials, methods and laboratory procedures. The results obtained in aqueous and oil medium are discussed taking into consideration the influence of methods and judges as variability factors. It has been concluded that standardization of the methods and detailed laboratory procedure seem to be critical factors for inter-reproducibility of the results in various sensory laboratories.

Female↗
PubMed1983

Aroma retention in modern bread production.

In highly industrialized countries bread consumption rate decreases in favour of flavour-intensive foods like meat, sweets, cocoa products or alcoholic beverages. This trend which is unfavourable from the nutritional point of view may be forced by flavour losses in modern bread technology itself. Sensory profile studies indicate 4 points which may change the traditional bread flavour, i.e. reduction of flour extraction rate, changes within bread formula, shortening of the dough procedures or of baking time. Possible ways for improving bread flavour in modern technology are discussed. The use of precursor systems as well as of biotechnical procedures deliver chances for future bread production with improved flavour quality.

Bread↗
PubMed1983

Characterization of formaldehyde-related antibodies encountered in hemodialysis patients at different stages of immunization.

In hemodialysis patients who reuse formaldehyde-sterilized dialysers we found that antibodies agglutinating native NN red cells belonged exclusively to the IgM fraction of immunoglobulins. In the same patients antibodies directed against formaldehyde-altered NN red cells proved to be mainly IgG in addition to IgM. Three stages of formaldehyde-dependent RBC immunization could be distinguished serologically. The production of these antibodies was dependent on the time of hemodialysis treatment. We found antibodies which could bind complement in the presence of soluble antigen. These antibodies are supposed to damage the patient's red cells immediately after contact to minute amounts of formaldehyde during hemodialysis.

Blood Group Incompatibility↗
PubMed1980

[Hematological studies of boars during testing for breeding suitability].

Studies were conducted into haemoglobin and haematocrit levels as well as into mean corpuscular haemoglobin concentrations (MCHC) of venous blood samples which had been collected from 600 boars, aged between 180 and 200 days and weighing between 90 kg and 100 kg. The following values, per 100 millilitres of erythrocytes, were obtained: 13.36 +/- 1.06 g of haemoglobin, 42.16 +/- 3.3 per cent of haematocrit, and 31.74 +/- l.6 g of MCHC. Seven random samples were investigated, and the following values were beyond normal limits: 34.91 per cent of haemoglobin (22.22-44.91 per cent), 23.96 per cent of haematocrit (12.28-46.16 per cent), and 61.89 per cent of MCHC (35.08-78.94 per cent). The above results were compared with those which had been obtained from the same animals, when aged between 105 and 110 days and weighing between 40 kg and 45 kg. Due consideration was given also to the origin of the animals which had come from four different farms as well as to the extent to which deficit situations had developed and to disorders in haematopoiesis.

Age Factors↗