Biomedical subjects
Publications and source records attributed to M Rothe.
Explore the source record for details and available documents.
Dipropylacetate (DPA) was used in the treatment of different types of epilepsy in 112 children aged 1--20 years, with a mean age of 9.2 years, for a period of 19.8 months, ranging from 1 to 49 months. Of this group, 64 children were therapy-resistant to other antiepileptic medications prior to the introduction of DPA; 31 were treated for the first time with an antiepileptic drug, which was DPA; 44 were treated with DPA alone; and 68 had one or more additional antiepileptic medication. The following results were found while DPA was administered in a relatively high dosage with a mean of 48 mg/kg body weight/day and ranging from 7 to 125 mg/kg/day. 1. Statistically, the results are significantly better in primary generalized epilepsy than in partial or in secondary generalized epilepsy. 2. Ninety-two percent of 51 patients who had absences were treated successfully. The same applies to 87% of 30 patients with primary generalized grand mal with spike wave, to all four patients who had impulsive petit mal, and to 47% of the 15 patients who had centrencephalic myoclonic-astatic petit mal. 3. Positive effect of DPA in partial epilepsy and secondary generalized epilepsy was seen only if the EEG pattern was 'centrencephalic' besides focal changes. During therapy with DPA, five patients with pure focal EEG showed an increase in seizure frequency, which demonstrated complete therapeutic failure. 4. Centrencephalic seizure activity (irregular spike wave, 3/s spike wave, and more than 3.5/s spike wave) were treated successfully (P less than 0.001). Focal changes or focal sharp wave with tendency to spread or generalization were treated unsucessfully.
Blood was sampled through indwelling catheters from pigs taken to places for slaughter by various means of transport. Sampling took place at different measuring points between removal from pig pens and actual slaughter. The blood was tested for haemoglobin, haematocrit, glucose, and lactate. The following results were obtained: Removal and transport led to strong Hb and medium Hk rises. The levels, however, returned to normal after one-and-a-half to two hours rest. Stresses caused prior to and during anaestheria led to considerable rise of Hk and Hb as well as to maximum lactate deflection. The latter excitations superimposed all the preceding reactions of the organism. The increased of Hb, Hk, and lactate recorded from animals slaughtered as little as 20 minutes after arrival were higher than those established from animals that had been allowed some rest in between. Transport losses were reduced when the animals were moved in containers due to less motoric stress. However, no mitigation of pork quality setback can be expected as long as strong excitation continues to be caused in the animals before slaughter.
Blood was sampled from fattening pigs fixed with the snout loop in the pen as well as during slaughter after control or container transport. Assays were made of haemoglobin (Hb), haematocrit (Hk), glucose concentration (PG), and lactic acid (MS) in the plasma. The mean values and standard deviations of Hb and Hk were 13.97 +/- 1.14 g/100 ml, 48.36 +/- 3.67 per cent, 15.24 +/- 1.12 g/100 ml, 49.83 +/- 4.04 per cent, 15.32 +/- 1.23 g of 100 ml, and 51.08 +/- 3.73 per cent. The means values of PG were between 51 and 101 mg of 100 ml and those of MS between 8 and 16 mMol/l.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Volatile sulfur compounds from 3 samples of boiled meat (Longissimus dorsi and shoulder meat) have been isolated, separated from the whole flavour complex by mercuric chloride precipitation, regenerated, and examined by gas chromatography. Identification has been carried through by determining Kovats-indices on 4 gas chromatographic columns of different polarity. 29 sulfur compounds have been identified with high certainty, 10 tentitatively. Among 17 thiols, 8 sulfides, 7 disulfides and trisulfides, and 7 heterocyclic compounds only 11 substances have been described previously in literature. The number of mercaptans especially exceeds hitherto knowledge.
Rapidly increasing knowledge about the high complexity of food aromas requires selection or ranking procedures as to the importance of the particular components for flavour impression. For this purpose the concept of aroma values has been discussed which calculates quantitative data in connection with aroma effectiveness of the compounds. The simplification of the concept with respect to the practical application, however, can change the natural system and lead to erroneous conclusions. There are not only interactions between aroma substances of sensoricphysiological character which may not be ignored. Physical conditions like lipid content, distribution of aroma compounds between aqueous and lipid phase or the sorption of volatile substances to the polymer nutrients in foodstuffs are of influence, too.
Classification of 2000 food aroma compounds as to their molecular weight shows an accumulation in the range of 135 to 155, and an upper limit of 310. Molecular masses of substances with high aroma effectiveness are below 200. As aroma compounds are composed only of the elements C, H, O, N and S, even numbers of molecular masses predominate among these substances. A periodicity with an interval of 7 units of molecular mass observed seems to be caused by the presence of complete homologuous series of compounds within the range of low molecular masses.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.