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M Rust

Publications and source records attributed to M Rust.

70 records · Page 4Linked to original sources
PubMed1979

[Long-term follow-up of lung function parameters in patients with idiopathic pulmonary fibrosis treated with prednisone and azathioprin or d-penicillamine (author's transl)].

The prognosis of idiopathic pulmonary fibrosis is poor, it amounts to 4-6 years (after beginning of the symptoms). Spontaneous remissions are very rare, the corticosteroid monotherapy shows a certain success in only 11-16-20% of the cases. Therefore, since 1970 we carry out a combined therapy (see above); the results, confirmed by pulmonary function tets (vital capacity, static compliance, pO2 at rest and after exercise) will be presented. In summary: (1) Azathioprin and Prednisone: After a treatment of 2 years: 6 patients improved, 2 deteriorated, 3 died; the corresponding figures after 4 years were 6/1/4, after 6 years 3/-/5, after 8 years 2/-/3; (2) D-Penicillamine and Prednisone: After 2 years 3/2/4, 1 unchanged; after 4 years 1/-/4, 1 unchanged. The results of the therapy are discussed especially regarding prognosis of the disease and used drugs.

Azathioprine↗
PubMed1979

[Effects of dopamine-droperidol interaction on renal function in rats (author's transl)].

The influence of dopamine and droperidol on the glomerular filtration rate (GFR) and effective renal plasma flow (ERPF) was examined in twelve groups (N = 8) of male wistar rats using the double isotope method with a partially-shielded whole-body counter according to Oberhausen. No alterations of GFR and ERPF could be elicited in normovolaemic rats given dopamine 2--4 micrograns/kg/min (i.v.) alone or in combination with droperidol 0.3 mg/kg. The administration of 10 micrograms/kg/min dopamine alone was followed by a significant (p less than or equal to 0.05) reduction of the ERPF, this effect being abolished by the concomitant use of both drugs. In tourniquet shock dopamine administration or the combined use of dopamine and droperidol produced a significant rise in arterial blood pressure and the renal functions described above. The results in the present study indicate that dopamine infusions will be effective in the presence of froperidol.

Animals↗
PubMed1978

[Ketamine--a suitable agent for emergency situations (author's transl)].

Various surgical procedures have been performed using ketamine alone (Group I) or ketamine-relaxant-air anaesthesia (Group II). In all patients we observed a significant rise in systolic and diastolic blood pressure and pulse rate. The intraoperative values showed a tendency to return to normal. Ten minutes after injection 2 mg/kg body-weight i.v., ketamine caused a significant reduction in arterial PO2 and oxygen saturation as well as a significant rise in arterial PCO2, though these changes were of no clinical importance. In both groups the intraoperative values were normal as compared to the preoperative level. In all cases base excess reflecting the metabolic side of blood gas analysis was within normal range. Based on our findings we recommend the use of ketamine as a sole anesthetic agent for IPPB ventilated as well as spontaneously breathing patients in disaster situations.

Adult↗
PubMed1977

[Influence of ventilatory pattern on the functional situation of the lung during inhalation anaesthesia. Part I: Spontaneous breathing versus IPPB (author's transl)].

After five hours breathing spontaneously enflurane, halothane and methoxyflurane only the rabbits under enflurane showed, apart from a mild respiratory acidosis, no deterioration of pulmonary functional situation. Halothane and methoxyflurane exhibited under the same conditions a significant worsening of elastic behaviour of the lung. The structural bases of the mechanical impairment were atelectasis, dystelectasis and interstitial edema. Postnarcotic examination of lung extracts in the wilhelmy balance showed no abnormalities in the spontaneously breathing animals. If one compares these findings, indicating an irritation of surfactant by halothane and methoxyflurane with the results after IPPB the conclusion can be made that under these circumstances IPPB represents an additional stress for the alveolar lining layer. From the theoretical point of view therefore it would be advisable in patients with surfactant deficiencies to avoid the combination of halothane or methoxyflurane with IPPB. The use of PEEP will be discussed in part II. The value of periodical sighs could not be established under our conditions. Longer periods of spontaneous breathing seem only advisable under halothane but not under enflurane or methoxyflurane because their respiratory depressant properties.

Acidosis, Respiratory↗
PubMed1977

[Irradiation therapy of vertebral angionomas: results in 62 patients during the years 1939 to 1975 (author's transl)].

62 cases with vertebral hemangiomas and clinical symptoms from 1939-1975, treated by radiotherapy are reported. In about 60%, radiotherapy resulted in permanent significant improvement or freedom of angioma related symptoms. In 7 cases with symptoms of severe compression of the myelon, decompressive laminectomy was performed, followed by radiotherapy. The radiation dose in the vertebrae were: 3000-5000 rd, 100-200 rd single dose, 5 times per week. Hemangiomas of the vertebrae are an accepted indication for irradiation. We recommend doses about 4000 rd, 150-200 rd single dose, 5 times per week. In cases with severe cord compression decompressive surgery is to be performed first.

Female↗
PubMedDate not supplied

Epidemiology, diagnosis, and management of Alzheimer's disease and related disorders: implications for minority populations.

The experience of Alzheimer's disease (AD) and related dementias in minority populations must be understood in the epidemiological, diagnostic, treatment, and care contexts which surround it. This article describes those contexts, and offers an analysis of how efforts to improve the management of dementia among minorities are likely to be affected by them. An overview of the etiology, diagnosis, and treatment of AD and related disorders is presented; current and proposed health care services are described; and planning and policy considerations which result from the nature, epidemiology and care demands of dementia are reviewed. We conclude with a series of recommendations for the enhancement of our healthcare system to meet the needs of minorities with dementia.

Alzheimer Disease↗