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Biomedical subjects

M S Neff

Publications and source records attributed to M S Neff.

11 recordsLinked to original sources
PubMed1987

Intestinal mucormycosis in hemodialysis patients following deferoxamine.

Two maintenance hemodialysis patients receiving deferoxamine to chelate iron and aluminum developed intestinal mucormycosis. One patient had pulmonary mucormycosis as well. The patients lacked the usual predisposing factors to mucormycosis, ie, diabetes and acidosis, but both had liver disease. The role of siderophores such as deferoxamine in promoting certain infections is discussed with reference to this particular clinical setting.

Deferoxamine↗
PubMed1987

The role of thrombolysis in hemodialysis access occlusion.

Thirty-eight occluded hemodialysis accesses were infused with urokinase on 43 occasions. In 49% of the cases, the access patency was reestablished for a week or longer, although 38% of this subset subsequently rethrombosed. Postthrombolysis angiography detected a stenotic segment in 14 of 22 angiograms (64%). Local bleeding was common, but the thrombolytic therapy was generally well tolerated. Percutaneous thrombolysis in conjunction with angiography and access revision provides a clinically useful means of access preservation.

Female↗
PubMed1986

Progressive systemic sclerosis with the nephrotic syndrome and acquired factor X deficiency.

A patient with progressive systemic sclerosis (PSS) involving skin, digit, esophagus, and lung developed the nephrotic syndrome and rapidly progressive renal insufficiency. Renal pathology revealed capillary collapse, cellular crescents, arteriolar hyaline deposition, and mesangial proliferation. On immunofluorescence IgM, C3, and fibrinogen were present in mesangium and capillary walls. Prebiopsy coagulation screening revealed a factor X deficiency which caused substantial prolongation of the partial thromboplastin time without an overt bleeding diathesis. The acquired factor X deficiency resolved after fresh frozen plasma and vitamin K administration, although some spontaneous improvement was noted. Nephrotic syndrome may occasionally be seen in the acute fulminant form of PSS and should not deter diagnosis of PSS.

Capillaries↗
PubMed1979

A wearable artificial glomerulus.

We have shown that hemofiltration can be conducted for 16 hrs/day for more than 3 continuous days by connecting an Amicon 0.2 M2 hemofilter to an arteriovenous shunt. We can produce over 8 ml/min of ultrafiltrate with no external pump, and this ultrafiltrate can be replaced by having the patient drink an electrolyte-glucose solution. Anticoagulation can be attained with heparin, warfarin and cyproheptadine. Each filter can be expected to function at least 48 hrs before it must be replaced.

Filtration↗
PubMed1978

Bilateral nephrectomy for hypertension in patients with chronic renal failure on a dialysis program.

During the last 6 years 33 bilateral nephrectomies have been performed for severe hypertension in patients with chronic renal failure on a dialysis program. Nephrectomy resulted in a prompt and sustained reduction in blood pressure, an improved sense of well-being and a gain of weight. Despite the fact that the mean hematocrit decreased from 25 to 18 per cent all patients thrived. The nephrectomy group showed an 85 per cent 5-year cumulative survival rate compared to 55 per cent in the non-nephrectomy group. There was 1 mortality and low morbidity. Simultaneous nephrectomy by 2 teams, using a posterior approach, proved more satisfactory than an anterior or bilateral flank apprach. The indications for and arguments against bilateral nephrectomy are discussed.

Adult↗
PubMed1975

Uremic pleural effusion. A study in 14 patients on chronic dialysis.

During a 21/2-year period, studies were done on 14 patients with chronic renal failure to evaluate pleural effusions which we believe were secondary to the uremic process. The patients with uremic pleural effusions closely resembled those in the group with chronic renal failure as a whole with respect to diagnosis and clinical features. Fever and pericarditis were noted in half the patients. The pleural fluid appeared serosanguineous or hemorrhagic in 10 of 14 patients and contained a predominance of lymphocytes more often than of neutrophils. Elevated protein and lactic dehydrogenase (LDH) levels gave the effusion characteristics of an exudate. Pleural tissue obtained by pleural biopsy or autopsy showed chronic fibrinous pleuritis in every patient. With continued dialysis the effusions resolved in 4 to 6 weeks after thoracentesis in 11 patients and recurred in 3 patients.

Adult↗