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Biomedical subjects

M Sabău

Publications and source records attributed to M Sabău.

At least 55 records · Page 3Linked to original sources
PubMedDate not supplied

Effect of age on the heart electrical phenomena, left ventricular wall thickness and blood pressure in men.

The effect of age on the maximal spatial QRS vector (MSQRSV) in the Frank lead system was correlated with th posterior left ventricular wall thickness (PLVWT), the interventricular septum thickness (IVST) determined by echocardiography, and with blood pressure in 300 normal men, distributed by age groups (20-29, 30-39, 40-60). With advancing age, a significant decrease of MSQRSV accompanied by a significant increase of PLVWT was observed while the increase of IVST and of blood pressures with age were found non significant. It was concluded that: 1. blood pressure is not the sole determinant of hypertrophy; 2. myocardial hypertrophy is not the sole determinant of cardiac voltage increase; 3. there is some degree of myocardial sclerosis in healthy people aged over 40-60 years; 4. in left ventricular hypertrophy the left ventricular muscular mass cannot be accurately predicted from the heart electrical phenomena; 5. the results obtained were in agreement with those of authors describing different aspects of normal Frank ECG and vectorcardiogram (VCG) in subjects under and over 40-50 years of age; 6. the variability of the degree of age influence on normal ECG from one country to another could explain the different diagnostic criteria for the same cardiac disease in computerized programs.

Adult↗
PubMedDate not supplied

Absence of increased cardiac voltage and the importance of Q vectors for the diagnosis of left ventricular hypertrophy in early stages of hypertension in patients over 40 years of age.

The quantitative VCG criteria (VCGer) for left ventricular hypertrophy (LVH) and their diagnostic power were determined in 165 hypertensive men and 86 women over 40 years of age without congestive cardiac failure in comparison with 91 normal men and 108 normal women. The patients were grouped according to the presence or absence of LVH determined by X-ray (men: 96 without and 69 with LVH, women: 41 without and 45 with LVH). The proper statistical methods were used taking into account whether their distributions were symmetrical or asymmetrical. We found some sex differences of VCG criteria. The most striking results were the lack of increased voltage, and the great sensitivity of the orientation of Q vectors to the left (Q left). Q left may be induced by: 1. a septal hypertrophy, alone or accompanied by a hypertrophy of the anterior and posterior paraseptal regions of LV wall, 2. by a subendocardial ischemia at these levels induced by the increase of intraventricular pressure, 3. by possible spatial change of the septum, 4. by all these factors acting synchronously, 5. by other, unknown factors. These VCGcr for LVH found by us are different from those in the literature, but they are valid in Romania.

Adult↗
PubMedDate not supplied

Studies concerning the role of myocardial hypertrophy and of intramural tension as determinants of the increased voltage in concentric left ventricular hypertrophy.

In order to study the role of myocardial hypertrophy and of the intramural tension as determinants of the increased voltage in concentric left ventricular hypertrophy, the amplitude of intracellular action potentials in frog and rat myocardium and of monophasic action potentials recorded in dogs by suction electrodes were studied. Increased amplitudes of intracellular action potentials were seen neither in experimental LVH in rats nor during stretch in frog and rat myocardium. The increased intramural tension in dog heart during norepinephrine perfusion or in heart-lung preparation during increased peripheral resistance does not increase the amplitude of monophasic action potentials. The abrupt hypertension induced by norepinephrine is an inadequate model for the study of the effect of increased intramural tension. The increase of the voltage in LVH cannot be accounted for by the increase of action potentials of each hypertrophied fibre. Many factors cooperate in producing increased voltage of LV in LVH.

Animals↗
PubMedDate not supplied

Serologic markers of hepatitis B and A infections in the healthy population.

The prevalence of the serologic markers of hepatitis B virus (HBV) and of antibodies to hepatitis A virus (HAV) were determined by radioimmunoassay in 200 healthy subjects. One hundred and seven persons (53.5%) were positive for at least one marker of HBV. The prevalence of each marker was: HBsAg - 9.0%, anti-HBs alone - 2.0%, anti-HBc alone - 2.5%, anti-HBs and anti-HBc - 29.0%, HBsAg and anti-HBc - 11.0%. Evidence of a previous infection with HAV was found in 155 persons (77.5%); three of them had anti-HAV type IgM. These findings indicate that in the area investigated HAV infection is endemic, and HBV infection has a trend towards endemicity.

Adolescent↗
PubMedDate not supplied

Hepatitis B antibodies in hospital personnel.

Sera from 544 hospital personnel members with different degrees of exposure to the agent of hepatitis B were tested for HB8Ag and anti-HB8 by counterelectrophoresis, radioimmunoassay and passive hemagglutination. The laboratory staff and persons having direct contact with patients exhibited a significantly higher prevalence of anti-HB8 (16.2%) as compared with the other groups: administrative staff (4.4%), healthy persons (4.6%) and blood donors (7.9%). These data prove the relationship between exposure to HB8Ag and anti-HB8 prevalence, more obvious in the laboratory staff handling human serum and plasma specimens (anti-HB8 incidence--25%).

Antibodies↗