[Personal experience with the use of Lorcainide in the treatment of Wolff-Parkinson-White syndrome in infants and older children].
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Biomedical subjects
Publications and source records attributed to M Samánek.
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In 24 patients with cystic fibrosis (6-20 years old), divided into two groups, we studied indices of airways obstruction before, 20-30 min and 2 h after chest physiotherapy. The physiotherapy lasted for 30 min and included expectoration of 2-10 ml of sputum. In one group of 14 patients, studies were made only 30 min after chest physiotherapy. No significant improvements of the ventilatory tests occurred. In fact, Vmax at 25% of VC deteriorated (P less than 0.05) in this group as a whole. In some patients also CV/VC increased, and N2 and CO2 alveolar slopes became steeper. Only Gaw/TGV improved in 20% of the patients by more than 10% of the control value. In the second group of 10 patients, ventilatory studies were repeated 3 times at one month intervals. They did not change significantly at 20 min and 2 h after chest physiotherapy. Gaw/TGV value improved by more than 10% in 20% of the patients. During chest physiotherapy, the patients were stimulated to cough. This might contribute to the immediate negative effects on ventilatory function by causing collapse of the central airways, as documented by cinebronchographic studies in 8 patients.
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The authors document the importance of echocardiograhy (ECHO) with special respect to the pulsed Doppler technique (PDE) in the diagnosis of congenital heart diseases. Typical ECHO and PDE findings in atrial and ventricular septal defects, patent ductus arteriosus, valvular stenosis and insufficiency, absence of pulmonary valves, tricuspid and pulmonary atresia, Fallot's tetralogy, arterial trunk, double-outlet right ventricle, transposition of the great arteries, total anomalous pulmonary venous drainage and hypoplastic left-heart syndrome are described. The authors conclude that a combination of M-mode, cross-sectional and pulsed Doppler echocardiography permits a comparatively detailed non-invasive diagnosis of the entire spectrum of congenital heart diseases.
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75 patients who had been operated between the ages of 3 and 17 years for juxta- or postductal coarctation of the aorta were investigated 11.2 years (1-19) later, when they had reached the mean age of 22 years. In 10 patients (13%) there had been an associated cardiac defect. Of the 65 patients without cardiac complications, 10% showed normal physiological values and 64% showed satisfactory results of surgery. There was moderate hypertension in 18% of the patients and in 6 (10%) there was a pressure gradient between the upper and lower extremities greater than 15 mm Hg. Aortography revealed recoarctation in only 3 cases (5%). The electrocardiogram was abnormal in 48% of the patients. Chest films showed the presence of specific and nonspecific signs of coarctation in 89% of the cases. Hemodynamic investigation by radiocirculography showed normal values in most instances.
Three patients with total anomalous pulmonary venous drainage (TAPVD) into the innominate vein were studied by using M-mode and pulsed Doppler echocardiography. An abnormal continuous flow towards the transducer in a suprasternal notch position detected by pulsed Doppler echocardiography in the left hemithorax leftward of the aortic echo is a sign of blood flow through the left vertical vein into the innominate vein. This finding is highly specific for TAPVD. High-velocity flow across the tricuspid valve, disturbed flow in the right pulmonary artery and abnormal flow in the left atrium are additional important pulsed Doppler echocardiographic findings in TAPVD. Right ventricular enlargement and paradoxical interventricular septal motion by M-mode echocardiography were not specific enough to distinguish TAPVD from other right ventricular volume overload lesions. An echo-free space posterior to the left atrium was not recorded.
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