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Biomedical subjects

M Schultz

Publications and source records attributed to M Schultz.

At least 145 records · Page 8Linked to original sources

[Acute and chronic middle ear pathology in mediaeval man (author's transl)].

The variety, extent and consequences of middle ear cleft disease in ancient times is reviewed. The findings of macroscopic radiological and scanning electron microscopic examination of skeletal material from two south German Merovingian populations and two pre-Columbian population groups from the south west of North America are presented. The possibility of false diagnosis was considered. Cases previously described are reviewed, summarized and compared. In both the Frankish-Alemannian populations diseases of the middle ear cleft significantly occur more frequently within the lower social groups. From this it is possible to deduce that external factors were paramount in the pathogenesis of these diseases in early cultures, whereas in the present mid-European populations constitutional factors predominate. In contrast to recent claims (Cockburn, 1977) that diseases of the middle ear were rare amongst inhabitants of the Americas before the arrival of Europeans, earlier literature and the observations presented in this article show that these diseases were not so uncommon. Cases found in ancient Peru show no evidence of surgical treatment, although the standards of surgery, which at that time included trephination, could have made this feasible.

Adolescent↗

The effect of three days of blood glucose normalization by means of an "artificial endocrine pancreas" on the concentrations of growth hormone, glucagon, and cortisol in juvenile diabetics.

Glucagon, growth hormone, and cortisol secretion was studied in seven male insulin-dependent diabetics under conventional subcutaneous insulin therapy and after three days of blood glucose normalization attained by the artificial endocrine pancreas (Biostator-GCIIS). The diurnal hormonal profiles under the two types of therapy were compared. Six healthy male students served as control group. A three-day period of blood glucose normalization in insulin-dependent diabetic can restore glucagon secretion to normal. Growth hormone secretion is decreased but not completely normalised. Cortisol secretion is slightly decreased. It is concluded that prolonged normoglycemia achieved by means of an artificial endocrine pancreas may completely control endocrine abnormalities in insulin-dependent diabetics.

Adult↗

[An osseus tumor in the skull of a precolumbian indian from Peru (author's transl)].

A walnut-sized, stalked, osseus tumor in the region of the protuberantia occipitalis externa of the skull of a precolumbian indian from Peru is described. Radiological and histological examinations grouped this neoplasm with the fibro-osseus tumors. Cytologically, it is one of the rarely seen nearly compact forms of the large, mostly spongy osteomas of the skull roof.

Diagnosis, Differential↗

[Malformations of odontogenic tissue in prehistoric human bone material. A contribution to the differential diagnosis of odontomas].

Three cases of hard tissue formations of odontogenic origin are presented. The objects were discovered among skeletal finds in prehistoric settlements. The morphology of these objects is described with macroscopical, histological, and radiological methods. All three cases are odontomas. The differential-diagnostic possibilities of these formations, their development and the frequency of their occurrence are discussed. Odontomas are not interpreted as tumors, but rather as malformations and are contrasted to blastomas of odontogenic tissues (e.g. ameloblastoma).

Adult↗

[New studies and considerations on the pathology of the primate skull. A contribution to the "Gundu" problem].

The problem of 'Gundu' in primates is discussed. Cases of so-called 'Gundu' in the literature, two cases in Gorilla and one in Lagothrix, are dealt with. Histological and X-ray techniques are used. One case (Lagothrix) represents the so-called simian bone disease, which is metabolic disorder and is due to a secondary nutritional hyperparathyroidism. The other two cases (Gorilla) show symmetrical bony tumors of the maxilla. The origin is uncertain. Gundu, Paget's disease and primary hyperparathyroidism Recklinghausen have not been observed in primates so far.

Animals↗

[Isolation and characterization of 11-S-globulins from sunflower seeds (Helianthus annuus L.)].

The isolation of II-S globulin, which is homogenous on sedimentation and gel chromatography (s020, w = II,8 S), from sunflower seeds is achieved by cryoprecipitation from solutions of high ion strength (I approximately 0.5 to 1.8) with simultaneous reduction of the salt concentration (I approximately 0.3) and repeated gel chromatography on Sephadex G-200. By this technique, the 7-S component which occurs in small quantity is isolated too. In solutions of low ion strength (I less than 0,3), the II-S globulin dissociates to give a 7-S component. At high or low pH values (greater than 9.0 and less than 3.0, respectively), the latter dissociates to give a 3-S component, and in the presence of urea it further dissociates to give subunits. In the presence of sodium of sodium chloride, the dissociation of the 3-S component may be inhibited. The various steps of dissociation can be studied by means of ultracentrifugal sedimentation, gel chromatography and gel electrophoresis.

Globulins↗

Phospholipid biosynthesis: the activity of phosphatidic acid phosphohydrolase in the developing lung and amnionic fluid.

The presented data suggest that PAPase may, indeed, be important in the biosynthesis of lung phospholipids. The observed increase in the specific activity of rabbit lung precedes the "surge" of phosphatidylcholine concentration and surfactant biosynthesis by at least 24 hours. In human amnionic fluid, PAPase specific activity was markedly increased in pregnancies of 35 weeks of gestation or more. The increase in the specific activity of PAPase preceded the "surge" of acetone precipitated phosphatidylcholine. The reported studies may provide an additional procedure to examine the problems associated with surfactant biosynthesis.

Amniotic Fluid↗