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Biomedical subjects

M Sherriff

Publications and source records attributed to M Sherriff.

At least 91 records · Page 5Linked to original sources

Accuracy of fit of cobalt-chromium removable partial denture frameworks on master casts.

Fifty-six cobalt-chromium removable partial denture frameworks made to the same design were found to fit their master casts poorly. Spaces were significantly greater between palatal aspects of abutment teeth and palatal reciprocal arms, and between buccal aspects of occlusal rests and rest seats. Excessive contraction towards the centre of the palate was found. Expansion of the refractory investment may not have compensated adequately for solidification and cooling contraction of the cobalt-chromium alloy. Although dimensional changes in investment and casting are by volume, no evidence of anisotropic expansion of castings in a vertical direction was found.

Chromium Alloys↗

The effect of reducing the number of clasps on removable partial denture retention.

Retention to a master model of 10 nominally identical chrome-cobalt removable partial denture castings with standardized bilateral molar and premolar clasps engaging 0.25 mm (0.01 inch) undercuts and 10 castings with clasps engaging 0.5 mm (0.02 inch) undercuts was measured on an Instron testing machine. The retention of each framework was remeasured as the clasps were removed in one of two sequences. Differences between frameworks, number of clasps, and depth of undercuts were all significant. The order of removal of the clasps was not statistically significant. In a separate experiment the position of the dislodging force was found to be significant. It was concluded that the dislodging force was dependent on (1) the fit of the framework, (2) the depth of the undercut, (3) the number of clasps, and (4) its point of application.

Bicuspid↗

Effect of bracket and wire composition on frictional forces.

Previous work on friction has considered movement of single teeth along an archwire. The aim of this investigation was to consider friction in buccal segment attachments during overjet reduction involving sliding mechanics. A buccal segment model was constructed to compare friction in steel and ceramic brackets, using steel and nickel titanium wires of two sizes along with a new experimental polymeric wire. The results indicate that friction during overjet reduction is minimized by using larger dimension rectangular wires and by using steel rather than nickel titanium. Comparing steel with ceramic brackets in series, the latter show greater frictional resistance, but only when used with the smaller rectangular wires. The combined effect of environment, ligation, bracket, and archwire significantly reduced the difference. Clinically, there may, therefore, be little to choose between steel and ceramic brackets in the buccal segments, with wire choice as determined by tooth displacement being more important. Comparison of the results with those obtained using single brackets illustrates the problems of interpreting results from friction experiments. The polymeric archwire in its present form was found to be unsuitable for use in orthodontics.

Acetals↗

The fate and survival of amalgam and preformed crown molar restorations placed in a specialist paediatric dental practice.

The fate of 1688 amalgam restorations and 716 preformed crowns placed in permanent and primary molars in a specialist paediatric dental practice over a 10-year period by one operator is reported. For primary molar amalgams, the replacement rate, true failure rate and 5-year survival estimates were, for Class 1 restorations, 16.1%, 3.9%, 73.3%, respectively, with an estimated median survival time greater than 8.5 years, and for Class 2 cavities 14.7%, 11.6%, 66.6%, with an estimated median survival time greater than 7.5 years. For permanent molar amalgams, the replacement rate, true failure rate and 5-year survival estimates were for Class 1 restorations 11.5%, 6.5%, 76.8%, respectively, with an estimated median survival time greater than 9.3 years, and for Class 2 restorations 9.8%, 8.0%, 82.2%, with a median survival time greater than 8.5 years. For all preformed crowns, the replacement rate, true failure rate and 5-year survival estimates were 2.8%, 1.9%, 92.0%, and the estimated median survival time greater than 7.64 years. No relationship was observed between the age of the patient and the age of replaced restorations. No significant difference was found between the survival rates of Class 1 and 2 amalgam restorations in primary or permanent molars, nor between first and second primary molars.

Adolescent↗

A study model analysis of adult unoperated Sri Lankans with unilateral cleft lip and palate.

The maxillary arch-form of 41 Sri Lankan adults with unoperated complete unilateral cleft lip and palate (8 female and 33 male) were compared to a control group of 100 normal Sri Lankan adults (45 female and 55 male). The teeth in the cleft group were smaller than their equivalents in the control group, the most marked difference being found in the central and lateral incisors. Arch widths of the cleft groups were reduced, more anteriorly than posteriorly, resulting in more V-shaped arches. No differences were found in the arch length or chord lengths between the groups. Crossbites occurred in 19.5 percent of the cleft group as compared to none of the controls. The overjet was greater in the cleft group than in the controls. A higher percentage of missing teeth was recorded in the cleft group.

Adolescent↗

Expression of epidermal growth factor receptor on oral squamous cell carcinoma.

The expression of the receptor for epidermal growth factor (EGF) in normal oral mucosa, papillomas and squamous cell carcinoma (SCC) has been determined by immunohistology and autophophorylation studies. Immunoreactive receptor was localised using two antibodies which recognise the receptor; EGFR1 which reacts with sequences in the external domain of the receptor and F4 which recognises sequences in the internal domain. EGFR was present on basal, suprabasal and some spinous cells of normal oral mucosa. Regional variation in the distribution of receptor was apparent. A similar pattern of receptor expression was seen on oral papillomas. The distribution and intensity of epidermal growth factor receptor (EGFR) expression varied between 20 patients with oral SCC. The staining patterns seen with the two antibodies were similar on all tissue types. The protein tyrosine-kinase activity of the receptor present on eight oral SCC was also examined by immunoprecipitation and autophosphorylation studies. This procedure also demonstrated variations in the amount of functional EGFR in these tumours. There was no significant correlation between the level of EGFR expression and tumour behaviour.

Carcinoma, Squamous Cell↗