A 5-year-old girl with a very rare autosomal recessive disease, Hurler's syndrome, is described. This is a progressive disease and the main symptoms, typical for metabolic disorders of mucopolysaccharides were present. Only intransprarent cornea was not manifest, as it usually appears in advanced age. Dental examination confirmed the following symptoms: hypertrophic alveolar process; spaced, carious teeth; long tongue; enamel hypoplasia; hypocalcification; open teeth occlusion, etc. The prognosis is characterized by aggravation of symptoms till death in the second decade of life. The therapy is symptomatic.

Child, Preschool↗

PubMedDate not supplied

[Morpho-etiologic problems of pseudomembranous lesions of the colon].

Pseudomembranous colitis (PMC) is an infectious colon disease caused by Cl. difficile toxin. Each change of the intraluminal microbiological balance as well as damages of the hemato-enteral barrier may cause changes in the enteral flora and selective proliferation of anaerobic bacterial strains. PMC has been most frequently described after enteral application of antibiotics, even of those with the broadest use. In nonocclusive mesenterial ischemia changes similar to postantibiotic PMC may occur but pseudomembranous changes are confluent and associated with haemorrhagia and microthromboses. Some systemic and chronic inflammatory diseases of the colon may be a basis for development of anaerobic Cl. difficile which one should have in mind at establishing endoscopic and bioptic diagnosis.

Adult↗