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Biomedical subjects

M Singh

Publications and source records attributed to M Singh.

At least 1,081 records · Page 60Linked to original sources
PubMed1982

Pyogenic liver abscesses in children.

Five children with pyogenic liver abscess were admitted to Institute of Child Health, Kabul during the period 1978 to 1980. All patients were males, and their ages ranged from 4 to 10 years. The clinical picture was characterized by fever, upper abdominal pain, enlarged tender liver with raised right dome of the diaphragm. The abscesses were located in the right lobe of liver in all cases, and they were solitary in three cases. Staphylococcus aureus was the etiologic agent in four cases and Escherichia coli in one. Open surgical drainage coupled with prompt parenteral antibiotic therapy in all cases seem to have favorably influenced the outcome. With a high index of suspicion pyogenic liver abscess in children can be diagnosed clinically without the aid of hepatic radionuclide scanning.

Child↗
PubMed1982

Erythrocytes sedimentation profiles under gravitational field as determined by He-Ne laser. II. Influence of erythrocyte shape.

The erythrocyte sedimentation profiles under gravitational field, by scanning the sample holder along the height and width, containing the blood samples with normal and crenated erythrocytes, are determined. The normal shape of erythrocytes has been altered by the controlled He-Ne laser exposures and this change, as observed microscopically, is similar to that as produced by other methods. At low exposure the erythrocytes have normal appearance, whereas, at 400 mJ/cm2, the percentage of crenated cells is 25 +/- 5 percent. It is observed that the modification of the shape influences the sedimentation characteristics of the erythrocytes. The erythrocytes tend to move faster after being exposed to lower exposure and slower after being exposed to higher exposure compared to that of normal erythrocytes. The possible mechanism associated with this change is discussed.

Blood Sedimentation↗
PubMed1982

Hemorheological characteristics of blood in various disease: diabetes mellitus, hypertension, acute infection, ischaemic heart disease & attempted suicide.

The hemorheological characteristics of the blood samples, obtained by venepuncture from various groups of patients, are determined. Shear stress-shear rate relationship were determined by capillary viscometer at various shear rates ranging from 1 sec-1 to 30 sec-1. Erythrocyte sedimentation rate (ESR) was determined by Westergren method. The results indicate that at constant hematocrit, the slope of the line representing shear stress-shear rate relationship, and ESR of blood samples change, depending on the clinical conditions of the individuals. For various values of the hematocrits, the variation of the above mentioned parameters along with fibrinogen level & blood viscosity, in various diseases are given.

Blood Circulation↗
PubMed1982

Pancreatic acinar cell function and morphology in rats chronically fed an ethanol diet.

The aim of the present study was to determine the effect of prolonged ethanol intake on the morphology and protein metabolism in the rat pancreatic acinar cells. Weight-matched triplets of Sprague-Dawley rats were fed Lieber-DeCarli diet containing 5% (wt/vol) concentration of ethanol, isocaloric amounts of Lieber-DeCarli diet, or rat chow ad libitum for 6, 12, and 18 mo. In the ethanol-fed group, histologic studies by light microscopy showed absence of protein plugs in the pancreatic ducts and/or pancreatitis, but electron-microscopic evaluation revealed progressive accumulation of lipid droplets in acinar and ductal cells. No definite changes in the mitochondria and endoplasmic reticulum were noticed. Biochemical studies revealed increased specific activity of trypsinogen, chymotrypsinogen, and lipase, and decreased specific activity of amylase. Trypsin-inhibiting capacity was decreased in the tissue and in the medium in a progressive fashion. There was no increase in the secretion of total protein. These data show a complex and a nonparallel alteration of specific digestive enzymes and trypsin inhibitor in this model of chronic ethanol intoxication that may be of relevance to occurrence of pancreatitis.

Alcoholism↗
PubMed1982

A study on the prevalence of antibodies to Toxoplasma gondii in Singapore.

The indirect fluorescence antibody technique has been employed to study the prevalence of toxoplasma antibodies in Singapore. 42.5% of clinically suspected cases of toxoplasmosis showed antibody titres. Of these, 17.5% had titres greater than or equal to 1.64. Malays and Indians have higher positive rates compared to the main ethnic group, the Chinese. Antibody titres are found in both males and females and span through the various age groups. The possible mode of transmission is discussed and the importance of congenital toxoplasmosis is indicated.

Adolescent↗
PubMed1982

The nephrotic syndrome associated with filariasis.

A patient with lymphatic filariasis, developing the nephrotic syndrome is reported. Renal biopsy showed a diffuse mesangial proliferative glomerulonephritis with C3 deposition in the glomeruli. Glomerulonephritis associated with filariasis has been reported previously, however definite identification of filarial antigen in glomerular deposits or of specific antibodies in kidney eluates is still awaiting.

Adult↗