[On the cerebral effectiveness of oral Tropodil therapy].
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Biomedical subjects
Publications and source records attributed to M Steinbach.
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Under the influence of a primary prevention trial of coronary heart disease carried out for 10 years (1971-1982) in male subjects aged 40 to 60 years at entry, the curves of the seasonal variation of the incidence of myocardial infarction, sudden death and stroke were changed. The most important reductions of the incidence of these events were registered in spring and in September. In the rest of the year the effect of the action becomes variable according to the month and to the particular major events. These observations are discussed as related to their possible cause and to the necessity of a change of action methodology according to the period of investigation.
A group of 4800 men, aged fourty to sixty at entry, subjected to a multifactorial prevention trial of coronary heart disease for a ten-year period, showed spontaneous seasonal variations of serum cholesterol, characterized by increases in winter and decreases in summer. The authors discuss the relationship between the food changes and the seasonal variation of serum cholesterol values.
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By means of the factor analysis and the discriminant analysis we studied the structure of the interrelations between the risk factor variables in cardiovascular diseases. The reduction of the dimensionality of data by extracting a small number of common factors has allowed us the identification of the three main factors whose structural change reflects the successive passage through the states of health, risk and illness. To estimate the effectiveness of the prevention action we calculated the D2 distance between the groups of subjects at the two extreme moments. In the last part of the study we determined the predictive value of the risk factor variables considering in turn the main risk factors as criterion variables in terms of the other risk factors taken as predictors.