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Biomedical subjects

M Steinbach

Publications and source records attributed to M Steinbach.

63 records · Page 4Linked to original sources
PubMedDate not supplied

Use of discriminant analysis in the calculation of a prognostic index for the primary prevention of cardiovascular diseases.

Methods of multidimensional mathematical statistics were used for the combination of a set of simultaneous characteristics (risk factors) related to the development of ischemic heart disease into a single representative value as an index of the individual state. Successive values of this index give the time dependent changes of the individual state of health. Considering that these changes in time can be modelled linearly a classification criterion can be obtained taking also into account the evolution of the individual state of health.

Coronary Disease↗
PubMedDate not supplied

The Bucharest Multifactorial Prevention Trial of Coronary Heart Disease--ten year follow-up: 1971-1982.

The trial begun in 1971 and the paper brings the results after a ten-year follow-up. Both the intervention and control group contained 5000 men with a similar socioeconomic and professional structure; the intervention group was examined every six months in the first 5 years and annually in the second phase. The control group was examined "only after" 5 years and a second time at the final moment. The decreases of the cumulative ten-year incidences were: for hard events--26.7%; for myocardial infarction--20%; for fatal myocardial infarction--52%; for stroke--31%; for cardiovascular mortality--38%; for total mortality--14%. The trend of serum cholesterol and cigarettes/day was downward, but the blood pressure had a rather flat evolution in the intervention group. The control group disclosed also some downward trends.

Adult↗
PubMedDate not supplied

The methodology of cardiovascular disease epidemiology.

Chronic disease epidemiology emerged from a methodological necessity, namely to break the deadlock of the medical science faced with a sudden upsurge of these diseases, especially cardiovascular, after the Second World War. The author analyses the shortcomings of clinical investigation in contrast with the epidemiological approach, the qualitative and quantitative prerequisites of the latter, as well as its methodological instruments, pointing out misunderstandings and improper uses of some terms i.e., epidemiology is not one and the same thing as ecology; epidemiology precludes passive detection; the environmental agent is not identical to the risk factor; the risk factor is not diagnostic. It is worth making these distinctions in order to enhance the value of epidemiology as a first step toward prevention.

Cardiovascular Diseases↗
PubMedDate not supplied

The Bucharest multifactorial prevention trial of coronary heart disease. General methodology and risk factor correction after five year follow-up (1971-1977).

Both the intervention and the control group included each 5000 men aged 40-60 years, randomly selected by their home address in five districts of the city of Bucharest. The intervention group underwent an "at entry" examination for risk factor detection (high serum cholesterol, high blood pressure, overweight, diabetes, minor ECG abnormalities, family history) and subsequently a five-year multifactorial intervention aimed to reduce the risk factors. Both groups were followed up in this lapse of time for major end-points: myocardial infarction, stroke, sudden death. The qualitative analysis of the results used ten evolution indices based on a quantal counting and lead to a classification of risk factors which allowed the setting up of a strategy for their correction. The quantitative analysis showed the following decreases between the first and the last examination in the intervention group: for serum cholesterol greater than or equal to 250 mg/dl -17%; for cigarettes/day greater than or equal to 15-53%; for overweight greater than or equal to 30% - 13.57%; for high blood pressure -8%; for the overall risk computed by multiple regression -33.8%.

Adult↗
PubMedDate not supplied

Two multidimensional methods applied to the study of cardiovascular risk factor.

In the epidemiologic study of chronic diseases, especially that of cancer and heart disease, it is often necessary to resort not only to the work of epidemiologists but also to that of mathematicians and statisticians. The present study is an application of two main methods of multivariate analysis -- factorial analysis and canonical correlation analysis -- to the determination of the evolution of the risk to develop coronary heart disease in an urban population.

Coronary Disease↗
PubMedDate not supplied

The Bucharest multifactorial prevention trial. The changes of morbidity and of general and specific mortality.

The paper presents the results of the Bucharest multifactorial prevention trial of coronary heart disease, concerning changes in cardiovascular morbidity and mortality during the first 5-year-period of follow-up. The age adjusted 5-year-rates disclose important reductions in the intervention group in comparison with the control one: for hard events (myocardial infarction, stroke, acute coronary insufficiency)--by 41%; for myocardial infarction--by 35%; for coronary mortality--by 38%; for stroke--by 39%; for cardiovascular mortality--by 30%. The decrease of hard events, myocardial infarction and stroke incidences are statistical significant. The evolution curves of cardiovascular morbidity and mortality show that both groups (the intervention as well as the control one) began with near the same values, but on the way and especially after 5 years they are differently located, those of the control group being higher than those of the intervention group.

Adult↗
PubMedDate not supplied

A Romanian contribution to the epidemiology and prevention of cardiovascular diseases.

The paper presents the scientific activity developed in the last thirty-five years by a team of cardiologists, internists, biologists, biochemists, biomathematicians and computer specialists in the "N. Gh. Lupu" Institute of Internal Medicine (Bucharest) in the field of epidemiology and prevention of cardiovascular diseases. The main places of the epidemiological surveys were the Danube Delta (among fishermen) and the Gurghiu Valley (in the Eastern Carpathians) among lumberjacks, two collectivities selected by the nature of their diet in order to prove the role of fat saturation in the pathogenesis of atherosclerosis. In 1971 this team began one of the long-lasting projects of primary prevention of coronary heart disease (on 10,000 middle-aged men) which is now at its 25-year follow-up ("The Bucharest Multifactorial Prevention Trial of Coronary Heart Disease"). The analysis of this activity refers to more than hundred works of the team.

Cardiovascular Diseases↗
PubMedDate not supplied

Coronary heart disease and its risk factors in a group of 5,000 middle aged men in urban environment.

The results obtained at entry in the subjects included in a pilot study (Institute of Internal Medicine, Bucharest) for the detection and prevention of coronary heart disease and hypertension, are presented. These data are the prevalences of the risk factors of coronary heart disease (high serum cholesterol, hypertension, smoking, overweight, diabetes, nonspecific minor ECG signs, family history), as well as the prevalences of the various forms of coronary heart disease. The study of the frequency distribution of biologic parameters likely to become risk factors showed that in middle aged subjects the upper limit of the normal should be lowered from the 95th percentile to the 76th one.

Age Factors↗