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Biomedical subjects

M Steinling

Publications and source records attributed to M Steinling.

At least 73 records · Page 4Linked to original sources
PubMed1987

[Regional cerebral blood flow and its reactivity to acetazolamide in transient ischemic attacks. Study of 20 cases by gamma emission tomography].

We have studied regional cerebral blood flow (= test) and reactivity of acetazolamide injection (= retest) in 20 patients who had presented transient ischemic attacks (TIA). The cerebral blood flow was measured by the atraumatic Xenon 133 inhalation method and single photon emission tomography using a specially dedicated tomograph (TOMOMATIC 64), allowing 3 tomographic levels (OM + 1, + 5, + 9 cm). Measurements were realized in a quiet, dark room. Acetazolamide (500 mg or 1000 mg) was injected intravenously immediately after the test, and the retest was performed 15 minutes after, in the same conditions. Results obtained from paired ROIS were analysed in terms of asymmetric index for the test, of relative reactivity for retest in regard of normal values established in a group of healthy volunteers. All patients had neurological examination, vascular explorations and CT scan. Six of the patients showed a bad reactivity (abolished or strongly decreased) which was evoked a significant hemodynamically stenosis, reflecting the loss of collateral capacity. In the other group results were diversified, and we classified these in 4 groups: "normal" (7), "luxury perfusion" (3), "limited infarction" (1), and "incomplete infarction" (3). When these groups were plotted versus duration of onset and delay between the last attack and the moment of the measurement, "incomplete infarction" clearly appears as a step between brief TIA (less of 1 hour) and "limited infarction". So rCBF and reactivity to acetazolamide are of major interest for the physiopathological classification of TIAs, but also for treatment and prognosis.

Acetazolamide↗
PubMed1986

Stable labelling of serum albumin microspheres with gallium-68.

A highly efficient and rapid technique for labelling serum albumin microspheres with 68Ga is described. Measurements of the in vivo stability of the radiopharmaceutical in the rabbit and the baboon show that less than 0.2% of the injected activity is eluted from the microspheres in 2 h.

Animals↗
PubMed1986

Mismatch between iodine-123 and xenon-133 SPECT rCBF measurement.

This report is concerned with the case of a man afflicted by multiple cerebral arteriovenous malformations. The rCBF measurement with Xe-133 inhalation was relatively elevated. However, I-123 iodoamphetamine imaging showed a relative reduction in radioactivity, and was a more accurate reflection of the clinical situation.

Amphetamines↗
PubMed1986

[Disruptions of hemispheric blood flow and deep cerebral hematomas].

Cerebral blood flow measurements with single photon emission tomography and 133Xe inhalation was performed in 18 patients with hematomas, 14 thalamo-capsular, 4 capsulo-lenticular. In thalamo-capsular cases and in standard conditions, ipsilateral hemispheric C.B.F. and contralateral cerebellar C.B.F. were decreased; a concomitant depression of frontal and temporal C.B.F. was often noted. A similar change was found in capsulo-lenticular cases, the frontal C.B.F. being however less depressed. An attenuation of interhemispheric asymmetry was often found after acetazolamide intravenous injection. A significant correlation was demonstrated between interhemispheric asymmetry index (AI) and frontal and temporal AI.

Aged↗
PubMed1985

Tomographic measurement of cerebral blood flow by the 68Ga-labelled-microsphere and continuous-C15O2-inhalation methods.

The measurement of cerebral blood flow (CBF) by continuous C15O2 inhalation has only been validated previously by indirect experimental protocols. In the present study using baboons, these measurements were compared directly with those obtained by injection of 68Ga-labelled serum-albumin microspheres in the left cardiac ventricle. Using a modified labelling technique, no elution of 68 Ga occurred in vivo. Both methods provided similar regional CBF values, which could be described by a significant linear correlation (CBFCO2 = 0.82 CBFmicrospheres + 5.7; P less than 0.001). The validity of the labelled-microsphere-injection method was verified. The feasibility of stable in vivo labelling of 68Ga to serum-albumin microspheres provides a reference method for organ blood-flow measurements using positron-emission tomography.

Animals↗
PubMed1985

[The association of asthma and gastroesophageal reflux: strategy of paraclinical studies].

This study was carried out on 104 patients of whom 94 were asthmatic and 10 patients presented with a spasmodic intractable cough; all presented with symptoms evocative of an associated gastro-oesophageal reflux (RGO). The clinical symptoms revealed a nocturnal cough (67%), cough preceeding asthma (46%) and heartburn in 60%. The asthma was severe (type III and IV in 89% of cases), or dependent on corticosteroids (37% of cases). pH monitoring of the oesophagus is the most sensitive examination (88% with positive results) slightly ahead of manometry and scintigraphy (both 81%), these examinations were clearly superior to radiographic examination (49%) and oesophageal fibroscopy (36%). The combination of pH monitoring and of scintigraphy enabled 98% of RGO cases to be identified by their clinical data. Medical treatment with Tagamet, Gaviscon and Primperan (alone or in combination) produced an improvement in the respiratory symptoms in 50% of the cases. Of the 14 surgically treated, 7 obtained an improvement in their respiratory symptoms. Seven of the ten patients with spasmodic cough were improved by medical treatment. Our study shows the frequency of oesophageal reflux in patients with severe asthma. In half of them RGO intervened as an aggravating factor and the medical treatment of RGO led to a clear improvement in the respiratory symptoms.

Adult↗
PubMed1984

[Scintigraphy in the evaluation of painful arthroplasties. Simultaneous use of technetium and gallium].

Fifty-nine patients with 60 painful hip arthroplasties were assessed by scintigraphy using M.D.P. 99m Te and 67 Ga bone scanning. The M.D.P. 99m Te bone scanning was very reliable with 100 p. 100 of positive results. However, it did not elucidate the cause of the pain. Sixty-seven Ga scanning, when positive, allowed the diagnosis to be orientated towards an infective cause. However in 6 out of 18, the scanning was negative despite a proved infection. The technical details are described by which quicker and safer results can be obtained.

Equipment Failure↗
PubMed1983

[A critical study of technetium 99m and xenon 133 lung scintigraphy in patients with cystic fibrosis].

During investigations for cystic fibrosis, 41 children, most of whom were aged 0 to 7 years, were submitted to lung scintigraphy with technetium 99m first and xenon 133 subsequently. This procedure ensured accurate location of pulmonary lesions. The reliability of the radio-isotopic study was assessed through comparison to conventional clinical and radiological criteria, arterial blood gas determinations and pulmonary function tests. Perfusion scintigraphy with technetium 99m labelled macroaggregated albumin (n = 90) was compared to functional parametrical xenon, 133 study (n = 25) (perfusion-ventilation). The degree of lung disease was evaluated during serial examinations in order to improve prognostic prediction. Technetium 99m scintigraphy proves a reliable and sensitive procedure which accurately reflects the patients' clinical status when it is performed in the absence of patent pulmonary superinfection. Xenon 133 scintigraphy, which is more difficult to perform and interpret, has the advantage of providing a topographic and quantitative evaluation of pulmonary blood flow and ventilatory efficiency.

Adolescent↗
PubMed1983

[Water diffusion and measurement of cerebral blood flow by C15O2 inhalation].

Measurement of local Cerebral Blood Flow (CBF) using the C15O2 continuous inhalation technique coupled with Position Emission Tomography (PET) rests on the assumption that the in vivo labelled water (H215O) of blood diffuses freely within the brain water pool. This requirement however, may be disputed: in the rhesus monkey, Eichling et al (1974) showed a linear relationship between the single-pass extraction of water (E) and CBF after intra-carotid H215O injection, such that E decreases as CBF increases. Such a limitation in water transport across the blood brain barrier has also been suggested to exist in man (Paulson, 1977). In order to verify its possible effects on measured CBF in baboons, simple computer analysis was performed comparing the data obtained with CBF values reported in similar experiments, but using a freely diffusible inert gas (133Xe). This allowed calculation of a water extraction index (IE), which was shown to decline as CBF increased. This result may be considered as a presumption of the part played by the limited water diffusibility on the final CBF values, but other factors must also be considered, such as the inescapable admixture of grey and white matter (partial volume effect), a limitation of present day PET technology.

Animals↗