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Biomedical subjects

M Stoian

Publications and source records attributed to M Stoian.

At least 109 records · Page 6Linked to original sources
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[Cancer of the upper gastric pole--possibilities and limitations].

An analysis of the cases encountered over the last 5 years revealed a high frequency of gastric cancers located in the upper pole area of the stomach. These represented 23% of all gastric cancers. The low number of cases with this localization that could benefit from gastric resection (38,7%), in contrast with distal locations (65,4%) suggest either late detection or high invading potential of these cancers. Oeso-gastric resection - the only efficient curative or palliative treatment - was adapted according to site and extension of the tumour in both organs. In 6 cases partial resection of the thoracic oesophagus was necessary, and in another 4 cases total gastrectomy was performed. In 8 patients upper polar resection - including the oesophagus - was satisfactory from the oncologic viewpoint, and was well-tolerated by the patients.

Adult↗
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Investigations on the presence of papova virus in certain forms of human cancer. Note I. Renal tumors and melanomas.

Within the framework of their research concerns regarding the presence of papova viruses in the human population of Romania, as well as the relationship between these viruses and certain forms of human cancer, the authors undertook an electron microscopic study of 4 renal tumors and 6 melanomas. No viral particles could be made evident in any of the sections examined. Viral SV-40 antigen was detected by indirect immunofluorescence reaction in kidney sections from a nephrosis case considered as control.

Antigens, Viral↗
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Investigations on the presence of antibodies to papova viruses in patients with different forms of cancer and in other categories of patients or apparently healthy subjects. Note I. Neutralizing antibodies to SV-40 in the cerebrospinal fluid of patients with brain tumors and chronic neurological diseases.

Neutralizing antibodies to SV-40 were detected in cerebrospinal fluid samples from 16 out of 43 patients with brain tumors and in 6 out of 20 patients with different nonmalignant chronic neurological diseases. The patients' age excluded the correlation with a vaccine-associated or occupational contact with SV-40. The results ascertain the occurrence of SV-40 or of an antigenically related virus in the population of Romania.

Antibodies, Viral↗
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Investigations on the presence of antibodies to papova viruses in patients with different forms of cancer and in other categories of patients or apparently healthy subjects. Note II. Hemagglutination-inhibiting serum antibodies to BK virus.

Hemagglutination-inhibiting serum antibodies to BK virus (BKV were detected in patients with different forms of cancer and in blood donors (positivity percentages: 67.04 and 57.78, respectively). No such antibodies were found in a group of children 1 to 14 years of age. The data point to the presence of a latent human infection with BKV in the population of Romania.

Adolescent↗
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Investigations on the presence of antibodies to papova viruses in patients with different forms of cancer and in other categories of patients or apparently healthy subjects. Note III. Hemagglutination-inhibiting serum antibodies to polyoma virus.

Hemagglutination-inhibiting antibodies to polyoma virus could be detected in sera from apparently healthy subjects, patients with nonmalignant respiratory diseases and patients with different forms of cancer. The positivity percentages (12.97, 12.92 and 16.36, respectively) and the titers recorded were lower than in the case of BK virus. The results obtained suggest a slight antigenic relationship between polyoma and BK virus.

Adolescent↗
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Virus--tumor host cell relationships. In vivo cocultivation of adenovirus type 5 and of SV40 in mouse Ehrlich ascites carcinoma.

Mouse Ehrlich ascites carcinoma (EAC) cells proved to be a semipermissive substrate for in vivo cultivation of adenovirus 5 (Ad5) and SV40. The multiplication of SV40 in EAC cells was facilitated by the coinfection with Ad5. As demonstrated by ID and EID reactions, the virus progens isolated at the first passage after the mixed infection of EAC cells with Ad5 and SV40 possess an antigenic mosaic with fractions characteristic of the parental viruses and of the cell substrate in which they had cultivated in vitro and in vivo. The progens gave positive seroneutralization and complement fixation reactions only with antiserum to SV40.

Adenoviruses, Human↗
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Presence of antibodies to human cytomegalovirus in patients with different forms of cancer and in other categories of subjects.

Complement fixing (CF) antibodies to the AD--129 strain of human cytomegalovirus (HCMV) were detected in patients with different forms of cancer, as well as in blood donors, in a proportion of 16.6% and 73.2%, respectively. The prevalence of CF antibodies to HCMV, strain AT--129, in the population of Romania is similar to that reported in other countries.

Adult↗
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Herpes virus infection and uterine cervix carcinoma. General considerations, personal experimental data and suggestions for a specific antiherpes adjuvant therapy.

The authors review some data of the literature and results of personal investigations that point out a relationship between human herpes simplex virus infection and the etiopathogeny of uterine cervix carcinoma. On the ground of these data the authors suggest a "specific antiherpes" adjuvant therapy in this form of human cancer.

Antibodies, Viral↗
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Serum antibodies to papova viruses (BK and SV 40) in subjects from the area with Balkan endemic nephropathy.

The presence of antibodies to BK virus and SV40 was investigated in 63 patients with Balkan endemic nephropathy (BEN) and in 83 apparently healthy subjects from the endemic area. Serum antibodies to BK virus were detected in 95.2% of the former and in 74.7% of the latter, high antibody levels being prevalent in the age groups 41-60 years. Antibodies to SV40 were absent in the BEN patients and their frequency in the healthy subjects (27.7%) was much lower than that previously recorded in healthy persons from other zones of Romania (40%). The results obtained plead for a prevalence of BK virus infection in the endemic area with BEN.

Adult↗
PubMedDate not supplied

Multiple viral and inframicrobial infections detected by immunofluorescence reaction in exfoliated cells from patients with eye or respiratory diseases.

The presence of viral (herpes 1 and 2, influenza A and B, parainfluenza 1, 2, and 3, adenovirus) and inframicrobial (Chlamydia, R. burneti and mycoplasma) antigens was investigated by indirect immunofluorescence reaction in exfoliated cells from 107 patients with chronic eye diseases and 77 patients with chronic respiratory diseases. Single or associated viral or inframicrobial antigens were detected in 80% of the former and in 60% of the latter patients. The proportion of multiple infections was of about 60% in both patient groups.

Adenovirus Infections, Human↗
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Investigations on the presence of papova virus in certain forms of human cancer. Note 2. Brain tumors.

Two serially transmissible tumors (metastatic lymphosarcomas) were induced in the hamster by inoculation of human brain tumor material--tissue homogenate from a malignized fibroma or DNA extracted from a meningioma. SV40 V antigen was made evident by indirect immunofluorescence in 4 out of 18 human tumors, while SV40 T antigen could only be demonstrated in the tumors experimentally induced in hamsters. Antibodies to SV40 T antigen were detected in 12 out of 60 patients with different tumors, in 1 out of 40 blood donors and in 7 out of 18 hamsters carrying experimentally induced tumors.

Adult↗