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Biomedical subjects

M Sudou

Publications and source records attributed to M Sudou.

6 recordsLinked to original sources
PubMed1996

Using outdoor exercise to decrease jet lag in airline crewmembers.

The effects of outdoor exercise on urinary excretion of the 17-hydroxycorticosteroids (17-OHCS), catecholamine rhythm, and sleep-wake patterns in cockpit crewmembers were investigated before, during and after jet travel between Tokyo and Los Angeles (8-h time difference). On the day following arrival at Los Angeles (day 3) 5 crewmembers exercised outdoors for about 5 h (exercise group, aged 47.2 +/- 6.8 yr), and 5 others volunteered to remain in their rooms and go shopping after the flight (control group, aged 47.4 +/- 1.5 yr). The timing of the acrophase of the 17-OHCS rhythm and sleep-wake patterns showed similar patterns of advance in the two groups on the day of arrival in Los Angeles (day 2) compared with that at baseline (B) in Tokyo. In the exercise group, the acrophase of the 17-OHCS rhythm tended to be delayed on day 3, and then phase-advanced on the day following outdoor exercise (day 4). The timing of acrophase of the 17-OHCS rhythm and sleep-wake patterns showed gradual delay on days 3-4 in the control group, and a significant difference (p < 0.01) was observed between the groups for the acrophase of 17-OHCS rhythm on day 4. These results suggest that outdoor exercise has some effects in hastening the resynchronization to a new environment of the circadian rhythm of the urinary 17-OHCS excretion.

17-Hydroxycorticosteroids↗
PubMed1993

Dosimetry and measured differential W values of air for heavy ions.

Heavy-ion irradiation systems were designed and constructed at two cyclotron facilities in Japan for use in various fields of radiation physics and radiation biology. A 135 MeV/u carbon beam as well as 12 MeV/u carbon and helium-3 beams were first used in experiments. We have established a systematic method for heavy-ion dosimetry at both high and low incident energies involving measurements of fluences. We also obtained differential W values (w) of air for those beams by comparing the results of fluence measurement dosimetry with ionization chamber dosimetry. The differential W values of air were found to be 36.2 +/- 1.0, 34.5 +/- 1.0, and 33.7 +/- 0.9 eV for 6.7 MeV/u carbon ions, 10.3 MeV/u 3He ions, and 129.4 MeV/u carbon ions, respectively. The w value for high-energy heavy ions approaches the W value for high-energy electron or photon beams. In ionization chamber dosimetry for a heavy-ion beam, we found a track-size effect. A difference in the track sizes of heavy ions in the gas and solid phases affected the output current of the ion chamber in the case of high-energy heavy ions.

Carbon↗
PubMed1988

Semisynthetic beta-lactam antibiotics. IV. Synthesis and antibacterial activity of 7 beta-[2-(hetero aromatic methoxyimino)-2-(2-aminothiazol-4-yl)acetamido]cephalosporins.

A series of 7 beta-[2-(hetero aromatic methoxyimino)-2-(2-aminothiazol-4-yl)acetamido]- cephalosporins have been synthesized and bacteriologically evaluated. Several substances in this series showed exceptional in vitro activity, especially those with a five-membered hetero aromatic substituent moiety at the 7-position and a quaternary ammonium group as the 3-function of the cephem nucleus. The most active derivative, 7 beta-[2-(imidazol-4-ylmethoxyimino)-2-(2-aminothiazol-4-yl)a cetamido]-3-(pyridiniomethyl)ceph-3-em-4-carboxylate (13a) was the most evenly balanced with respect to activity against Gram-positive and Gram-negative bacteria. Furthermore, 13 was stable to various types of beta-lactamases and had high affinities for penicillin binding protein-3 and -1Bs of both Escherichia coli and Pseudomonas aeruginosa.

Bacteria↗