High-performance liquid chromatographic determination of m-bis(chloroethyl)aminophenyl-L-alanine in plasma.
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Animals↗
Biomedical subjects
M T Gatti
Publications and source records attributed to M T Gatti.
Synthesis, antiinflammatory and antiarthritic properties of a new tiopronine gold derivative.
The synthesis of triethylphosphine gold complex with the alpha-mercaptopropionylglycine ethyl ester (compound 3) is reported. The new compound shows an antiinflammatory and antiarthritic activity superior to auranofin.
Animals↗
New isosorbide 5-mononitrate derivative with hypotensive activity.
Synthesis and pharmacological properties of the 5-fluoro-nicotinic ester with isosorbide-5-mononitrate 3 are reported. The new compound shows an in vitro activity on rabbit aortic helical strips five times higher than isosorbide-5-mononitrate. The hypotensive activity in guinea-pigs of 3 is markedly superior to that of 5-ISMN. In the rat 3 shows a bioavailability and an acute toxicity inferior to those of 5-ISMN after oral administration.
Animals↗
A method for studying expectorant action in the mouse by measurement of tracheobronchial phenol red secretion.
The paper reports a method for studying mucosecretolytic drugs in the mouse. After i.p. application of phenol red, part of the dye is secreted in the tracheobronchial tract and collected by lung washings with saline. The concentration of secreted phenol red is measured photometrically at 546 nm. All the most important expectorant drugs increase the tracheobronchial secretion of phenol red in the mouse. The ED50 values, calculated as mg/kg, show practically the same activity for N-acetylcysteine, Tiopronine, SF-1284 and S-carboxymethylcysteine, and a lower activity for Ambroxol and Sobrerol. The method was validated for reproducibility utilizing Tiopronine in many experiments performed over twelve months.
Animals↗
Synthesis and mucolytic-expectorant activity of 3-mercapto-2 oxo 1-pyrrolidinyl acetic acid derivatives.
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Animals↗
A non steroidal anti-inflammatory drug that stimulates prostaglandin release.
Diacetylrhein (DAR) is a new anti-inflammatory and anti-osteoarthritic drug. Studies with isolated lung preparation showed that DAR does not exert its action by inhibiting the arachidonic acid metabolism. Furthermore, the in vivo experiments showed that DAR, contrary to most anti-inflammatory drugs, induced an increase of prostaglandin-like substances in the rat exudates. The above results are substantiated by experimental evidence that in the rat this compound displays a dose-dependent protecting activity against indomethacin-induced gastric damage.
Animals↗
The writhing test with erythromycin.
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Analgesics↗
[Distribution and elimination of oxytetracycline in experimental animals. I. Tests on rabbits].
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Animals↗
[Influence of lysozyme on intestinal absorption of tetracycline].
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Adult↗
Effects of SF-482 on bile, gallstones formation and experimental hyperlipemias.
The effects of 3 alpha, 7 beta-dihydroxy-12-cheto-cholan-24-oic acid (SF-482) were compared with those of ursodeoxycholic acid on bile flow and composition, on gallstones formation and on experimental hyperlipemias. SF-482, like ursodeoxycholic acid, increases the bile flow and residue in normal and ethynylestradiol-treated rats. The two compounds increase the biliary excretion of bile acids and phospholipids with a desaturation of bile cholesterol. SF-482 and ursodeoxycholic acid decrease the incidence of gallstones in mice; both compounds are active in Triton WR-1339, in olive oil and margarine hyperlipemias in rats and in ethanol intoxication in mice. In general, SF-482 is more active than ursodeoxycholic acid.
Alcoholic Intoxication↗