Biomedical subjects

M T Hull

Publications and source records attributed to M T Hull.

60 records · Page 4Linked to original sources

PubMedDate not supplied

Ultrastructure of gastric myxofibroma with intracytoplasmic collagen.

Electron microscopy of a small mass removed from the stomach of a 65-year-old women demonstrated a myxofibroma composed of a pure population of fibroblasts, many of which contained intracytoplasmic, membrane-bound collagen fibers similar to those found in a few other human tumors and in certain experimental conditions. This ultrastructural documentation supports the hypothesis that pure fibrous neoplasms of the stomach do occur. Electron microscopy of gastric mesenchymal tumors almost always allows for confident differentiation among fibrous, neural, and smooth muscle neoplasms.

Aged↗

PubMedDate not supplied

Myelinoid lamellated cytoplasmic inclusions in human renal adenocarcinomas: an ultrastructural study.

Ultrastructural study of 2 human renal adenocarcinomas demonstrated abundant myelinoid lamellated cytoplasmic inclusions, which were restricted to the neoplastic cells. They were structurally similar to those reported in renal adenocarcinomas chemically induced in rats; to those described in human diseases involving defects in lipid metabolism, including Gm2 gangliosidosis, Fabry's disease, Nieman-Pick disease, and juvenile-type neuronal ceroid-lipofuscinosis. Similar inclusions have also been reported to be induced by several drugs, none of which were taken by these patients. The occurrence of these lamellated inclusions in 2 human renal adenocarcinomas reinforces the phenotypic similarity between nitrosomorpholine-induced renal adenocarcinomas in rats and some renal adenocarcinomas seen in humans.

Aged↗

PubMedDate not supplied

Hepatoblastomas: an ultrastructural and immunohistochemical study.

Seven hepatoblastomas were studied by electron microscopy, and four of these were studied by immunohistochemistry. Five tumors were purely epithelial, and two were mixed epithelial-mesenchymal. They showed a spectrum of cellular differentiation ranging from primitive epithelial cells to differentiated cells resembling adult hepatocytes. Glycogen, lipid, basal lamina, and canaliculi were present in all cases. Mitochondria with large, membrane-bound, amorphous inclusions were present in one tumor, and large, complex, basal cell processes were present in two tumors. Ultrastructural features most characteristic of hepatocytes were most common in fetal type hepatoblastomas. Immunoreactive chromogranin cells were present in two tumors, one of which also contained immunoreactive somatostatin cells. The somatostatin-positive tumor had cells with granules resembling those seen in somatostatin-containing cells of normal pancreas and somatostatin-containing neuroendocrine carcinomas. Other immunoreactive substances were present, including alpha 1-antitrypsin (four cases), vimentin (embryonal cells in four cases; fetal cells in three cases), low-molecular weight cytokeratin (embryonal cells in three cases; fetal cells in four cases), and high-molecular weight cytokeratin (embryonal cells in one case; fetal cells in two cases). Osteoidlike material was positive for epithelial membrane antigen, vimentin, and S-100 protein.

Carcinoma, Hepatocellular↗

PubMedDate not supplied

Urachal cystadenoma with abundant glycogen: ultrastructural study.

A cystadenoma arose in the urachus of a 32-year-old man. The mass was a multilocular cystic tumor filled with light yellow mucoid material. It was located in the anterior abdominal wall between the umbilicus and the dome of the urinary bladder. Overall, the mass was 14 cm x 8 cm x 5 cm, with the largest internal cyst being 6 cm in diameter. The lesion was characterized histologically by columnar cells with focal cellular and nuclear stratification. Ultrastructural examination revealed columnar cells with abundant glycogen, moderately pleomorphic microvilli without prominent filamentous cores, and apical mucin vacuoles. Nuclei had pleomorphic contours. An intact basal lamina was present. A similar urachal cystadenoma has not been described.

Adult↗

PubMedDate not supplied

Proliferating thymolipoma: ultrastructural, immunohistochemical, and flowcytometric study.

A superior-anterior mediastinal tumor was excised from a 50-year-old man. The 207-g mass was encapsulated and multilobulated. It contained adipose tissue and abnormal thymic tissue. In some areas the thymic tissue was characterized by cords and nests of epithelial cells lying within either the adipose tissue or a myxoid matrix. Other areas were characterized by cortical thymic tissue with increased numbers of epithelial cells. Foci of normal medullary tissue were present. The prominent epithelial cells were immunoreactive for cytokeratin and nonimmunoreactive for vimentin, S-100, chromogranin, and parathyroid hormone. Flow cytometry showed that the lymphocyte populations were consistent with a late cortical thymic phenotype. The tumor was diploid. By electron microscopy, the prominent epithelial cells had desmosomes and a few tonofilaments. The cytoplasm contained additional organelles including mitochondria, polyribosomes, and occasional lysosomes. Nuclei were oval and had relatively smooth contours, prominent nucleoli, and moderate quantities of heterochromatin. Basal lamina was present around many nests and cords of cells. This is the first such study of a tumor with this histology.

DNA, Neoplasm↗

PubMedDate not supplied

Aggressive chondroblastoma. Report of a case with multiple bone and soft tissue involvement.

A 14-year-old male had a recurrent chondroblastoma in his right talus which involved the right calcaneus and the soft tissue of that ankle. While the initial lesion had a typical, benign appearance, the recurrent lesion and the soft tissue nodules showed a significantly elevated mitotic rate. Although some extraosseous involvement by chondroblastomas may be secondary to soft tissue or hematogeneous seeding at the time of surgery, and aggressive variant of chondroblastoma appears to exist. Previous reports of these aggressive cases show a poor correlation between histologic appearance and biologic behavior. When objective quantitation of cytologic features such as mitotic rate are made, we believe that these features may serve as a marker for identification of those cases of chondroblastoma which have a propensity for aggressive behavior.

Adolescent↗