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Biomedical subjects

M T Hull

Publications and source records attributed to M T Hull.

At least 55 records · Page 3Linked to original sources
PubMed1983

Serum angiotensin converting enzyme activity in patients with histoplasmosis.

The association between increased serum angiotensin converting enzyme (ACE) activity and active sarcoidosis is well documented. During a recent outbreak of acute histoplasmosis, a disease that shares many of the clinical and roentgenographic features of sarcoidosis, we examined serum ACE activity. Twenty-one (25%) of 86 patients with histoplasmosis had increased serum ACE activity. There were neither roentgenographic nor other substantive clinical differences between the groups of patients with increased and normal ACE values. Therefore, an increase in serum ACE activity must not be assumed to be caused by sarcoidosis unless histoplasmosis had been excluded.

Acute Disease↗
PubMed1983

Immunohistochemical demonstration of altered functional differentiation of pancreatic tissue in sacrococcygeal teratomas.

The finding of teratomas with mature-appearing pancreatic tissue showing abnormal production of immunoreactive amylase appears to contradict earlier suggestions that somatic tissue in teratomas that appears mature also functions normally. It therefore seems judicious to study carefully both morphologic and functional characteristics of tissues in teratomas before utilizing them as experimental models of tissue differentiation, since at least in the case of human amylase, functional differentiation does not always follow morphologic differentiation.

Amylases↗
PubMed1983

Age-related changes in the cutaneous basal lamina: scanning electron microscopic study.

Scanning electron microscopy of human epidermal-dermal basal lamina demonstrated striking age-related changes. The basal lamina from abdominal skin was exposed in specimens from 26 humans by separation of epidermis and dermis after treatment with sodium bromide solutions. Transmission electron micrographs demonstrated the split to be in the lamina lucida. Scanning electron microscopy of mature epidermal-dermal junction and basal lamina showed distinct dermal valleys; tall, dome-shaped dermal papillae; and basal lamina arranged in prominent corrugations that tended to be oriented vertically on papillae and irregularly on interpapillary zones. Skin from subjects in their 7th through 10th decades demonstrated progressive loss of dermal valleys, flattening and widening of dermal papillae, and loss of basal lamina corrugations.

Adolescent↗
PubMed1982

Metastatic carotid body paraganglioma in von Hippel-Lindau disease. An electron microscopic study.

Pulmonary metastases from a carotid body paraganglioma developed in a patient with von Hippel-Lindau disease. On electron microscopic examination, these metastases consisted solely of chief cells that contained membrane-bound, dense-core granules and formed numerous cytoplasmic processes. These data support the hypothesis that the chief cell is the sole neoplastic cell in paragangliomas. Finally, to our knowledge, this clinical association of a malignant carotid body paraganglioma and pheochromocytoma in von Hippel-Lindau disease is unique.

Adolescent↗
PubMed1981

Glycogen-rich clear cell carcinoma of the breast: a light and electron microscopic study.

A glycogen-rich clear cell carcinoma arose in the breast of a 49-year-old woman. Light microscopic examination of the neoplasm revealed both intraductal papillary growth and stromal invasion. Electron microscopic examination demonstrated neoplastic cells that contained massive quantities of nonmembrane-bound particulate glycogen and that formed numerous acini. Apically, these cells formed microvilli; laterally they formed tight junctions and desmosomes. Morphologic features of this neoplasm are similar to those of the fetal breast and to some other clear cell carcinomas arising elsewhere in the body.

Adenocarcinoma, Papillary↗
PubMed1981

Ultrastructure of Buschke-Loewenstein tumor.

A 44-year-old man suffered a Buschke-Loewenstein tumor that was treated by distal penectomy. Ultrastructurally, this tumor showed widened intercellular spaces, prominent microvilli, decreased numbers of and incompletely developed desmosomes, decreased tonofilaments, cytoplasmic dense bodies, enlarged nucleoli and annular nuclear bodies. These ultrastructural features are quite similar to those of squamous carcinoma but are dissimilar to those of condyloma acuminatum and, to a lesser extent, verrucous carcinoma. These data suggest that electron microscopy may be useful in differentiating the neoplastic Buschke-Loewenstein tumor from large condyloma acuminatum.

Adult↗
PubMed1981

Surgical treatment and course of pulmonary pseudotumor (plasma cell granuloma).

A number of benign clinical conditions of the lung may simulate carcinoma. Pulmonary pseudotumor, which falls into this category, may present as a mass lesion or rarely as an infiltrate. This paper describes six patients with pulmonary pseudotumor, their surgical treatment and, for the first time, a postoperative follow-up ranging from 1 to 10 years. Histories of heavy cigarette smoking were obtained in four. Discrete masses on x-ray films were present in five, and one had localized infiltrates. Lobectomy was performed in two and partial mass resection or removal of tissue for biopsy in four. In this latter group, postoperative x-ray films from 1 to 10 years later showed complete disappearance of the lesions. No subsequent malignant lesion developed, and there was no early or late mortality. This unique experience documents for the first time the natural course of pulmonary pseudotumor. On the basis of this and isolated reports in the literature, pseudotumor must be carefully differentiated from carcinoma. Once diagnosed, as minimal lung resection as possible is indicated.

Adult↗
PubMed1980

Signet-ring cell carcinoma of the breast: a clinicopathologic study of 24 cases.

Twenty-four cases of signet-ring cell carcinoma of the breast are presented. These represented 4.5% of 535 cases of surgically treated breast cancer at Indiana University Medical Center. Twelve cases were associated with ductal carcinoma, nine with lobular carcinoma, one with colloid carcinoma, and four were pure signet-ring cell carcinoma. The mortality rate, incidence of axillary lymph nodal metastases, and number of involved lymph nodes were greater in cases of signet-ring cell carcinoma than with other forms of mammary carcinomas without signet-ring cells. It is proposed that signet-ring cell carcinoma can manifest as a pure lesion or as a variant of ductal, lobular, or colloid carcinoma, and that it is an aggressive histologic variant of mammary carcinoma.

Adenocarcinoma, Mucinous↗
PubMed1980

Mixed leukemia, lymphatic and myelomonocytic.

A 76-year-old man who was admitted to the hospital had mixed lymphocytic and myelomonocytic leukemia. A review of the world literature revealed 21 previously reported cases dating from 1906. Most of these patients had initial chronic lymphocytic leukemia with the subsequent development of myeloblastic or monoblastic leukemia. In some patients, development of the second form of leukemia may have been related to prior exposures to ionizing radiation or alkylating agents.

Aged↗
PubMed1979

Familial islet cell tumors in Von Hippel-Lindau's disease.

Von Hippel-Lindau's Disease is an hereditary disorder characterized by the development of hemangioblastomas of the cerebellum and retina and a variety of cystic and neoplastic lesions of other organs such as renal cell carcinoma and pheochromocytoma. In a single generation of a family with Von Hippel-Lindau's disease, all four siblings developed lesions classically associated with the complex. Additionally, two of the four developed islet cell tumors of the pancreas, one in one patient and five in the other. While a familial incidence of islet cell tumors is known in multiple endocrine adenomatosis, type I and Zollinger-Ellison syndrome, such a familial occurrence has been heretofore unrecorded in the Von Hippel-Lindau complex.

Adenoma, Islet Cell↗
PubMed1979

Multiple pulmonary fibroleiomyomatous hamartomata in childhood.

A 9-yr-old girl with a history of rhabdomyosarcoma developed multiple pulmonary fibroleiomyomatous hamartomata. This clinical setting illustrates the tendency of these hamartomata to clinically mimic metastatic tumors. Further, this case represents the first description of multiple pulmonary fibroleiomyomatous hamartomata in a pediatric age group, and finally, in this clinical setting, supports the concept that these hamartomata represent a distinct entity apart from benign metastasizing uterine leiomyomata.

Abdominal Neoplasms↗
PubMed1978

Intranuclear filaments in a soft tissue sarcoma.

Intranuclear filaments aggregating into rodlike structures were found in cells of an undifferentiated soft tissue sarcoma in a child. Similar structures have been uncommonly described in human neoplasms, and uncertainties exist concerning the nature of the inclusion bearing cells in previous reports. The filaments were found to be resistant to mild trypsin digestion. Review of the pertinent literature indicates that these structures may represent the structural manifestation of a highly specialized functional state, rather than a degenerative phenomenon or an artifact. A certain selectivity of occurrence has also been noted. It is therefore plausible to speculate that intranuclear filaments may eventually constitute a morphologic criterion of interest for new tumor classifications.

Adolescent↗
PubMed1978

Morphologic abnormalities in a case of malignant hyperthermia.

An 8-year-old boy underwent general anesthesia and experienced an episode of malignant hyperthemia, characterized by elevated temperature, cardiac arrhythmias, markedly elevated serum enzymes (SGOT, LDH, and CPK), proteinuria, and hemoglobinuria. Sixty-six days after anesthesia a skeletal muscle biopsy was obtained for examination by electron and light microscopy, which showed skeletal muscle cells with abnormally numerous mitochondria, enlarged, and variable in shape. Some contained abnormal cristae. There were more lysosomes than normal, and lipofuscin was increased in quantity. Myelin-like bodies were also present. Previous reports of muscle abnormalities are reviewed and compared with the data in this case.

Child↗
PubMed1977

Granulocytic sarcoma of the cervix as a primary manifestation: case without overt leukemic features for 26 months.

A case of granulocytic sarcoma involving the uterine cervix as primary manifestation without evidence of leukemia is presented. It was followed by neurological symptoms 19 months later and a right breast mass 26 months after the initial cervical lesion, but still with no evidence of leukemia. Two years and four months after onset, soft tissue and skin nodules developed and rare blastic cells appeared on peripheral blood smear. The patient terminally developed acute granulocytic leukemia with a rapidly downhill course. The differential diagnosis of granulocytic sarcoma and histiocytic lymphoma is discussed. The literature is reviewed with emphasis on the clinical and pathological problems that arise when the tumor presents in an unusual location without peripheral blood manifestation of leukemia.

Aged↗
PubMed1976

Idiopathic pulmonary hemosiderosis: evidence of capillary basement membrane abnormality.

Electron microscopic examination of a lung biopsy obtained from a child in the active stage of idiopathic pulmonary hemosiderosis disclosed prominent changes in the basement membrane of alveolar capillaries. Review of the pertinent literature showed that a structural defect of lung capillary walls in this disease has been proposed in the past mainly on theoretic grounds but not adequately documented at the ultrastructural level. Concentric multilayering of pulmonary capillary basal lamina, one of the changes observed in our material, is a rare phenomenon in this location, although one that has been well described in extrapulmonary microcirculatory beds and is probably a nonspecific reaction to vascular injury. The conceptual difficulties attending a definition of idiopathic pulmonary hemosiderosis are breifly discussed.

Basement Membrane↗
PubMedDate not supplied

Clear cell carcinoma of the larynx A variant of mucoepidermoid carcinoma.

A case of clear cell carcinoma of the larynx is presented. By light microscopy the lesion was composed mainly of sheets of clear cells containing intracytoplasmic mucin and glycogen. Glandular lumina, tonofilaments, and desmosome-tonofilament complexes were observed on electron microscopy. The presence of these features established that this unusual neoplasm was a clear cell variant of mucoepidermoid carcinoma.

Adenocarcinoma↗