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Biomedical subjects

M Tichý

Publications and source records attributed to M Tichý.

At least 109 records · Page 6Linked to original sources
PubMed1990

Effect of ethanol on the urinary excretion of mandelic and phenylglyoxylic acids after human exposure to styrene.

Administration of ethanol in several doses during human exposure to styrene can inhibit the urinary mandelic and phenylglyoxylic acid excretion in a way similar to that reported when ethanol was administered as a single dose. Sensitivity to this inhibitory effect has been found to differ with individual subjects. Differences in long-term consumption of ethanol resulting in different induction of the oxidizing enzymes are suggested to account for this finding. Intra-individual variation in the influence of acute ethanol ingestion on the excretion rate of the mentioned acids can also occur. The habit of drinking ethanol might be important, even for partial redirection of the styrene metabolism from styrene glycol oxidation to styrene glycol conjugation with beta-glucuronic acid and/or sulfate. The consequences of these observations for the occupational hygiene practice are briefly outlined.

Adult↗
PubMed1990

Importance of determining lysozyme in colorectal cancer.

In the last few years, an increase in the incidence of malignant tumours of the large bowel and the rectum has been observed in all advanced countries. Intensive search is therefore going on for biochemical and immunochemical markers which would help early diagnosis and monitoring of this disease. The most frequently used markers in colorectal cancer are CEA, CSi, CRP, CA 19-9 and sialic acid. The present study points out the possibility and advantage of using lysozyme determination in serum as another marker in patients with colorectal cancer.

Aged↗
PubMed1990

Index of light kappa/lambda and lambda/kappa chains in monoclonal gammopathies.

Concentrations of the light chains kappa and lambda were determined by simple radial immunodiffusion in the blood sera of 437 patients with monoclonal gammopathies. The kappa/lambda index was calculated in monoclonal gammopathies with the antigenic type of kappa light chains, while in monoclonal gammopathies with the antigenic type of lambda light chains the lambda/kappa index was calculated. The results obtained in malignant monoclonal gammopathies were compared with the results obtained in monoclonal gammopathies of undetermined significance for IgG and IgM paraproteinemias. Differences of high statistical significance were established (for IgG and IgA p less than 0.001, for IgM p less than 0.005) and thus the light-chain index can be used as another marker in differential diagnosis of monoclonal gammopathies.

Aged↗
PubMed1990

Blood-group related antigens A and B in gastric cancer.

Using monoclonal antibodies the expression of blood group antigens A and B was studied by the method of indirect immunoperoxidase reaction in a series of 48 gastric carcinomas classified by Laurén's criteria into diffuse and intestinal types. Expression in intestinal and diffuse types of carcinoma differed significantly in patients of blood group A and AB. Intestinal type was characterized by a marked heterogeneity of expression of blood group antigens, while diffuse type displayed a homogeneous expression. The observed differences testify the validity of Laurén's classification. A more frequent staining of supranuclear regions of the cytoplasm of tumor cells in intestinal type carcinoma was recorded with the monoclonal antibody HE 10 (reacting with antigenic determinants A and H of type 3 and 4). A possible prognostic significance of this finding is discussed.

ABO Blood-Group System↗
PubMed1990

[The first period in the history of the Institute for General Biology].

Of the history of the Institute for General Biology, School of Medicine, Comenius University, the study deals with the first period, namely the years 1923-1945. The institute greatly benefited from the activities of Prof. MUDr. Zdenĕk Frankenberger who established it and was its Head in the first year of its existence. From 1925 till 1943 the institute was directed by Prof. MUDr. Jozef Florian Babor. Professor Babor's main interest was focused on malacology and he achieved international reputation in this field of zoology. He investigated the flora and fauna of Slovakia, was engaged in limnology, and cooperated with Professor Frankenberg in the field of anthropology and primatology. Over these years, prof. Vojtech Nábĕlek and MUDr. Bohumil Krajnik greatly contributed to the activities and development of the institute along with Prof. Babor. The Institute for General Biology was already in the first period of its existence reknown not only for its teaching activities but was also internationally appreciated in the medical, biological and historiographic community.

Academies and Institutes↗
PubMed1990

[The life and work of Professor Zdenĕk Frankenberger, the founder and first head of the Institute of Histology and Embryology at the School of Medicine of Comenius University in Bratislava].

The life and work of Prof. MUDr. Zdenek Frankenberger is presented with the main focus on the 16-year period of his activities in Slovakia. His contribution to the history of the Bratislava School of Medicine is great both with regard to his activities both as its founder and excellent teacher of generations of Slovak doctors. He was striving hard to establish the Institute of Histology and Embryology whose first head he became. He participated in the establishment and development also of other institutes of the School of Medicine. An analysis of his remarkable and voluminous scientific work displays the extent of his education, knowledge and interests. His studies covered a broad range of scientific problems in the field of histology, microscopic anatomy, embryology, comparative anatomy and anthropology. Yet he was engaged also in faunal studies and became a reknown expert in entomology. Prof. Frankenberger contributed considerably to the executive work of the Medical School and was its vice-dean and dean.

Czechoslovakia↗
PubMed1990

Expression of blood group A and B antigens in gastric cancer examined by monoclonal antibodies.

Fourty-eight patients with gastric carcinoma were histologically examined and classified according to Laurén as intestinal or diffuse type. Employing monoclonal antibodies, in all samples the expression of blood group A and B antigens was studied using the method of indirect immunoperoxidase reaction. In patients with blood groups A and AB the comparison of expression revealed marked differences between the intestinal and diffuse type carcinomas. In the intestinal type, the expression of the blood group antigens was highly heterogenous, while diffuse type carcinomas displayed a homogenous expression. The obtained differences support Laurén's classification. The staining of supranuclear regions of tumor cells by the monoclonal antibody HE 10 (which reacts with antigenic determinants A and H of type 3 and 4) was found more frequently in intestinal type carcinomas. The possible prognostic significance of these findings is discussed.

ABO Blood-Group System↗
PubMed1990

IgG1-4 subclasses in paraproteinemias.

The concentration of IgG1-4 subclasses was determined in a series of 10 IgG1 paraproteinemias (5 multiple myelomas and 5 non-myeloma paraproteinemias) and in a series of 11 IgA paraproteinemias (7 multiple myelomas and 4 non-myeloma paraproteinemias). In the group of IgG1 myelomas, deficiency was established in the subclasses IgG2-4, in the group of IgA myelomas, deficiency was proved in all IgG1-4 subclasses as compared with non-myeloma paraproteinemias. Decreased IgG heterogeneity in IgG1 myelomas was demonstrated by the method of isoelectric focusing.

Adult↗
PubMed1990

[Plasmocellular leukemia with IgD paraproteinemia].

The authors describe the case of an 80-year-old woman with a plasmocytoma IgD-lambda, which developed into plasmocellular leukaemia. The laboratory finding reminded at first of chronic lymphatic leukaemia. The correct diagnosis was assisted by marked leucocytosis with the release of a major number of plasmatic cells into the peripheral blood stream. The finding was confirmed on the basis of sternal puncture, cytochemical examination, immunochemical examination of the blood and urine and X-ray of the skull. Treatment led to marked clinical and laboratory improvement. The patient died, however, from pneumonia three months after establishment of the diagnosis. Post-mortem examination revealed an extensive infiltration of many organs and a myelomatous kidney. The authors present some differential diagnostic reflections on plasmocellular leukaemia.

Aged↗
PubMed1990

[Differences in the expression of blood group antigens A and B in carcinoma of the stomach in relation to Laurén's classification].

Expression of blood group antigens A and B was studied in a group of 48 gastric carcinomas (classified according to Laurén as intestinal and diffuse types respectively) by monoclonal antibodies in an indirect immunoperoxidase method. Results could be summarized as followings: 1. Significant difference concerned the expression of blood group antigens A and AB. Intestinal type was characterized by striking heterogeneity of expression and more pronounced deletion of antigens. Diffuse type had a homogenous expression and a distinctly smaller deletion. 2. Supranuclear immunoreactivity with monoclonal antibody HE 10 in intestinal type carcinoma may have a prognostic importance. This expression could not be observed in diffuse type carcinoma.

ABO Blood-Group System↗
PubMed1989

[Immunologic examination of the blood in the differential diagnosis of acute gouty arthritis and rheumatoid arthritis].

In 16 patients with acute gouty arthritis, 30 IgM RF seropositive cases of rheumatoid arthritis (RA) and 20 IgM RF seronegative cases of RA the values of 14 indicators of antibody and natural immunity were assessed in serum. The assembled data were evaluated by step-wise discrimination analysis. This made it possible to select consecutively signs important for the differentiation of acute gouty arthritis from IgM RF seropositive RA (immunocomplexes, beta-2 microglobulin, C3) and for its differentiation from IgM RF seronegative RA (IgE, C3, transferrin, free SH groups). Thus obtained classification functions make it possible to classify correctly, random subjects with a probability of 76.7-93.7%.

Acute Disease↗
PubMed1989

The morphogenesis of human sphincter urethrae muscle.

The morphogenesis of the sphincter urethrae muscle was studied in human ontogeny. Muscles of 65 embryos and fetuses, 7 newborns, 3 children and 3 adults of both sexes were examined histologically and by means of microdissection. Three developmental stages can be recognized in terms of morphogenetic events, histogenesis and development of sexual dimorphism. In the sexually indifferent stage (up to approximately 50 mm crown-rump length), the sphincter urethrae primordium is formed by a shallow arch apposed only to the ventrolateral wall of the urethra. The primordium extends from the level of the urogenital diaphragm up to the vesicourethral transition. It consists of a condensation of mononuclear cells. Myotubes appear in fetuses of 30 mm crown-rump length. During the second stage (until birth) sexual dimorphism develops in conjunction to the formation of the prostate and vagina. In this stage, the sphincter urethrae muscle fibres gradually extend to the posterior wall of the urethra. At the same time cranially situated muscle fibres project to the lateral wall of the prostate, whereas in females caudally located muscle fibres attach to the lateral wall of the vagina. In this way the sphincter achieves the sexually distinct form. The definitive arrangement develops in the third morphogenic stage (after birth), in which a complete muscle ring is formed by encircling the urethra in the infraprostatic part in males and in the upper, larger part of the sphincter in females. The sphincter urethrae muscle is located inside the sling of the puborectalis muscle in both sexes, but no muscle fibres connect them to one another.(ABSTRACT TRUNCATED AT 250 WORDS)

Female↗
PubMed1989

[Differential diagnosis of acute myocardial infarct in hypothyroidism].

The authors demonstrate the case of a female patient with hypothyroid myopathy where they recorded repeatedly a rise of enzymes used for the diagnosis of acute myocardial infarction, whereby myocardial infarction was not revealed. The authors followed up the disease for two years. They evaluated the relationship between the state of substitution and the activity of the mentioned enzymes and myoglobin.

Aged↗
PubMed1989

[Clinical importance of changes in antibody immunity in gout].

In 77 patients with gout (16 with acute attacks and 61 during an attack-free period), in 30 healthy subjects, 30 patients with IgM RF serum positive rheumatoid arthritis (RA) and 20 cases of IgM RF serum negative RA the authors examined serum values of 10 parameters of antibody immunity: IgA, IgG, IgM, IgD, IgE, beta-2 microglobulin (beta-2 MG), immunocomplexes (IK), IgM RF/LFT, IgM/RF/HAT and ANA/IF. Data obtained by quantitative analyses were processed by stepwise discrimination with the consecutive selection of characteristics significant for the differentiation of the investigated groups and by assessment of classification functions which make it possible to classify individuals selected at random. The authors consider the following particularly important from the clinical aspect: acute gouty attack--IgM RF serum positive RA (IK and beta-2 MG), attack-free stage of gout--healthy subjects (IgA, IgG, IgM, IgD, IK, IgE). IgM RF were detected in 5/77 patients with gout, ANA/IF not in a single patient.

Acute Disease↗
PubMed1989

[The development and beginnings of otorhinolaryngology at the Comenius University Medical School in Bratislava].

The subject of the paper is the history of development and the beginnings of otolaryngology at the Medical Faculty, Comenius University in Bratislava. A special feature of the process was that in Bratislava two separate clinics were established: an otological and rhinolaryngological clinic. The founder and first head of the otological clinic founded in 1932 was professor MUDr. Pavel Záviska and the first head of the rhinolaryngological clinic was professor MUDr. Bedrich Wiskovský. At the end of 1938 the two departments fused and professor Wiskovský was the head of the new department.

Czechoslovakia↗