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Biomedical subjects

M Trede

Publications and source records attributed to M Trede.

At least 91 records · Page 5Linked to original sources
PubMed1986

[Which acute abdominal diseases must have urgent surgery?].

To answer this question, a prospective study of 342 patients was carried out. 18% could be discharged after exclusion of any serious disease; 63% were admitted for observation and in some cases delayed operation; in 19% of cases an emergency operation was performed (mostly for appendicitis and obstruction). The decision for early operation depended largely on the simple methods of history and repeated examination. More complicated diagnostic methods were helpful in a few cases only.

Abdomen, Acute↗
PubMed1985

[Aorto-intestinal and paraprosthetic fistulas. A rare differential diagnosis of gastrointestinal hemorrhage].

Secondary aorto-intestinal or paraprosthetic fistulas had developed in seven patients after implantation of an angioprosthesis. In six cases, the fistula was located in the duodenum, in each case after a bifurcation bypass had been established, whereas in one case the fistula occurred in the area of the caecum (unilateral aortofemoral bypass as preliminary operation). Gastrointestinal bleeding was the initial sign in five patients, preceding in each case the final massive haemorrhage as a typical premonitory haemorrhage by several days. A secondary aorto-intestinal fistula must be assumed if there is a constellation of acute gastrointestinal bleeding, sepsis or fever and previous aorto-iliacal bypass operation, unless it is possible to confirm some other source of haemorrhage by endoscopy. The present-day standard therapy consists in occluding the intestinal fistula opening, removal of the entire prosthetic material and, if necessary, establishment of an extra-anatomic axillofemoral bypass.

Abscess↗
PubMed1985

[Experiences with ileoanal anastomosis and ileal pouch formation following colectomy and proctomucosectomy].

Since 1981 12 patients (11 adenomatosis coli = AC/1 ulcerative colitis = CU) had a colectomy and mucosal proctectomy with ileo-anal anastomosis (IA) and formation of an ileal-S-pouch (IP). The mean age of 7 men and 5 women was 33 years (21-46 yrs). We preferred the synchronous abdomino-peranal operation. Protective ileostomy was closed after a mean of 4.6 months in 11 patients. Postoperative complications: IA-insufficiency = 4, sacral abscess = 1, stenosis = 3, ileus and reoperation = 2). Late results: spontaneous defecation: 11/11, continence 10/11, evacuation 6-8/day. This operative procedure seems to be good for AC and CU.

Adult↗
PubMed1985

The surgical treatment of pancreatic carcinoma.

This is a report on 501 pancreatic and periampullary cancers treated at the Mannheim Surgical Clinic during the past 11 years. Modern diagnostic measures (computerized axial tomography, endoscopic retrograde cholangiopancreatography, and angiography), while failing to detect the early operable tumors, have contributed to a rise in the rate of resectability of cancers of the pancreatic head (from 5% to 21%). Tactical problems of surgical treatment include the extent of resection required (total or partial), the rationale of preliminary biliary decompression, the symptomatic but unidentified mass in the head of the pancreas, and concomitant celiac artery stenosis. In 118 duodenopancreatectomies performed for cancer and 81 performed for severe and complicated chronic pancreatitis, the operative and hospital mortality rate was 2.5%. Of the 28 patients whose pancreatic resections for cancer occurred more than 5 years ago, 10 reached the 5-year survival limit.

Adult↗
PubMed1984

[Stress tolerance of pancreatic cancer patients].

The patient with pancreatic carcinoma is tested in 4 phases: during diagnosis the non-invasive procedures take precedence; as regards pre-operative treatment, primary biliary decompression seems to bring no advantages in the icteric patient; the indications for various treatment forms show a resectability rate of only 13%; the final test is the mortality rate of the treatment selected: in 200 duodenopancreatectomies it amounted to 2.5%.

Adult↗
PubMed1982

[Programmed after care of breast cancer. Results of a follow-up model after 2 years later].

In two years 359 patients with breast cancer were evaluated in a cooperative follow-up programme in which the organisation and documentation were done in hospital, the medical care and investigations by the family doctor. 72% of 316 evaluable patients remained in regular control. 63% chose the family doctor for follow-up while the others preferred hospital. In the first year 71-80% attended their appointments, in the second year 60-74%. Statistically significant parameters for detection of metastases were the following: general condition, local signs, palpable lymph nodes, markedly increased ESR, alkaline phosphatase, chest radiograph, and bone scan. Cumulative freedom from recurrence in the whole group diminished from 1.0 to 0.631 in 25 months, cumulative survival from 1.0 to 0.876 in 20 months. In both groups there were significant differences between stages I, II and III. Forty patients (16%) out of 250 developed a recurrence within 2.25 years, in five (2%) a second carcinoma developed. There was a high proportion of local recurrences (20 out of 40) and these often led to generalised disease (11 out of 20).

Aftercare↗
PubMed1982

Adjuvant 5-fluorouracil and BCNU chemotherapy in gastric cancer: 3-year results.

One hundred-three patients with a potentially curative operation of a histologically proven gastric cancer were randomly assigned to a control and chemotherapy group after stratification according to tumor stage II and III. Chemotherapy courses with 5-fluorouracil (10 mg/kg/day) and BCNU (40 mg/m2/day) for 5 days were administered eight times in 6-8 week intervals. Age, sex, and tumor location were matched in the chemotherapy and control groups. Five patients declined treatment after randomization. Three years after initiating the study, the tumor has recurred in 38 of the 103 patients. There were 21 recurrences of 54 controls and 14 recurrences of 44 patients who received chemotherapy, and 17 and ten deaths, respectively, due to tumor relapse. The results of our study to data show a high degree of statistical probability that adjuvant chemotherapy with the regime used has no influence on the recurrence-free interval and survival time in gastric cancer.

Carmustine↗