[Healing disorders in aseptic wounds].
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Biomedical subjects
Publications and source records attributed to M Trede.
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Cystic diseases of the adrenal glands, which were thought to be rare, are being found more frequently nowadays by means of sonography and computer tomography. Our experience of fifteen cases is reported; of these, ten were confirmed at operation. Contrary to expectations based on the relevant literature, only one of the operated cases proved to be an endothelial cyst of lymphangiomatous origin. All other patients had pseudo-cysts of the adrenals. These are due to bleeding into a normal or tumour-containing gland. About one quarter of the pseudo cysts showed circular calcification on the plain films, although the incidence of this is given as 8-15% in the literature. The cystic nature of these lesions can be readily demonstrated by ultrasound or CT. The latter also provided information concerning the wall of the cyst and of the remaining adrenal tissue. An aspiration biopsy of the cyst can be carried out under ultrasound or CT control; cytological examination will confirm the benign nature of the lesion. A benign lesion without symptoms requires no further diagnostic or therapeutic measures. If there is hypertension, as may occur with a cystic phäeochromocytoma or lymphangioma, angiography is still indicated. Hormone assays are possible following catheterisation of the vena cava combined with adrenal phlebography. The origin and extent of a malignant pseudo-cyst can be demonstrated by arteriography, if this information is lacking following CT.
Resection of liver metastases was performed in 31 patients from 1973 to 1980. There were 25 atypical partial resections and 6 anatomical hemihepatectomies. In agreement with some large collective there was a relatively favourable prognosis after resection of solitary metastases or of those restricted to a lobe or segment when the primary tumour was colorectal. Surprisingly favourable individual results were also obtained with en-bloc resection of malignant gastric tumour in which the liver had been infiltrated locally. Other oncological methods of treatment are inferior to surgical intervention and should only be used for inoperable liver metastases in the course of controlled clinical studies. Regular postoperative control with exhaustive application of all diagnostic possibilities for discovering metastases are justified in view of the therapeutic consequences only with respect to primary tumours in the colorectal region.
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From January 1970 to September 1980 101 patients with early gastric carcinoma were operated. The youngest patient was 33 years, the oldest 83 years old. The incidence was highest in the 7th decade. Two thirds of all early gastric carcinomas were localized in the prepyloric region. 4 of these tumours were found in the gastric stump after previous B II resection. 3 multifocal carcinomas were found in our series. According to Laurën's classification 70 early gastric carcinomas were of the intestinal type, 28 of the diffuse type, in three cases a correct classification could not be performed. The predominant operative procedure was the B II resection in 71 patients. Further methods were total gastrectomy 15, B I resection 4, proximal resection 4, endoscopic polypectomy 3, Maki-resection 2, local excision 2. In the postoperative period complications occurred in 9 patients; four of them died. The 5-years survival rate was 72%. In 4 patients a recurrence of the malignancy was detected, in 3 of them another early gastric carcinoma and in 1 an advanced gastric carcinoma.
A report on urologic complications of Crohn's disease observed in 9 out of 51 operated patients. Primary resection of the diseased bowel segment is of decisive importance in the treatment of these vesicoenteric fistulae or ureteric stenoses. Additional ureterolysis is required only in case of extensive retroperitoneal fibrosis.
Report of the result of CT and venography in 12 patients with suspected adrenal disease, venography being combined with selective blood sampling for hormone analysis. In one patient CT showed a 1.6 cm big pheochromocytome in the left adrenal gland, not demonstrated by venography, but proven by analysis of the blood sample. Both methods showed hyperplasia of both adrenals in one patient with Cushing Syndrome with elevated Cortisol levels found in the analysis of the blood smples. Of 3 patients with hyperaldosteronism, venography was able to demonstrate 2 Conn adenomas, not seen on CT; whereas CT showed the third 2 X 1.5 cm big Conn adenoma hidden in an enlarged adrenal gland. Hormone analysis was helpful in 2 of these cases, while in the third it was misleading. The authors believe that both methods should be employed to localise over adrenal disease with endocrine activity.
We report on complications following vascular surgery of the aorto-iliac segment. Recurrent occlusions were observed in 15.3% of our cases. The operative mortality was 1.8%. The etiology of anastomotic false aneurysms is discussed. One deep graft infection was successfully managed. Ureteric lesions following aortic surgery are exceptional. No ischemic colitis occurred among our patients. Two cases of aorto-intestinal fistulae are described.
In 90 patients a total of 100 reconstructions of the carotid artery had been performed between 1972 and 1977. No patient died from the operation, 3 suffered central nervous complications, and 33 had transitory defects of cranial nerves. These defects were reversible in all but two patients. After an average observation period of 20 months 11 patients had died (6 from cardiac infarction, 2 from stroke, and 3 from unknown reasons). Of the 31 patients with clinical stage II, 24 were without symptoms, 5 had only rare transient ischaemic attacks, and two patients had the same frequency of attacks as preoperatively. Among the 39 stage III patients 35 showed complete or partial regression of symptoms whereas 4 had had repeat strokes. 55 of the 59 corrected stenoses were patent as shown by Doppler ultrasound. In contrast attempts to correct complete internal carotid artery occlusions showed unsatisfactory results.
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A solitary pyogenic liver abscess usually requires open surgical drainage. Digital exploration of the cavity is important for eliminating any loculations and avoiding complications after the drainage procedure. Chronic liver abscesses which are enclosed by a fibrous capsule and thus may simulate a neoplastic tumor are best treated by atypical liver resection close to the abscess or by a procedure similar to pericystectomy. Early radical operation is indicated for a complicated liver abscess whenever two drainage procedures have failed and the patient's condition is deteriorating. In such a case the development of sepsis and (or) multiple abscesses caused by an internal fistula to the bile duct system are a potential and increasing danger. Anatomical liver resection, though the most radical operation, carries a comparatively low risk as its mortality rate is less than 10%. The prognosis of solitary abscess has improved during the last decade due to an earlier diagnosis and adequate surgical drainage in combination with antibiotics. Anaerobic liver abscesses have the best prognosis.
The 240 reconstructions of the femoral artery, performed within the last 4 1/2 years, involved 26 patients (27 bypasses) with combined femoral and peripheral vascular occlusions. The bypasses were connected with a segment of either the popliteal or the tibial artery. There was no operative mortality. The mean period of follow-up was 13 months: 18 of the bypasses were patent (2 patients died with open bypass), while 7 bypasses occluded (3 patients died). The authors feel, that isolated artery segment should always be explored. Only an autogenous vein graft should be implanted.
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UNLABELLED: 89 cases of pancreatic or periampullary carcinoma were analysed and the following problems discussed: 1. DIAGNOSIS: "early" diagnosis is at present impossible--not even with E.R.C.P. or angiography, although these provide valuable information for planning the operation. 2. Indication for operation: a curative resection was possible in only 20% of cases. The apparent advantages of total pancreatectomy as against the conventional Whipple operation (increased radicality and reduced post-op. complications) have not yet paid off in terms of improved long-term survival. 3. RESULTS: in 46 pancreato-duodenectomies (for carcinoma as well as complicated chronic pancreatitis) the operative and hospital mortality was 4.3%.
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Benign colonic stenosis may be caused by pancreatitis. Colonic obstruction arising during the acute stage of pancreatitis is mostly found to be reversible. Persistant colonic stenosis after acute or relapsing pancreatitis may point to an adjacent abscess. Two patients with pancreatitic colonic stenosis illustrate those different courses of the disease.