Prevention of clinical acute tubular necrosis with drug therapy.
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Animals↗
Biomedical subjects
M Verbeke
Publications and source records attributed to M Verbeke.
Manual or automatic nulling DC offset for physiological DC amplifier.
An inexpensive circuit to compensate for DC offset is presented. The circuit may be connected in a straightforward manner to any currently existing DC isolation amplifier and causes no deterioration in the performance of the system. The offset voltage is measured at discrete time intervals and then subtracted from the input signal. A switch is provided to bypass the offset compensation when the latter is not required.
Biomedical Engineering↗
Functional analysis of vascular dysfunction in cyclosporin treated rats.
OBJECTIVE: The aim was to analyse vascular damage after chronic cyclosporin treatment (20 mg.kg-1 during 10 d) in rats. METHODS: The reactivity to different vasoactive agents was studied on thoracic aortic rings from control rats, and from rats subjected to renal ablation or cyclosporin treatment. RESULTS: After cyclosporin treatment the endothelium dependent vasodilator responses to acetylcholine and to the endothelium independent NO donors were suppressed. These defects were restored after a 7 d recovery period. The contractile response after inhibition of basal endothelial NO synthesis was unaffected. Further analysis of the blunted vasodilatations not only points to impairments of cGMP mediated mechanisms but shows that other pathways are possibly involved as well. Renal insufficiency induced by renal mass reduction did not influence the aortic reactivity. CONCLUSIONS: Cyclosporin induced vasculotoxicity is a reversible phenomenon, and is not due to renal dysfunction as such. It seems to provoke a defect in the vasodilator mechanisms at the level of the vascular smooth muscle cells and most likely no impairment of endothelial nitric oxide production.
Acetylcholine↗
Computer-controlled portable stimulator for paraplegic patients.
A six-channel lightweight, portable and computer-controlled stimulator for the functional activation of paraplegic patients is described. To enable programming of the various functions, the stimulator was designed to work in a remote-control mode hosted by an IBM PC or compatible computer, in addition to its normally used local mode. The stimulus parameters, including current intensity, stimulus frequency and pulse width, are individually adjustable and programmable for each channel. The power source is 12 V 500 m Ah-1, from 10 rechargeable nickel cadmium batteries, with a run time of 1.5 h for a load of 200 mA in four channels. Various training programmes for the activation of paraplegics in the sitting, standing and walking positions are described. The final design of the stimulator is based on experience gained from 25 patients, treated and evaluated during the course of development. Ongoing work including clinical, biomechanical and physiological studies is carried out to evaluate performance of the activated patients and to optimize stimulation.
Humans↗