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Biomedical subjects

M Yano

Publications and source records attributed to M Yano.

At least 721 records · Page 40Linked to original sources
PubMed1980

Thallium 201 scintigraphy in an infant with myocardial infarction following mucocutaneous lymph node syndrome.

A 4-month-old boy with myocardial infarction following mucocutaneous lymph node syndrome is described.--Angiocardiogram revealed multiple aneurysms of the right and left main coronary arteries, complete occlusion of the left anterior descending and left circumflex coronary arteries, and post-infarction aneurysm of the left ventricle.--Thallium 201 scintigram demonstrated the infarcted area precisely and repeat examinations showed the improvement of the myocardial perfusion, which was probably due to the development of the collateral circulation.

Collateral Circulation↗
PubMed1980

Permeability properties of a multilayer planar membrane.

The permeability properties of multilayer planar membranes of uniformly oriented lipids between a pair of cellulose sheets were investigated. The effect of the two cellulose sheets supporting the lipid membrane on the glucose or the Ca permeation was subtracted empirically, and values of 5 X 10(-6) and 8 X 10(-6) cm/s were thus obtained for the permeability coefficients of an egg yolk lecithin (egg PC)-cholesterol membrane of about 200 bilayers to Ca2+ and glucose, respectively. These values are discussed as compared with the permeability coefficients of other model membranes. The membrane permeability was moderately affected by the addition of chemical substances to egg PC membranes. It was reduced by the presence of cholesterol, but enhanced by the presence of isopropanol, n-butanol, or thymol in the same solution above a critical concentration of each compound. These and previous observations (8) suggest that a close correlation may exist between the permeability of the membrane and the orientation of the membrane lipids. The glucose permeation was drastically suppressed by the presence of Ca2+ (10 mM) in the sample solution with the membrane containing phosphatidylserine, but was not at all suppressed with the membrane of the egg PC-cholesterol mixture.

1-Propanol↗
PubMed1979

Construction of a multilayer planar membrane applicable to ion-transport measurement.

Multilayer planar membranes applicable to ion-transport measurements were constructed from egg yolk lecithin, egg yolk lecithin-cholesterol mixture, and 1,2-dipalmitoyl-sn-glycero-3-phosphocholine between two tightly stretched cellulose sheets. While most of the phospholipids in the membranes were found by a spin label technique to be uniformly oriented with their long hydrocarbon chains perpendicular to the surfaces of the cellulose sheets, a small fraction of phospholipids were isotropically oriented in multilayer membranes. The amount of phospholipids with isotropic orientations decreased with increasing content of cholesterol in membranes and became zero in membranes of egg yolk lecithin-cholesterol mixture (molar ratio of 1: 0.67). The degree of orientation, S, of uniformly oriented phospholipids in membranes was also increased by adding cholesterol to the membranes. The orientation of phospholipids in membranes was rather stable in distilled water and in aqueous calcium chloride (1, 10, 100 mM), while a marked disordering of oriented phospholipids was induced in a aqueous solutions containing thymol, isopropanol, or butanol beyond certain specific concentrations. The membranes can be used for measurements of calcium permeation. An appreciable barrier function to calcium permeation was detected with these multilayer planar membranes as compared with control experiments using only cellulose sheets as membranes. A preliminary investigation suggested that changes in the orientational structure of phospholipids in the multilayer planar membranes are correlated with permeability properties of the membranes.

Biological Transport↗
PubMed1979

Multilayer planar membranes of sarcoplasmic reticulum.

Multilayer planar membranes were constructed between a pair of cellulose sheets from fragmented sarcoplasmic reticulum (FSR) as well as a mixture of egg yolk lecithin and the Ca2+-ATPase purified from FSR. Since sodium deoxycholate was used instead of organic solvents in order to dissolve phospholipids in the process of the membrane preparation, the total activity of the Ca2+-ATPase was still preserved in the planar membrane of FSR. It was also indicated using a spin label technique that the orientation of phospholipids in the planar membrane of FSR was considerably disturbed by the presence of proteins such as the Ca2+-ATPase included in FSR.

Animals↗