Biomedical subjects

Matthieu Pichaud

Publications and source records attributed to Matthieu Pichaud.

2 recordsLinked to original sources

PubMed2005

Protein complexes: structure prediction challenges for the 21st century.

Only a tiny fraction of the many hundreds of known protein complexes are also of known three-dimensional structure. The experimental difficulties surrounding structure determination of complexes make methods that are able to predict structures paramount. The challenge of predicting complex structures is daunting and raises many issues that need to be addressed. To produce the best models, new prediction methods have to somehow combine partial structures with a mixed bag of experimental data, including interactions and low-resolution electron microscopy images.

Binding Sites↗

PubMed2004

A structural perspective on protein-protein interactions.

Structures of macromolecular complexes are necessary for a mechanistic description of biochemical and cellular processes. They can be solved by experimental methods, such as X-ray crystallography, NMR spectroscopy and electron microscopy, as well as by computational protein structure prediction, docking and bioinformatics. Recent advances and applications of these methods emphasize the need for hybrid approaches that combine a variety of data to achieve better efficiency, accuracy, resolution and completeness.

Animals↗