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A structural perspective on protein-protein interactions.

Robert B Russell·Frank Alber·Patrick Aloy·Fred P Davis·Dmitry Korkin·Matthieu Pichaud·Maya Topf·Andrej Sali
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Abstract

Structures of macromolecular complexes are necessary for a mechanistic description of biochemical and cellular processes. They can be solved by experimental methods, such as X-ray crystallography, NMR spectroscopy and electron microscopy, as well as by computational protein structure prediction, docking and bioinformatics. Recent advances and applications of these methods emphasize the need for hybrid approaches that combine a variety of data to achieve better efficiency, accuracy, resolution and completeness.

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AnimalsCrystallography, X-RayHumansMagnetic Resonance SpectroscopyMicroscopy, ElectronModels, MolecularProtein ConformationProtein Interaction MappingProteinsStructural Homology, ProteinTomographyJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, Non-P.H.S.Research Support, U.S. Gov't, P.H.S.Review

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Robert B Russell, Frank Alber, Patrick Aloy, Fred P Davis, Dmitry Korkin, Matthieu Pichaud, Maya Topf, Andrej Sali. 2004. A structural perspective on protein-protein interactions.. https://doi.org/10.1016/j.sbi.2004.04.006

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