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Biomedical subjects

Michael A Friedman

Publications and source records attributed to Michael A Friedman.

11 recordsLinked to original sources
PubMed2006

Empirical comparison of tests for differential expression on time-series microarray experiments.

Methods for identifying differentially expressed genes were compared on time-series microarray data simulated from artificial gene networks. Select methods were further analyzed on existing immune response data of Boldrick et al. (2002, Proc. Natl. Acad. Sci. USA 99, 972-977). Based on the simulations, we recommend the ANOVA variants of Cui and Churchill. Efron and Tibshirani's empirical Bayes Wilcoxon rank sum test is recommended when the background cannot be effectively corrected. Our proposed GSVD-based differential expression method was shown to detect subtle changes. ANOVA combined with GSVD was consistent on background-normalized simulation data. GSVD with empirical Bayes was consistent without background correction. Based on the Boldrick et al. data, ANOVA is best suited to detect changes in temporal data, while GSVD and empirical Bayes effectively detect individual spikes or overall shifts, respectively. For methods tested on simulation data, lowess after background correction improved results. On simulation data without background correction, lowess decreased performance compared to median centering.

Gene Expression Profiling↗
PubMed2005

Is obesity stigmatizing? Body weight, perceived discrimination, and psychological well-being in the United States.

We investigate the frequency and psychological correlates of institutional and interpersonal discrimination reported by underweight, normal weight, overweight, obese I, and obese II/III Americans. Analyses use data from the Midlife Development in the United States study, a national survey of more than 3,000 adults ages 25 to 74 in 1995. Compared to normal weight persons, obese II/III persons (body mass index of 35 or higher) are more likely to report institutional and day-to-day interpersonal discrimination. Among obese II/III persons, professional workers are more likely than nonprofessionals to report employment discrimination and interpersonal mistreatment. Obese II/III persons report lower levels of self-acceptance than normal weight persons, yet this relationship is fully mediated by the perception that one has been discriminated against due to body weight or physical appearance. Our findings offer further support for the pervasive stigma of obesity and the negative implications of stigmatized identities for life chances.

Adult↗
PubMed2005

Predictors of interest in psychological treatment for insomnia among older primary care patients with disturbed sleep.

In this study, we examined whether the common sense model of illness representation (CSMIR) could be successfully used to predict interest in cognitive-behavioral treatment for insomnia (CBT-I) among older primary care patients with disturbed sleep. The Sleep Impairment Index (C. M. Morin, 1993) was used to assess sleep disturbance and the constructs of the CSMIR in primary care patients ages 55 and older. Statistical analyses showed that the CSMIR constructs of consequences (perceived adverse consequences of sleep disturbance to functioning), causes (attributing one's insomnia to bad sleeping habits), and emotion (concern about one's sleep problem) predicted interest in CBT-I. These data provided encouraging support for the ability of the CSMIR to accurately predict patient interest in treatment for insomnia. Implications for assessment and treatment of insomnia in primary care are discussed.

Aged↗
PubMed2004

Discharge criteria for the term newborn.

The birthing process represents a traumatic eviction from the warm, quiet womb with a constant supply of food to the cold, bright world with nothing to eat. Tremendous physiologic strains are suddenly placed on the newborn infant. In a time frame of a few days, the neonate must transition successfully to extrauterine life, and the family must be prepared for the care of their newborn at home. This article reviews the physiologic and social issues that face the newborn and mother, discusses the specific issues created by early discharge, and provides suggested criteria for the timing of discharge of the well term neonate.

Breast Feeding↗
PubMed2004

Does establishing fidelity of treatment help in understanding treatment efficacy? Comment on Bellg et al. (2004).

Comments on the article by Bellg et al (see record 2004-18051-001). To test the effects of a behavioral change on specific health outcomes, the Behavior Change Consortium insists on strict adherence to fidelity at 5 steps in behavioral trials: study design, provider training, treatment delivery, treatment receipt, and enactment of treatment skills. The authors argue that the demand for fidelity at every step ignores 2 critical sets of factors: (a) there are few theoretically grounded empirical studies of the processes involved in successful transitions in this sequence and (b) trials with perfect fidelity absent a theoretical model of transitions will produce evidence for interventions that lack a conceptual basis for adaptation to differences among diseases, treatments, patients, practitioners, medical institutions, and cultures and that therefore cannot be implemented in clinical practice.

Benchmarking↗
PubMed2003

Sociotropy and bulimic symptoms in clinical and nonclinical samples.

OBJECTIVE: The purpose of this study is to examine the relation between sociotropy and bulimic symptoms. Studies of interpersonal functioning among individuals with bulimia nervosa consistently reveal issues of social dependency, need for approval, and fear of rejection. These themes are conceptually related to sociotropy, a cognitive-personality factor that has been implicated in the development and maintenance of depression. Individuals high in sociotropy are keenly invested in attaining others' approval and avoiding social rejection. METHODS: The relationship between sociotropy and bulimic symptoms was examined in two samples of women: undergraduate women and community women seeking treatment at a private eating disorder facility. RESULTS: In both samples, sociotropy was significantly associated with bulimic symptoms beyond the shared relation with depressed mood. DISCUSSION: Findings are discussed in terms of the maintenance and treatment of bulimia nervosa.

Adolescent↗
PubMed2002

Emotional expression and body dissatisfaction.

OBJECTIVE: The purpose of this study was to examine the relation between emotional expression and body dissatisfaction in a sample of young women. METHOD: Participants were 141 female undergraduates. They were assessed for emotional expression, body dissatisfaction, nonassertiveness, and depressive symptoms. The unique relation between emotional expression and body dissatisfaction was analyzed using hierarchical multiple regression. RESULTS: Emotional expression was related inversely to body dissatisfaction. This association was significant after controlling for body mass index, nonassertiveness, and depressive symptoms. DISCUSSION: This is the first study to examine the link between emotional expression and body dissatisfaction. Findings are discussed in terms of possible strategies for modifying shape- and weight-related concerns in women.

Adolescent↗
PubMed2002

Shame and severity of bulimic symptoms.

Initial research suggests that self-conscious affect such as shame may perpetuate bulimic symptoms among individuals suffering from bulimia nervosa (BN). This investigation reports findings from two studies that examine the relation of shame to bulimic symptoms. In the first study, the relation of shame to bulimic symptoms was examined among 137 female college undergraduates. Shame accounted for a significant portion of variance in bulimic symptoms after controlling for age, weight status, guilt, and depressed mood. A second study examined the severity of shame in 30 bulimic patients compared to 28 eating-disordered patients with subclinical symptoms. Although patients with more severe bulimic symptoms exhibited higher levels of shame, this relation was not independent of the shared relation with depression and guilt. Findings are discussed in terms of the role of shame in bulimic symptoms.

Journal Article↗
PubMedDate not supplied

Sexual dysfunction and chronic illness: the role of flexibility in coping.

Sexual dysfunction is common among individuals with chronic illnesses and is associated with distress and reduced quality of life. Because of the long-term, often irreversible nature of sexual dysfunction in chronic illness and limitations of pharmacological treatments, there is a need to understand cognitive and behavioral coping processes in this population. We present a model of coping with sexual dysfunction that focuses on the construct of flexibility, including the definition of sexual functioning and its centrality to overall self-concept. We describe how this model can be applied in a comprehensive approach to treating sexual dysfunction in individuals with chronic illnesses.

Adaptation, Psychological↗