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Biomedical subjects

N A Iudaev

Publications and source records attributed to N A Iudaev.

At least 55 records · Page 3Linked to original sources
PubMedDate not supplied

[Paths of corticosteroid biosynthesis in the adrenal glands of rhesus monkeys].

In experiments in vitro corticosteroid formation from radioactive cholesterol in tha adrenal glands of monkeys (Macaca rhesus) was studied. A conclusion was drawn that pregnenolone and its hydroxy-derivatives were of the leading significance in the cortizol and corticosterone synthesis in the adrenal glands of monkeys. Progesteron was produced in insignificant amounts and was almost unutilized for steroidogenesis. The formation of 17.21-dioxypregnenolone was revealed; its role in the capacity of cortizol precursor was proved; 17-oryprogesteron was found to be of no great significance in cortizol synthesis; 21-oxypregnenolone, but not progesteron proved to serve as the principal intermediate product in corticosterone formation.

17-alpha-Hydroxypregnenolone↗
PubMedDate not supplied

[Sex hormone regulation of progesterone and estradiol receptors in the cytosol of human endometrium in normal and pathologic pregnancy].

Hormonal control of progesterone and estradiol receptors was studied in the cytozol of short-lived culture of human endometrium in normal and undeveloping pregnancy. Endometrium was cultivated in the presence of estradiol or progesterone for 16 hours. In cultivation of normal endometrium with estradiol the content of estradiol receptors increased 4-fold in comparison with unstimulated tissue, and of progesteron receptors--3-fold. In cultivation of normal endometrium with progesterone the content of estradiol receptors rose 4--5-fold, and of progesterone receptors--3-fold. In cultivation of pathological endometrium with estradiol or progesterone the number of estradiol receptors was only doubled, and of progesterone receptors--increased only 1 1/2 times, this pointing to a diminished sensitivity of pathological endometrium to the regulating action of sex hormones.

Cells, Cultured↗