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Biomedical subjects

N A Iudaev

Publications and source records attributed to N A Iudaev.

At least 73 records · Page 4Linked to original sources
PubMedDate not supplied

[Effect of various 1,3,5(10)-estratrien derivatives on the estrogen receptor transport into the nucleus in the guinea pig uterus].

The capacity of five derivates of 1, 3, 5 (10)-estratrien to be transported together with estradiol receptor from the cytoplasm into the nucleus in the uterus of sexually immature guinea pig was investigated. The extent of this transport was assessed by the amount of estrogen receptor in the nucleus following incubation of the uterine slices in the presence of the compound tested (2.5.10(-7) M). The content of estrogen receptor in the nucleus of the intact guinea pig uterus served as control. Incubation of the uterine slices with compounds containing 17 beta-hydroxyl group (2-brom-1, 3, 5 (10)-estratriendiol-3, 17 beta, 4-brom-1,3,5 (10)-estratriendiol, 3, 17 beta, 1, 3, 5 (10)-estratrienol-17 beta), led to a 1.9--4.2-fold increase in the content of nuclear estrogen receptor, this pointing to the transport of the estrogen receptor complex with these compounds into the nucleus. Two compounds (1, 3, 5 (10) estratrienol-3 beta and 3-methoxy-1, 3, 5 (10)-estratrien) contained no 17 beta-hydroxyl group and failed to increase the contents of the estrogen receptor in the nucleus in comparison with control. 17 beta-hydroxyl group is apparently necessary for the formation of conformative changes in the receptor molecule transforming the steroid-receptor complex into the active one, capable of transporting into the nucleus.

Animals↗
PubMedDate not supplied

[Biologically active fragments of protein hormones].

As shown in a number of experiments, corticotropin-like and opiate hormones are synthesized in a body as high molecular protein precursors, involving their biologically-active fragments. Pharmacological properties and perspectives for practical use of somatotropin fragments, synthetic opiate peptides as well as the peptides active in stimulation of pancreatic hormones secretion are considered in details.

Amino Acid Sequence↗
PubMedDate not supplied

[Changes in cyclic nucleotide metabolism in compensatory adrenal hypertrophy (following unilateral adrenalectomy)].

The cyclic nucleotide content, adrenocortical adenylatecyclase, guanylatecyclase, cAMP and cGMP phosphodiesterase activity, as well as the blood corticosteroid content of guinea pigs were determined at the different periods after bilateral adrenalectomy. The raised basal adenylatecyclase effect was also seen during compensatory hypertrophy of the sole adrenal. The response of adenylatecyclase to ACTH and Na is also enhanced at this moment. It is suggested that a physiological increase in the blood ACTH concentration, resultant of unilateral adrenalectomy, intensifies the adenylatecyclase catalytic activity and does not induce enzyme desensitization. The guanylatecyclase activity grows. It was established that changes in both cyclase activities are dependent on the postoperative time and are equal by character. The alteration of adenylatecyclase state always leads to the rise of guanylatecyclase activity. Changes in the cAMP and cGMP phosphodiesterase activity were not observed.

11-Hydroxycorticosteroids↗