Clinicopathologic study of malignant tumors of the large bowel.
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Biomedical subjects
Publications and source records attributed to N Ananthakrishnan.
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A case of giant ureteric calculus 12 cm in length is reported. Only 11 cases of such calculi measuring 12 cm or more have been previously reported in the literature. The relevant features of giant ureteric calculus are discussed.
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Tumoral calcinosis is an interesting clinical entity. It is not uncommon in certain countries. We report our experience with 22 patients with this condition seen over a 7-year period and review in detail the modalities of clinical presentation, theories of etiogenesis, histological appearances, and treatment modalities.
BACKGROUND: Silk and cotton sutures are the most commonly used materials for skin closure, the choice being largely based on tradition. We undertook this study to compare the bacterial adherence in vitro to these two materials because it is well known that the physicochemical characteristics of a suture material influence its ability to attract bacteria and consequently promote wound infection. METHODS: We determined the bacterial adherence in vitro to cotton and silk for Staphylococcus aureus and Escherichia coli, common organisms found in postoperative infection at our institute, using three inoculum strengths. The sutures were incubated with the organisms and bacterial counts per suture material calculated after 20, 60, 120 and 180 hours of incubation. The bacterial counts for the sutures were then compared at these intervals. RESULTS: The bacterial adherence for both organisms at all time intervals was significantly greater to silk than to cotton, except at 60 hours for Staphylococcus aureus. The bacterial count for each suture material appeared to be an intrinsic property of the suture and did not vary with the concentration of the bacteria in the initial inoculum. The cost of an equivalent thickness of silk is 50 times that of cotton. CONCLUSION: We suggest that cotton should be the preferred suture for skin closure because bacterial adherence to it is lower and it is much cheaper than silk.
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Seventy-five gallstones were analyzed layer by layer by x-ray diffraction and microchemical techniques. Microchemical analysis showed that protein was present in 96% of stone nuclei. Application of x-ray diffraction analysis to biliary calculi revealed that cholesterol in three crystalline polymorphs and the three forms of calcium carbonate were the predominant crystalline components. "Cholesterol" and "mixed calculi" revealed differences in their composition. The value of the application of multiphasic qualitative analytical techniques to gallstones is discussed and the pattern of the probable sequence of events in the formation of "mixed" gallstones indicated. It appears that in this process of biliary lithogenesis epitaxy may play a significant role especially in the growth of calculi after formation of the nidus.
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Partial cholecystectomy was performed in this Institute in fifteen patients in the last 8 years. Three were performed in cirrhotic patients with bleeding diathesis. The other indications were obscure anatomy, intraperitoneal adhesions, Mirizzi syndrome and poor general condition of the patient. None of these had any major morbidity in the immediate postoperative period. Partial cholecystectomy is a safe and viable option in a difficult situation.