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Biomedical subjects

N D Selezneva

Publications and source records attributed to N D Selezneva.

At least 37 records · Page 2Linked to original sources
PubMed1995

[Neuroimmune interactions in normal aging and in Alzheimer disease].

The study was undertaken to examine nerve-immune processes and the specific visual and limbic-reticular-cortical systems by analysing visual evoked potentials (VEP), as well as nerve-immune relationships in 21 patients aged 62.2ë1.3 years who had Alzheimer's disease and in 15 healthy individuals of the same age. AD patients were found to have lower lymphocyte count, enhanced proliferative activity of T lymphocytes and to tend to have increased production of interleukin (IL-1) as compared to that in healthy individuals. In AD, latent periods of late EVP components are higher than normal age-specific ones. The relationship between VEP and immunity parameters differ in normal ageing and AD. In health, there is a negative correlation between the latencies of N1, P2, N2 VEP components and the lymphocyte count and between the amplitude of a N1 VEP component and the production of IL-1. There is a prevalent correlation of immune parameters with VEP parameters in the right hemisphere. In AD, the higher proliferative activity of T lymphocytes is associated with more prolonged latent periods of N3 VEP components, suggesting that there are abnormal changes in the limbic-reticular-cortical systems of the brain.

Aging↗
PubMed1994

[The clinico-tomographic correlates in Alzheimer's disease].

Brain computed tomographic scans of 43 patients with Alzheimer's disease (moderate and severe dementia) were compared to those of age-matched normal subjects (30 controls). Computed tomographic analysis included some linear and volume ventricular measurements. These indices correlated with relevant psychopathological and psychometric findings. Linear measurements of the ventricular size and the degree of cortical, central atrophy were significantly greater in patients with Alzheimer's disease than in the control group. In line with the disease progression and its development from moderate to severe dementia the degree of brain structural changes increased with the predominance of cortical atrophy in parietal lobes and central atrophy in mediobasal parts of the temporal lobes.

Aged↗
PubMed1992

[Longitudinal approaches to the problem of clinical heterogeneity of Alzheimer-type dementia].

A total of 160 patients with Alzheimer-type dementias (ATD), including 84 with Alzheimer's diseases (AD) and 76 with senile dementia (SD), were examined. The initial signs of the disease were analyzed by making a retrospective assessment of informative history data. The prospective follow-up involved clinical, neuropsychological and electrophysiological (EEC mapping, evoked potentials) studies by applying the standardized assessment of results. There was shown to be a set of clinical and paraclinical parameters for the status of ATD patients, indicating a distinct-quantitative and qualitative difference between patients with AD and those with SD and supporting the heterogeneity of ATD.

Aged↗
PubMed1992

[EEG-mapping in Alzheimer-type dementias].

EEG topographic correlates of the severity and type of Alzheimer-type dementias have been studied in 21 patients with senile dementia (SD) and 18 with Alzheimer's disease (AD) who were subdivided into smaller groups by MMSE grades for the severity of dementia, as well as in 15 mentally normal elderly persons. EEC maps in SD and AD patients differed from those in normal subjects in increased theta-delta EEG spectral power and suppressed alpha-band power that was more pronounced in the left hemisphere in AD than in SD patients. AD and SD patients had also different EEG topographical changes with intensified cognitive dysfunctions. The results suggest that there is a great cholinergic deficiency and cortical rather than subcortical impairments in patients with AD than in those with SD.

Alzheimer Disease↗
PubMed1990

[Clinical heterogeneity of dementia of the Alzheimer type].

Using clinico-psychopathological, clinico-neuropsychological and computer-aided tomography approaches, material differences were ascertained between groups of patients with Alzheimer's disease (AD) and senile dementia (SD) in terms of the clinical parameters, including the age at which the disease sets in; the disease standing; the build-up features of the patients; the frequency of diverse exogenous and environmental actions at the premorbid stage and at the disease debut; the psychopathological structure of dementia and the initial disease manifestations. The clinical differences indicated were in agreement with different structures of the neuropsychological syndrome marked by the impairment of higher mental functions in AD and SD and with different structures and topography of alterations in the medulla, discovered by means of computer-aided studies. The differences in the clinical and morphofunctional characteristics of AD and SD allow a conclusion that AD and SD are clinically independent disease entities within the framework of the common group of the Alzheimer's type dementias.

Age Factors↗
PubMed1989

[Relation between the changes in evoked and constant potentials of the brain and emotional disorders in Alzheimer's disease].

The visual evoked potentials (VEP), brain DC potential (DP) mapping and emotional disorders were comparatively evaluated in patients with Alzheimer's disease (AD) and age-matched healthy individuals. In AD, the severity of emotional disorders correlated with the reduction of VEP late components P 4 N 4. In patients with frequent affect oscillations, the amplitude of N 3 component of the VEP and its variability was higher than in patients with rare undulations of the emotional state. In AD patients the DP levels were increased as compared to normal levels in all the brain sites investigated. The degree of emotional disorders in AD patients positively correlated with frontal DP levels. The rise in frontal DP levels and decrease in late VEP components were interrelated in AD patients.

Action Potentials↗
PubMed1988

[Comparative age-related clinical characteristics of the initial stage in the course of Alzheimer's disease].

The relation of progressive course of Alzheimer's disease with the age of its onset was established by a retrospective analysis of the psychopathological structure and initial signs of the disease. The overall duration of the disease decreased as the age of its onset increased. This was mainly due to a reduced duration of the initial stage and to a lesser extent to shortening the pronounced dementia stage. Aphasia and apraxia showed different characteristics and rate of occurrence at the initial phase of the ailment. Early initial appearance of motor disorders was characteristic of the disease started before 60. In these cases the distinct cortical functions could be deteriorated in a relatively independent manner. Three major clinical types of the initial stage of the disease are described which correlated with its progression rate and the onset age.

Adult↗
PubMed1986

[Features of the initial manifestations of Alzheimer's disease].

On the basis of a retrospective analysis of characteristics of the initial stage of Alzheimer's disease the authors showed its variability with regard to both clinical manifestations and duration. It was found that the psychopathological structure and increase in disturbances at the initial stage of Alzheimer's disease correlated with the age at the onset of the disease. In some cases an increase in its clinical manifestations could be correlated with definite pretreatment personality peculiarities of the patients. In some patients the cortical focal disorders and intellectual dysfunctions with which dementia first manifested itself became most pronounced in the advanced stage of the pathological process.

Adult↗