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Biomedical subjects

N G Guseva

Publications and source records attributed to N G Guseva.

At least 19 recordsLinked to original sources
PubMed1992

[The clinical significance of detecting the inhibition of topoisomerase I by the sera of patients with systemic scleroderma].

Topoisomerase I activity was studied by electrophoresis in agarose gel according to plasmid DNA relaxation. Sera from 62 patients with systemic scleroderma, 35 with Raynaud's syndrome, 8 with focal scleroderma, 15 with systemic lupus erythematosus, 20 with rheumatoid arthritis and 20 healthy subjects were examined. Out of 62 sera from SSD patients, anti-topoisomerase activity was found in 67.8% of cases. The test appeared positive in 79% of patients with diffuse and 63% with limited disease patterns. The mean age and disease standing were similar in the positive and negative groups. An increase of the skin count and more frequent occurrence of trophic disorders in patients with inhibition of the enzyme were recorded. 40% of the patients demonstrated the coincidence of the results with the use of the topoisomerase test and ELISA. In patients with other rheumatic diseases and in the healthy subjects, no inhibition of the enzyme was found.

Animals↗
PubMed1992

[The use of Capoten in systemic scleroderma].

Experience gained with the use of captopril has been summarized in 5 patients with sclerodermic renal crisis (true sclerodermic kidney) as well as the results of the double blind clinical trial of captopril in 16 patients with Raynaud's syndrome. Captopril given for a long time in the dose 75-150 mg to the patients with true sclerodermic kidney turned out effective which showed up by a decline and stabilization of arterial pressure, decrease of the intensity of azotemia and headaches, and stabilization of renal function. No convincing data have been obtained, that may confirm a beneficial effect of captopril on Raynaud's syndrome. The drug was applied in a dose of 37.5 mg for 2 weeks.

Acute Disease↗
PubMed1991

Markers of collagen and basement membrane metabolism in sera of patients with progressive systemic sclerosis.

The concentrations of the amino terminal propeptide of type III procollagen, the 7S domain of type IV collagen, and the fragment P1 of laminin (PIIINP, 7S, and P1 respectively) and the activity of galactosylhydroxylysyl glucosyltransferase (GGT) in serum were evaluated as indicators of disease activity in a cross sectional study of 84 patients with progressive systemic sclerosis. The mean values of PIIINP, P1, and GGT were raised in progressive systemic sclerosis, 19-32% of patients having abnormal values of the various tests. PIIINP, measured with two different assays, and P1 were associated with active, acute, or subacute disease. GGT also correlated positively with some acute phase proteins in the whole group, without a clear association with the course of the disease. Arthritis was associated with increased PIIINP concentrations as well as with an increased activity of GGT. Kidney disease led to raised concentrations of the degradation products of PIIINP. Raynaud's phenomenon in the hands was related to increased PIIINP concentrations.

Adult↗
PubMed1990

[New markers of collagen and basal membrane metabolism and kidney involvement in systemic scleroderma].

The study was made within the framework of the Soviet-Finnish cooperation and represents a fragment of work pertaining to the clinical trials of new markers of metabolism of collagen and basal membranes in patients afflicted with systemic scleroderma (SSD). Sufficient clinical material (84 SSD patients) and radioimmunoassays were employed to study the clinical significance of aminoterminal propeptide of type III procollagen. In SSD patients with renal impairment (n = 34) and without it, PIIINP and PIIINP-Fab, serum galactosyl hydroxylysylglucosyltransferase and two antigens of basal membranes-7S-domene of type IV collagen and PI-fragment of laminine were determined. Renal impairment was established to correlate with serum concentration of PIIINP-Fab (p less than 0.007). PI-fragment of laminine. The parameters under study correlated as well with the disease course, the presence of arthritis and the Raynaud's syndrome gravity and can be regarded as markers of the disease activity and high fibrous formation lying at the basis of SSD.

Adolescent↗
PubMed1989

[Heterogeneity of the immune response to antigens of the muscular and interstitial connective tissue of the heart in patients with rheumatic diseases. I. Age factors and specificity to alpha-galactose].

Antibodies (Ab) reacting with the myocardial sarcolemma (SL) and interstitial connective tissue (ICT) were determined in 1333 rheumatic disease (RD) patients and in 286 healthy subjects of various age using indirect immunofluorescence technique. The age-related levels of SL and ICT Ab are responsible for the heterogeneous immune response to SL and ICT antigens. The presence of SL Ab is characteristic for young patients, of ICT Ab, for older patients. Children are found to have ICT Ab more infrequently, Sl Ab are more common in rheumatism than in other rheumatic diseases. The higher inflammatory process activity is associated with a more frequent presence of SL Ab and rare ICT Ab in each age group. In RD patients, SL Ab are considered to be risk factor of cardiac disease development. The ICT antigen is found to incorporate alpha-galactose. The reasons for the absence of ICT Ab in the healthy young and in patients with maximum inflammation are discussed.

Adolescent↗
PubMed1989

[A working classification and nomenclature of rheumatic diseases (pediatric aspects)].

The authors provide the working classification of rheumatic diseases prepared by a large group of scientists under the aegis of the All-Union Society of Rheumatologists and under the guidance of V. A. Nasonova, Academician of the USSR AMS. In preparing the final variant of the classification use was made of the experience gained by therapists in cooperation with pediatricians.

Adolescent↗
PubMed1989

[Analysis of the distribution of class I HLA-antigens in patients with systemic scleroderma with regard to features of the clinical course of the disease and therapy with D-penicillamine].

The distribution of HLA-A, B, C antigens has been studied in 40 patients with systemic scleroderma and in 200 healthy individuals (all Russians). An increased frequency of the antigens B35 and Cw4 has been discovered in patients, as compared with control. When analysing different clinical and common parameters, lung affection in the systemic scleroderma patients was found to be associated with the antigen A10 (58.9% versus 21% in control, RR = 5.22, EF = 0.476, Pc = 0.0363), the presence of antinuclear antibodies being associated with the antigen B35 (50% versus 17% in control, RR = 4.8, EF = 0.396, Pc = 0.0354). The association with the antigen B8 most commonly mentioned in the literature was characteristic of the patients with an earlier onset of the disease (under 30 years) and those with the rheumatoid factor. The patients having D-penicillamine-induced complications were found to have an increased frequency of the antigen B8, as compared with the alternative group of patients (2P = 0.0430).

Adolescent↗
PubMed1988

[Sjögren's syndrome in systemic scleroderma].

Combined investigation of 43 patients with sclerodermia systematica (SSD) was conducted to detect Sjogren's syndrome (SS) and to study SSD association with SS. Four groups of patients were defined: with marked SS (10), primary SS (12), probable SS (13), and without SS manifestations (8). Comparative characterization has shown that SS is detected slightly more frequently in a chronic course of SSD, combines with manifestations of sclerodactyly, telangiectasia, calcinosis, however esophageal hypomobility, indurative skin changes and contractures which are typical of SSD, occur less frequently than in SSD patients without SS. SSD association with SS is characterized by polyarthralgia, arthritis, marked Raynaud's syndrome, the frequency and rather high RF titers, the detection of anti-Ro and anti-La, and a significant rise of the level of circulating immune complexes determined by SS influence. SS manifestations in SSD are retention pains in the parotid glands, signs of clearness on sialograms, periductal sclerosis in the form of rings in morphological investigation of the parotid glands.

Adult↗
PubMed1987

[Treatment of Raynaud's syndrome with calcium entry blockers].

The authors have presented the results of a 14-day open randomized trial of the efficacy of 3 calcium inlet blocking agents: nifedipine, verapamil and phendilin in 61 patients with Raynaud's syndrome. In the group of patients receiving 30-80 mg of nifedipine (20) there was a significant decrease in the frequency and expression of Raynaud's syndrome attacks, a positive effect of varying degree was noted in 19 patients. The drug raised slightly the skin and muscular blood flow and skin temperature. The use of 120-360 mg of verapamil in 21 patients caused no significant inhibition of Raynaud's syndrome and rise of hemocirculation. Phendilin (150-300 mg) though being comparable with nifedipine in efficacy, often produced side-effects resulting in the drug cancellation (8 out of 20). The efficacy of the calcium inlet blocking agents, especially nifedipine, for therapy of Raynaud's syndrome was emphasized.

Adolescent↗
PubMed1987

[The sclerodermatous group of diseases].

The paper is concerned with the author's considerations on a sclerodermic group of diseases including a wide spectrum of diseases with systemic or local "primary" fibrosis on the basis of the results of her own investigations and the literature data. Multifactorial genesis of diseases, cellular mechanisms and the interrelationship of fibrosis with immune and microcirculatory disturbances are discussed with regard to sclerodermia systematic. Recently defined, hitherto unknown diseases and syndromes were described: diffuse eosinophilic fasciitis, the paraneoplastic sclerodermic syndrome "induced" sclerodermia, local fibroses. An analysis of the sclerodermic group of diseases and the chief mechanisms of their development is important for improved diagnosis and development of effective programs of pathogenetic therapy, prevention and mass screening.

Adult↗