PubMed Health⌕ Search

Biomedical subjects

N G Guseva

Publications and source records attributed to N G Guseva.

At least 37 records · Page 2Linked to original sources
PubMed1997

[The evolution of juvenile systemic scleroderma].

60 cases of scleroderma systematica with onset in the childhood or adolescence have been analyzed. Juvenile scleroderma took, as a rule, a favourable course (78%). Slow progression was observed in 43% of patients. Stabilization occurred in 20% of cases. A complete regression was seen in 15%. The disease ran unfavorably in 5% of the cases. Overlap-syndrome occupied an intermediate position between favourable and unfavourable disease. It was registered in 17% of cases. The prognosis is better in early detection of the symptoms and choice of adequate therapy.

Adolescent↗
PubMed1996

[Myocardial tomoscintigraphy with 201Tl in the diagnosis of cardiac involvement in systemic scleroderma].

Myocardial microcirculation was assessed in 23 scleroderma systematica patients using 201Tl tomoscintigraphy at rest (23 patients) and upon dipyridamole vasodilation (6 patients). Most patients were found to have impaired blood supply of the myocardium with sites of myocardiofibrosis. In response to dipyridamole introduction improved myocardial perfusion was registered in 4 out of 6 patients, 1 patient showed signs of transient myocardial ischemia, 1 patient had stable defects of myocardial blood supply. It is suggested that some sclerodermic patients may benefit from vasodilators.

Adult↗
PubMed1995

[Antiendothelial antibodies in systemic scleroderma and Raynaud's disease].

Using ELISA on fixed endothelial hybridoma (EAhy.926) cells we investigated the occurrence of antiendothelial antibodies (AEA) in the sera from patients with scleroderma systematica (SS) (n = 70) and Raynaud's disease (RD) (n = 19). The mean IgG and IgA-AEA levels were significantly higher in the SS patients than RD patients (p < 0.001) and controls (p < 0.001). We have detected circulating IgG-AEA in 64.2% of patients with SS, 35.2% of SS sera were positive for IgA-AEA. In patients with RD, the frequency of AEA corresponded to that of the random population sample. We have found a high incidence of Raynaud's phenomenon, myositis, telangiectasia and marked digital ischaemia (digital ischemic pulp ulcers, digital scars, osteolysis and autoamputation) among AEA positive patients with SS. AEA-positive patients were characterized by high extent and severity of Raynaud's phenomenon and higher average nailfold capillary microscopy scores. No correlations were found between AEA and different clinical or laboratory parameters, including the type of scleroderma (diffuse and limited), the presence of anti-Scl-7O and anticentromere antibodies and the clinical features of SS (lungs, kidneys and heart involvement, esophageal dysfunction, calcinosis, Sjogren's syndrome). There was no significant correlation between the AEA level and patient age, extent of skin involvement (skin score). Thus, in SS, AEA is associated with a peripheral vasculopathy and represent a useful marker for the diagnosis of endothelial dysfunction.

Adolescent↗
PubMed1995

[Myocardial scintigraphy with thallium-201 in the diagnosis of cardiac involvement in systemic scleroderma].

201Tl scintigraphy of the myocardium is a highly sensitive method of diagnosis of cardiac damage in SS. More severe lesions occur in patients with diffuse skin affections and subacute SS. Improvement of perfusion in dipiridamol test indicates the contribution of the spasm of microcirculation coronary vessels to the onset of perfusion defects. Further investigations are needed for evaluation of the role various vasodilators have in prevention of perfusion lesions and progressive myocardial fibrosis in SS patients.

Adult↗
PubMed1995

[The assessment of left ventricular diastolic function in patients with systemic scleroderma by radionuclide ventriculography].

To assess left ventricular (LV) diastolic function in scleroderma systematica (SS) with regard to SS course and skin lesion degree, a total of 24 SS patients were examined versus control subjects. Though cardiac symptoms manifested clinically only in 8 patients, parameters of LV diastolic function underwent changes in the majority of the examinees: the time to attaining maximal filling velocity increased, contribution of the first diastolic third to LV filling diminished, hemodynamic significance of the left atrial systole grew. More pronounced dysfunction of the myocardium occurred in patients with diffuse skin lesions, acute and subacute disease who also appeared to have reduced LV ejection fraction. The conclusion is made on frequent subclinical pattern of myocardial involvement in SS patients which runs primarily as LV diastolic dysfunction. Systolic disturbance emerge later or in more active forms.

Acute Disease↗
PubMed1994

[Tramadol in the vascular pains of patients with systemic scleroderma and other rheumatic diseases].

A study was made of the effect of tramadol on vascular pains in 20 patients with systemic scleroderma and other rheumatic diseases, using a visual analogue scale. In eleven patients, ischemic and ulceronecrotic lesions were at the basis of the painful syndrome. In this case the pains were most severe. In five patients, the lesions were of vascular and neuromuscular character. 50% of the patients demonstrated a good effect, 35% a satisfactory one, and 10% had a complete analgesia. Tramadol was administered in a daily dose of 100 to 200 mg, mainly per os. It is recommended that tramadol may be used in patients with the painful syndrome of vascular genesis.

Adolescent↗
PubMed1993

[The role of sympathetic reactivity in the development of Raynaud's syndrome].

Finger skin blood flow was studied in 131 patients with Raynaud's syndrome using laser Doppler flowmetry. Scleroderma systematica, systemic lupus erythematosus, rheumatoid arthritis, Sjogren's disease, mixed connective tissue lesions, Raynaud's disease were diagnosed in 61, 17, 10, 10, 10 and 13 examinees, respectively. Control consisted of 20 healthy subjects. The response of the blood flow was registered in response to functional tests activating sympathetic nervous system: indirect cooling, emotional stress, deep inhalation, Valsalva's test. Hyper-response to the above sympathetic stimulation was noted in none of the groups studied. In scleroderma systematica the reactivity significantly decreased with longer disease duration. It is clear that the study did not confirm the leading role of sympathetic hyperactivity in Raynaud's syndrome pathogenesis.

Adolescent↗
PubMed1992

[The clinical significance of detecting the inhibition of topoisomerase I by the sera of patients with systemic scleroderma].

Topoisomerase I activity was studied by electrophoresis in agarose gel according to plasmid DNA relaxation. Sera from 62 patients with systemic scleroderma, 35 with Raynaud's syndrome, 8 with focal scleroderma, 15 with systemic lupus erythematosus, 20 with rheumatoid arthritis and 20 healthy subjects were examined. Out of 62 sera from SSD patients, anti-topoisomerase activity was found in 67.8% of cases. The test appeared positive in 79% of patients with diffuse and 63% with limited disease patterns. The mean age and disease standing were similar in the positive and negative groups. An increase of the skin count and more frequent occurrence of trophic disorders in patients with inhibition of the enzyme were recorded. 40% of the patients demonstrated the coincidence of the results with the use of the topoisomerase test and ELISA. In patients with other rheumatic diseases and in the healthy subjects, no inhibition of the enzyme was found.

Animals↗
PubMed1992

[The use of Capoten in systemic scleroderma].

Experience gained with the use of captopril has been summarized in 5 patients with sclerodermic renal crisis (true sclerodermic kidney) as well as the results of the double blind clinical trial of captopril in 16 patients with Raynaud's syndrome. Captopril given for a long time in the dose 75-150 mg to the patients with true sclerodermic kidney turned out effective which showed up by a decline and stabilization of arterial pressure, decrease of the intensity of azotemia and headaches, and stabilization of renal function. No convincing data have been obtained, that may confirm a beneficial effect of captopril on Raynaud's syndrome. The drug was applied in a dose of 37.5 mg for 2 weeks.

Acute Disease↗
PubMed1991

Markers of collagen and basement membrane metabolism in sera of patients with progressive systemic sclerosis.

The concentrations of the amino terminal propeptide of type III procollagen, the 7S domain of type IV collagen, and the fragment P1 of laminin (PIIINP, 7S, and P1 respectively) and the activity of galactosylhydroxylysyl glucosyltransferase (GGT) in serum were evaluated as indicators of disease activity in a cross sectional study of 84 patients with progressive systemic sclerosis. The mean values of PIIINP, P1, and GGT were raised in progressive systemic sclerosis, 19-32% of patients having abnormal values of the various tests. PIIINP, measured with two different assays, and P1 were associated with active, acute, or subacute disease. GGT also correlated positively with some acute phase proteins in the whole group, without a clear association with the course of the disease. Arthritis was associated with increased PIIINP concentrations as well as with an increased activity of GGT. Kidney disease led to raised concentrations of the degradation products of PIIINP. Raynaud's phenomenon in the hands was related to increased PIIINP concentrations.

Adult↗