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Biomedical subjects

N I Bubnova

Publications and source records attributed to N I Bubnova.

At least 19 recordsLinked to original sources
PubMed1991

[Morphogenesis of bronchiectasis in children of preschool age].

Surgical material from 24 children aged 2-6.5 years was investigated for studying morphological features and morphogenesis of bronchiectatic disease (BED) associated with lung immaturity. Leading role in the development of BED belongs to the deficiency of the lung defense at the time of the disease onset and premorbid background. Purulent-destructive alterations of the lung are the basis of grave persistent recurring BED.

Bronchiectasis↗
PubMed1990

[Artificial late abortion for medical genetic indications].

Late abortions have been induced for genetic indications in 96 women using intra-amniotic administration of 20% sodium chloride or Enzaprost. The results were compared within this group and with a control group of 90 women whose pregnancies were terminated for other indications at similar dates and with the same agents. The use of 20% sodium chloride was associated with significantly higher blood loss and greater lengths of abortions. Patterns and rates of complications were comparable in both groups. These data suggest a utility of 20% sodium chloride and, especially Enzaprost, in late pregnancy termination for genetic indications.

Abortion, Eugenic↗
PubMed1990

[The pathogenesis and morphogenesis of noninflammatory lung diseases in premature infants].

Studies of the morphofunctional status of the lungs in premature infants showed that the factors responsible for the immaturity of the bronchoalveolar tissue played a major role in the patho- and morphogenesis of noninflammatory conditions: atelectasis and hyaline membrane disease. Of special significance is inadequate differentiation of the alveolar parenchyma and blood-air barrier as well as the presence of large amounts of serotonin-containing APUD cells in the immature lungs. When released into the surrounding parenchyma under the influence of pathogenic factors, serotonin brings about the development of broncho- and vasoconstriction, microthrombosis, and increased permeability of the vascular walls, which induces the development of hyaline membrane disease in premature infants. The findings open up new possibilities for the elaboration of new prevention and therapy patterns in combating this condition.

Humans↗
PubMed1989

[Value of echoencephalography in the diagnosis of periventricular leukomalacia in children and the prognosis of their development].

The investigation was conducted to reveal reliable echographic features of early (necrotic) stages of periventricular leukomalacia (PVL) on the basis of retrospective analysis of echograms of decreased children (with postmortem diagnosis of PVL) and survived newborns with pronounced cystic changes in the periventricular areas (advanced PVL stage), which were revealed during dynamic echoencephalography. Altogether 268 echograms of 78 children with a birth-weight from 700 to 2400 g were analysed. All children but one were born preterm. Ultrasound device "Aloka-SSD 118" (Japan), with a transducer frequency of 5mHz, was used during frontal fontanel echoencephalography. Three patterns of echographic image of periventricular areas compromised with the aforementioned disease were identified. In the detection of early PVL stages, the specificity of the technique was 94% and sensitivity, 86%. The followup that lasted from 9 months to 2.5 years revealed varying pronounced neurologic disorders in all the survived children with PVL.

Brain↗
PubMed1987

[Morphofunctional state of the APUD-system cells of the lungs in hyaline membrane disease of newborn infants].

Examination of these cells in newborn infants with hyaline membrane disease. (HMD) has demonstrated involvement of neuroendocrine elements in its patho- and morphogenesis. A crucial factor in HMD development is immaturity of the lungs, one sign of which is the presence of numerous serotonin-containing cells. Degranulation of APUD cells and serotonin lease under exposure to pathogenic factors initiate pathologic reactions in the lungs and account for the earliest manifestations of the disease.

APUD Cells↗
PubMed1986

[Marfan's disease in a pregnant woman and her fetus].

An observation of Marfan's disease occurring simultaneously in mother and her fetus is described indicating an intrauterine formation of the alterations specific for this disease. Specific for Marfan's disease changes in the fetal aorta are shown. The problem of the influence of pregnancy on the course and outcome of Marfan's disease is discussed.

Adult↗
PubMed1982

[Partial trisomy 13 for the distal long arm and its prenatal diagnosis].

The results of prenatal diagnosis of fetal karyotype in a woman carrier of reciprocal t(13; 21) (q22; q22) translocation during her second pregnancy are presented. The first pregnancy ended in a term delivery of male twins with multiple malformations typical of the Patau syndrome. No cytogenetic investigation was carried out in this case. In the second pregnancy, unbalanced fetal 46,XX,21q+ karyotype was determined in amniotic cell cultures. The pregnancy was terminated after 19 weeks using intraamniotic PgF2 alpha. Phenotypical and pathoanatomical description of the aborted embryo presented corresponds to the clinical picture of the Patau syndrome. The 46,XX,21q+ karyotype was confirmed in fetal skin fibroblast cultures (skin biopsy specimens obtained during induced abortion), namely, partial trisomy for the distal part of the long arm (13q22) of chromosome 13 translocated to chromosome 21, as a result of inherited unbalanced variant of maternal translocation, was demonstrated. Comparative data on phenotype/karyotype correlation of individuals with partial trisomy 13 for distal part of the long aem of varying length are discussed.

Abnormalities, Multiple↗