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Biomedical subjects

N I Fadeeva

Publications and source records attributed to N I Fadeeva.

43 records · Page 3Linked to original sources
PubMedDate not supplied

[Influenza virus replication in the presence of bonafton and other inhibitors of macromolecular synthesis].

Formation of virus-specific RNAs in the presence of bonafton, actinomycin D, and cycloheximide was studied. The degree of bonafton inhibition of the synthesis of the genome and complementary RNAs in the nucleus and cytoplasm of the infected cells varied. The effect of bonafton on replication and transcription of influenza virus differs from that of actinomycin and cycloheximide. Bonafton appears to disturb the regulation of these processes, specifically inhibiting the synthesis of individual fragments of viral RNA.

Animals↗
PubMedDate not supplied

[Immunostimulating effects in the body induced by bonafton].

Study of the primary immune response in CBA mice which were injected with bonafton (1.5-3 mg/kg i.p.) for 3 days has revealed stimulation of antibody formation. The maximal effect as regards the humoral immune response has been recorded on the drug use in a dose of 2 mg/kg. It has been discovered that bonafton (1-3 mg/kg) also activated the cell immune response--delayed type hypersensitivity.

Adjuvants, Immunologic↗
PubMedDate not supplied

[Effect of dioxidine on DNA and RNA synthesis in Staphylococcus aureus].

The effect of dioxidin on DNA and RNA synthesis by Staphylococcus aureus was studied with the use of labeled precursors and evaluated from the kinetics of DNA and RNA accumulation by the culture. It was shown that dioxidin inhibits DNA synthesis by Staphylococcus aureus cells, with the synthesis of RNA being almost not affected. The main effect manifests within the first hour of the drug interplay with the microbial cell, it is reversible and appears to be realized by the mechanisms of DNA synthesis regulation. Dioxidin does not form complexes or cross-linkages with the DNA molecule. The action of dioxidin on the microbial cell manifests in the derangement of the activity and biosynthesis of extracellular DNase.

Anti-Bacterial Agents↗
PubMedDate not supplied

[Study of the effect of dioxidine on the subcellular fractions of microbial cells].

Penetration of dioxidine to the cells of Staphylococcus aureus and the drug effect on subcellular fractions were examined. High pressure liquid chromatography demonstrated that after penetration to the cells of Staphylococcus aureus dioxidine was found unchanged in the cytoplasmic fraction. Differences were disclosed in the biochemical action pattern of the drug on the growing and stationary culture. Exposure of the growing culture to dioxidine resulted in an appreciable decrease in the protein and especially in nucleic acid levels, in significant changes in the composition of the intracellular protein complex. The drug produced structural alterations within the cell wall. These alterations increased with concentrations and were characterized by the loosening of the wall and by the membrane release.

Bacterial Proteins↗
PubMedDate not supplied

[Effect of quinolaline di-N-oxide derivatives on the DNAse and plasmocoagulase of Staphylococcus aureus].

The effect of the di-N-oxide quinoxaline on the activity and biosynthesis of DNA-ase and plasmocoagulating properties of the Staphylococcus aureus, strain Zhaev, was studied. The highest action in respect to DNA-ase of the Staphylococcus is shown to display dioxydine (1,4-di-N-oxide of 2,3-dioxymethylquinoxaline). Under its effect there takes place a significant fall of the DNA-ase activity and the plasmocoagulating properties of the staphylococcus. In cultures treated with dioxydine or its biologically active analogues the ability to biosynthetize DNA-ase with subsequent cultivationon on a medium containing no compounds is not restored. A possible mechanism of action produced by the study drugs is suggested.

Coagulase↗