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Biomedical subjects

N I Kolycheva

Publications and source records attributed to N I Kolycheva.

At least 19 recordsLinked to original sources
PubMed1992

[Adenogenous cancer of the esophagus].

Bioptates and resected material from patients treated for cancer of the esophagus at the Kazakh Research Institute of Oncology in 1980-1989 were analysed. Adenogenic tumors made up 6.0% of the 1671 cases of esophageal cancer studied. A gradual increase in the percentage of adenogenic cancers was established (P < 0.05). A group of 100 cases of adenogenic cancers was examined in detail. Adenocarcinoma made up 5.3%, adenosquamous cancer--0.5 and adenocystic cancer--0.2%. Adenogenic cancers most often occurred in the lower thoracic part of the organ. Poorly differentiated adenocarcinoma predominated (56.8%), with a tendency to an increase in the tumor occurrence in the upper and mid-thoracic parts. The enhanced morbidity from adenogenic cancers is attributed to a high occurrence of esophagitis in the majority of regions of Kazakhstan.

Adenocarcinoma↗
PubMed1990

[Polycystosis of the esophagus].

A rare observation in a male patient of 72 suffering from pulmonary tuberculosis. Severe chronic oesophagitis complicated with polycystosis was found at the autopsy. Multiple retention cysts up to 0.5 cm in diameter were formed due to the obturation of excretory ducts. The disease was not diagnosed clinically.

Aged↗
PubMed1988

[Electron microscopic study of the histogenesis of dimorphous adenosquamous cell cancer of the esophagus].

The report discusses a comparison of the results of electron microscopic study of glandular-squamous cell carcinoma of the esophagus, normal mucous gland tissues of the same organ and those in reserve cell proliferation. Glandular-squamous cell cancer tissues were found to contain tumor squamous-epithelial cells, glandular cells with secretory grains inherent in the mucous glands proper of the esophagus as well as chimera cells revealing the ultrastructural characteristics of the two cellular type. Further support was obtained for the previously suggested view on the bipotent epithelium of ducts of the mucous glands proper as a source of glandular-squamous cell carcinoma of the esophagus.

Adenocarcinoma↗
PubMed1988

[Electron microscopic verification of adenocarcinoma of the cardioesophageal area].

Normal gastric and esophageal cardiac glands as well as proper esophageal glands were studied electron-microscopically. Cardiac gastric and esophageal glands were found to differ by chief cells available in the gastric glands and greater amounts of endocrine cells registered in the esophageal glands. The evidence can provide grounds for electron microscopic verification of cardioesophageal adenocarcinoma permitting the pathologist to rest upon the presence of cells resembling those of proper gastric glands and epigastric fossa. In addition, it can promote specification of the morphologic type of adenogenic esophageal cancer comprising squamous epithelial component and secretory granules typical of proper esophageal glands.

Adenocarcinoma↗
PubMed1987

Method of separate bronchospirography with the use of bronchofibroscope and its clinical value in lung cancer patients.

In this paper the authors describe: a method of bronchospirography with the use of bronchofibroscope; a method of simultaneous performance of bronchospirography and bronchofibroscopy; criteria of indices and staging of each lung ventilation capacity; patterns of interrelation of the "healthy" and disabled lung according to the degrees of lung ventilation disturbance; indications and contraindications to operative treatment based on bronchospirographic data. For evaluation of the operability bronchospirographic investigations of the lung ventilation capacity were carried out in 225 lung cancer patients.

Adult↗
PubMed1987

[Prognostic value of ultrastructural characteristics of dysplastic changes in the esophagus].

Dysplasia foci in the esophageal squamous epithelium against the background of various reactions of proliferation were studied by electron microscopy. Slightly altered tissue showed diverse cellularity, with dark cambial elements invariably present. With dysplasia advancing, the cell composition became uniform, with a high nuclear-cytoplasmic index. The dark cell pattern with numerous ribosomes was seen more often than that of keratinized clear cells. Small-cell focal proliferations are highly suggestive of precancer. Electron microscopy may be instrumental in eliciting more information on the risk of esophageal squamous epithelium precancer progressing to cancer since it provides data on cell composition, degree of cell differentiation and polysome formation as well as early signs of keratinization.

Burns, Chemical↗
PubMed1986

[Clinical prevention of esophageal cancer].

An effective method of complex treatment of reflux-esophagitis with reparation stimulants (methyluracil) was developed to improve clinical prophylaxis of esophageal cancer. Application of the said method was followed by a 3-5-fold increase in "clinical recovery" rate, slower advancement of pathologic changes in the esophageal epithelium thus lowering the risk of neoplasia. Within 5 years of dynamic follow-up, patients with esophagitis exposed to the above treatment showed a 4-fold decrease in risk for cancer. A special program of screening for esophagitis, its treatment and patients' follow-up is discussed.

Combined Modality Therapy↗
PubMed1986

[Vascularization--a prognostic indicator of radiation sensitivity of laryngeal cancer].

Vascularization of laryngeal tumors in 79 patients was determined using a specially devised method. According to the quantity of capillaries in a visual field 3 degrees of vascularization were singled out. A close correlation between the vascularization of tumors and their radiocurability was revealed. In poorly vascularized tumors the local regression and 5-year survival were significantly lower than those in richly vascularized tumors.

Capillaries↗
PubMed1985

[Ultrastructure of squamous epithelium in esophageal dysplasia and squamous cell cancer].

Electron microscopic examination of the oesophageal squamous cell carcinoma revealed the presence in the tumour of both undifferentiated and differentiated squamous cells. Keratinocytes appeared and the signs of keratinization were more pronounced in the cytoplasm of differentiated cells. Dysplastic changes were observed at the periphery of the primary node. Two main variants of dysplasia (dark-cell and clear-cell) were distinguished, this at the ultrastructural level being the reflection of the direction of differentiation and the degree of cell maturity in the dysplastic foci. With the exception of few cases with a cell polymorphism in the foci of a severe dysplasia, dysplastic changes of the squamous epithelium were characterized by a monotonous ultrastructural cell composition. The dysplastic cells were distinguished by a degree of differentiation and high synthetic activity.

Carcinoma, Squamous Cell↗
PubMed1984

[Morphological variants of glandulo-squamous cell cancer of the esophagus].

Microscopical examination of glandular-squamous cell carcinoma of the esophagus (20 cases) showed the variability of its structure. The following morphological varieties of the glandular tumour component are established: tubular, papillary, cystic, mixed. The degree of the tumour component differentiation can vary and this should be reflected in the histological diagnosis. The ultrastructural features characteristic of squamous and glandular epithelium are identified by electron microscopy.

Adenocarcinoma↗
PubMed1983

[Ultrastructure of the esophageal mucus glands in normal conditions and in esophageal cancer].

The ultrastructure of the glandular apparatus and epithelium of the excretory ducts of esophageal mucous glands proper normally and in esophageal carcinoma was studied electron microscopically. Acinar cells were represented by two kinds, "Dark" and "clear" cells reflecting alternating activity of the secretory cells. The ultrastructural features of the reserve cells of excretory ducts such as hypertrophy of the nucleus, scalloped nuclear membrane, high electron density of the nucleus and cytoplasm, abundance of ribosomes and polysomes allow them to be considered as low differentiated highly active cambial elements. In esophageal carcinoma, reserve cell proliferates of the excretory ducts were found to have granule-containing cells possibly related to the system of serotoninocytes. The reserve cells showed ultrastructural changes with signs of dysplasia.

Adenocarcinoma↗
PubMed1982

[Esophageal and stomach pathology of residents in areas characterized by a high incidence of esophageal cancer morbidity].

A high incidence of pathology in the esophagus was established in patients with chronic, particularly atrophic, gastritis (esophagitis, leukoplakia, dysplasia, fibrosis of submucosa, early forms of cancer, etc.). Most patients with chronic gastritis revealed esophagitis (71%) with concomitant leukoplakia (70.6%) or dysplasia (49%) which can be identified as precancer. Therefore, patients suffering from severe chronic gastritis, involving lesions of glands and atrophy of mucosa, living in areas with highly-endemic esophageal cancer should be referred to those at high risk for cancer of the esophagus. Timely examination for and therapy of chronic esophagitis in patients with a long history of severe chronic gastritis should be indispensable to prevent esophageal cancer.

Adult↗
PubMed1982

[Ultrastructure of esophageal epithelium under normal conditions and in dysplastic foci].

Electron microscopic examinations of the ultrastructure of normal esophageal epithelium of an adult man revealed submicroscopic features of each epithelial layer. A specific structure of epithelial cells is represented by tonofibrils. Glycogen is found only in the prickle-cell and superficial layers. In the latter there were some signs of incomplete keratinization. Hyperplasia of the prickle-cell and superficial layers epithelium was accompanied by accumulation of glycogen and marked parakeratosis with disintegration of the nucleus, formation of keratin fibrils, and destruction of desmosomal bonds. Dysplastic changes in the esophageal epithelium were heterogenous and presented a whole set of ultrastructural rearrangements. We distinguish two variants of dysplasia. In the "dark-cell" variant there were hypertrophy and hyperchromia of the nucleus, deep invaginations of the nuclear membrane, swelling of the mitochondria, appearance of myelin-like structures in the matrix, increased number of free ribosomes, polysomes, and lipids, formation of tonofibrillar-keratohyaline complexes, increased number of cytoplasmic processes. The "clear-cell" variant was characterized by nuclear hypertrophy, marked dilation of cisterns of the rough endoplasmic reticulum, extensive vesicle formation, keratohyaline granules, few cytoplasmic outgrowths, dilation of the intercellular space.

Adult↗
PubMed1981

[Esophagitis in alcoholics].

Morphological examinations of esophaguses of 65 subjects who had suffered from alcoholism revealed a high rate of inflammatory lesions in the esophagus and epithelial leukoplakias and dysplasias developing against this background. It is suggested that the regular use of alcohol may be classified among the factors predisposing to the development of esophageal precancer and cancer.

Adult↗