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N I Shapiro

Publications and source records attributed to N I Shapiro.

At least 91 records · Page 5Linked to original sources
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[Delayed-type hypersensitivity reaction induced in mice by the administration of an inactivated influenza vaccine].

The conditions of delayed-type hypersensitivity induction following immunization with an inactivated influenza vaccine in BALB/c and CBA/H mice treated with cyclophosphane were studied. The results showed that the delayed-type hypersensitivity reaction had no type specificity when revealing preparation injected to immunized mice is a vaccine prepared with chorioallantoic fluid, but it is specific when a tissue vaccine is used. The use of inactivated influenza viruses cultivated on different cell-types for sensitization and revelation of the hypersensitivity state allowed to evaluate the level of the delayed-type hypersensitivity induced by untreated virus.

Animals↗
PubMedDate not supplied

[Adsorbed subunit influenza vaccine: its isolation and characteristics].

Experimental batches of adsorbed subunit influenza vaccine were prepared from the envelope of glycoprotein antigens separated from the influenza virion by treatment with a cationic detergent (cetyltrimethylammonium bromide). Purified and concentrated influenza virus strains A(H1N1) and A(H3N2) were obtained by gradient centrifugation; additional purification, with a view to removing ovalbumin and structural components of the chorioallantoic membrane, was achieved by gelfiltration. The composition and biological properties of the vaccine are described.

Adsorption↗