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N I Shapiro

Publications and source records attributed to N I Shapiro.

97 records · Page 6Linked to original sources
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[Immunization with a complex preparation: a new method of influenza prevention. The basis for using a complex preparation for preventing influenza].

A combined preparation for influenza prevention (CPIP) consisting of an interferon inducer stimulating immunogenesis and killed influenza vaccine is proposed. Twenty five inducers-stimulators have been tested: polynucleotides, polysaccharide and lipopolysaccharide extracted from Salmonella typhosa. Intranasal administration of CPIP to laboratory animals markedly stimulates interferon, secretory, and circulating antibody synthesis. Resistance to fatal influenza infection develops within 18 hours after administration of CPIP and its intensity increases in the following 14 days (the observation period.

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[Effect of endotoxin on the migration of hematopoietic colony-forming cells and on the repopulation of hematopoietic organs in partially irradiated mice].

In experiments on (CBA X C57BL)F1 hybrids it was shown that the administration of sublethal doses of endotoxin to locally exposed (spleen, 9 Gy) animals enhanced the repopulation of the exposed haemopoietic tissue (spleen and bone marrow). It is concluded that endotoxin has a favourable action on the recovery of haemopoiesis of partially irradiated mice which confirms the idea of the possibility of using stimulators instead of autotransplantation of bone marrow from intact parts.

Animals↗