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Biomedical subjects

N Kutlu

Publications and source records attributed to N Kutlu.

At least 19 recordsLinked to original sources
PubMed2004

Differences in the cellular and humoral immune system between middle-aged men with different intensity and duration of physically training.

AIM: The effects of acute exercise on immune system and serum magnesium and iron have been investigated in recent years. However, data related to the comparisons of long-term physical training with different intensity and duration are limited. METHODS: The association between long-term physical training and cellular (lymphocyte phenotyping) and humoral immune parameters (serum immunoglobulins) and serum magnesium and iron values in the middle-aged men was investigated. Eleven male master athletes (MA) performing high intensity and long duration training, 11 male recreational athletes (RA) performing moderate intensity and duration training (>10 years) participated. Eleven male sedentary individuals were enrolled as control group (CG). RESULTS: The percentages of total CD3+ T cells, CD4+ T helper, CD8+ T suppressor/cytotoxic, CD19+ B cells, natural killer cells, HLA-DR+ active T cells and CD4/CD8 ratios did not show any significant difference among 3 groups. In MA, VO2max values showed a significant negative correlation with CD4+ T helper cells. There were no significant differences among MA, RA and CG in terms of IgG, IgA, and IgM concentrations. There was a significant correlation between VO2max and IgG in RA. Iron, iron binding capacity and ferritin were found similar in all groups, but serum magnesium level in MA was significantly lower than RA and CG. CONCLUSION: No exact data to support immunosuppression or immunostimulation could be obtained except a significant negative correlation between CD4+ T helper cells and VO2max values in MA and a positive correlation between serum IgG and VO2max ivalues in RA. These findings may be the indirect markers of cellular immune system suppression by intensive exercises and stimulation of IgG production by moderate exercises.

Case-Control Studies↗
PubMed2001

Testosterone and nonverbal intelligence in right-handed men with successful and unsuccessful educational levels.

The relationship between serum total testosterone (T) concentration and fluid intelligence (nonverbal, spatial) was studied in consistently right-handed men with successful (S) or unsuccessful educational levels (NS). Hand preference was assessed by the Edinburgh Handedness Inventory. Nonverbal intelligence was measured by Cattell's Culture Fair Intelligence Test. Serum T level was determined using chemiluminescence enzyme-immunoassay on hormone autoanalyzer. There was no significant difference between the mean T levels of the S subjects and NS subjects, although S-men tended to have higher T levels than NS-men. The mean IQ was found to be significantly higher in S-men than NS-men. In the total sample (S + NS men), the correlation between T to IQ was best described by a polynomial regression (3rd order), exhibiting an inverse U-shaped regression. In S-men, the relationship between T and IQ was best described by a polynomial regression equation of the 3rd order; however, the relationship was not U-shaped, but rather a positive correlation (low T: low IQ and high T high IQ). In NS-men, there was an inverse U-shaped correlation between T and IQ (low and very high T: low IQ and moderate T: high IQ). The present data suggest that (i) very low and very high serum T concentrations may be disadvantageous, (ii) moderate T levels may be advantageous for general fluid intelligence, and (iii) a prewired cerebral organization may be essential for the T effects on cognitive abilities.

Adult↗
PubMed2000

Autosomal recessive multiple pterygium syndrome: a new variant?

Multiple pterygium syndromes include at least 15 different entities characterized by multiple pterygia or webs of the skin and multiple congenital anomalies. We describe a female infant who presented with a distinct constellation of multiple anomalies consisting of pterygia of the inguinal, intercrural and popliteal areas, flexion contractures and arthrogryposis of some joints, craniofacial anomalies including ectropion, medial canthal web, blepharophimosis, hypoplasia of nose, oral and nasopharyngeal cavities, vocal cords and tongue, micrognathia, orolabial synechiae secondary to pterygia, low set ears, alopecia, sad and expressionless face, short neck, asymmetric nipples, anal stenosis, rectal polyp, hypoplastic labia majora, complete syndactyly of all fingers and toes, pes equinovarus, bandlike web between feet, and absence of the nails and phalangeal-palmar creases. Radiological examination showed synostosis, absence or hypoplasia of metacarpal, metatarsal and phalangeal bones on feet and hands, and hypoplasia of pelvic bones and scapulae. This pattern of anomalies does not fit entirely any of the known multiple pterygium syndromes. Autosomal recessive inheritance is most likely due to the presence of three similarly affected siblings and normal parents.

Abnormalities, Multiple↗
PubMed1999

Double layered autogenous vein graft patch reconstruction of the common carotid-internal jugular fistula caused by gunshot wound.

Hereby we present a case with a common carotid-internal jugular fistula caused by gunshot wound. The patient was a 32-year old male who had an entrance hole of a bullet on his right anterior cervical area, at the C4 level with a hematoma surrounding it. The exit hole could be detected at the sublingual area. By palpation a thrill and on auscultation a souffle was noted. Neither crepitation, nor any neurologic deficit or any symptom of Horner's syndrome was present. The emergency digital subtraction angiography (DSA) showed a fistulisation to internal jugular vein (IJV) approximately 0.5 cm below the common carotid artery (CCA) bifurcation level. During the operation a hematoma and a false aneurysm was observed on the CCA. Also, proximally to the bifurcation, a communication of CCA with IJV was noted. The wall of the JJV was rather thinned and the size of the vessel had considerably enlarged. Following the evacuation of the hematoma and debridement, the integration of the artery was achieved by placing a double layered autogenous vein graft patch over the 0.5 x 1.5 cm defect. The 0.3 x 1.5 cm defect laterally over the IJV was primarily sutured. The patient was discharged on the fifth day. The control DSA taken on the twelfth day showed a perfect integration of the vessels. We considered the case noticeable due to its rather rare incidence and the double layered autogen vein patch graft reconstruction.

Adult↗
PubMed1999

Roberts SC phocomelia with isolated cleft palate, thrombocytopenia, and eosinophilia.

The Roberts-SC (Pseudothalidomide) syndrome is a rare autosomal recessive disorder. We present a Roberts-SC Syndrome in a 20-day-old girl with phocomelia of the upper limbs, isolated cleft palate, micrognathia, prominent eyes, pectus excavatum, and pes equinovarus. Peripheral blood smear revealed thrombocytopenia and hypereosinophilia. Premature centromere separation in the child and also in her normal mother was noted.

Cleft Palate↗
PubMed1998

Inhibition of penile erection in rats by a long-acting somatostatin analogue, octreotide (SMS 201-995).

OBJECTIVE: To assess the effect of a new somatostatin analogue (SMS 201-995, octreotide) on erectile function in rats. MATERIALS AND METHODS: Animals were fasted and anaesthetized intraperitoneally with pentobarbital. A cannula was placed in the trachea and the femoral vein cannulated for intravenous infusion. The hypogastric and pelvic nerve, major pelvic ganglion, and the nerve fibres to the lower genitourinary tract were identified. In 20 animals, these nerves were stimulated unilaterally using bipolar silver-wire electrodes; the stimulation was repeated every 15 min for 1 h. Twenty animals were divided into two equal groups; after measuring penile erection to obtain basal values, the animals received either saline or 50 micrograms SMS 201-995 over 1 h and 30 min later, the stimulation was repeated. RESULTS: After administering SMS 201-995 or saline, the levels of penile erection reduced linearly in both groups, but SMS 201-995 caused a greater decrease than in the control group (P < 0.05) and from baseline (P < 0.01) at all times. CONCLUSION: SMS 201-995 inhibits penile erection in rats and the systems may serve as an in vivo animal model for further investigation.

Animals↗
PubMed1998

Cholesterol crystal embolism. Case report.

A 60-year-old man presented with a cholesterol crystal embolism that gave a rather confusing clinical picture. An immediate multidisciplinary approach established the diagnosis and the rapid, dramatic skin loss that exposed vital structures over his thigh and lower leg was reconstructed by an ipsilateral inferior pedicled rectus abdominis musculocutaneous flap with a lateral oblique cephalad fasciocutaneal component. The case, which a plastic surgeon would rarely encounter, is interesting because of the diagnostic approach and the management.

Debridement↗
PubMed1995

Congenital epulis. Case report.

A newborn baby boy weighing 3100 g was found to have a pinky red solid mass 3 x 2.5 x 2 cm arising from the anterior ridge of the maxilla. This caused difficulty in feeding, and looked ugly. The mass was excised under local anaesthetic when he was 2 days old and histological examination showed congenital epulis. He also had a stage II congenital goitre. His hypothyroidism was treated with L-thyroxine sodium and he was well with no sign of recurrence of the tumour at the age of 1 year.

Cell Nucleolus↗
PubMed1993

Sexual dimorphism in linear measures of the corpus callosum in cats.

The sexual dimorphism in the linear measures of the corpus callosum was studied in adult cats. In absolute measures, males had significantly larger genu, isthmus, and splenium than females; the mean absolute lengths were not significantly different in males and females. There were significant positive linear correlations between callosal measures and brain weight in the male and female cats, (no significant correlation between isthmus width and brain weight in females). The mean callosal measures predicted from brain weights in regression equations were found to be significantly greater in males than in females. This sexual dimorphism in callosal measures of cats showed similarities with rats, but not with humans. It was suggested that this may be due to cognitive differences between animal and human brains as well as brain development under relatively simple environmental factors such as gonadal hormones (testosterone) in animals compared to human brains.

Animals↗
PubMed1993

Sexual dimorphism in body and brain weight and its association with paw preference in cats.

Sexual dimorphism in body and brain weight was studied in cats. Paw preference was assessed by food reaching test. Sexual dimorphism in body weight related to paw preference. Males weighted more than females in total sample and non-right-handed (NRH) cats (no significant difference in right-handed group). NRH males weighted more than right-handed (RH) males (no difference in females). Absolute total-brain weight did not show sexual dimorphism. Relative total-brain weight was sexually dimorphic only in NRH cats (females more than males). RH males weighted more than NRH males (no significant difference in females). Only absolute right-brain weighted more in males than females (total sample). Otherwise, no significant difference was found between absolute right- and left-brain weights of male and female cats. The relative right- and left-brain weighted more in females than males only in NRH cats (no sexual dimorphism in RH cats); more in RH males than NRH males; no difference in RH and NRH females. The overall results indicated that sexual dimorphism in body and brain weight is associated with cerebral lateralization in cats.

Animals↗
PubMed1993

The end point of the sylvian fissure is higher on the right than the left in cat brain as in human brain.

The height of the end point of the sylvian fissure (SF) was analyzed in the right and left brains of male and female adult cats. A corrected SF asymmetry coefficient (AC) was computed for each brain. An AC larger than zero (AC+) showed a rightward asymmetry, and an AC smaller than zero (AC-) a leftward asymmetry. In the total sample, ACs fit a normal distribution with a mean significantly larger than zero. Of these brains, 75% had ACs larger than zero median; 23.4% had ACs smaller than zero median. Of 11 right-pawed cats, 90.9% had ACs larger than zero. Of 13 left-pawed male cats, there was no significant difference between AC+ and AC- brains. In right-pawed female cats, the right SF was also higher in most animals, but the difference did not reach the 5% significance level. In left-pawed female cats, the number of AC+ brains significantly exceeded that of AC-brains. Thus, the brains of the left-pawed male cats resembled those of the right-pawed female cats; right-pawed male cats resembled left-pawed female cats with regard to asymmetries in SF height. It was concluded that the human brain is not unique in SF asymmetries, which may be linked to manual asymmetry and sex hormones.

Animals↗
PubMed1993

The role of right- and left-brain weights in cerebral lateralization of right- and left-pawed male and female cats.

The contributions of right- and left-brain weights to the ratio of the left- to the right-brain weight (L/R) were studied in cats. Brain weight was expressed as the ratio of brain weight to body weight. The relative right- and left-brains in the right-pawed male cats were found to be heavier and more asymmetric (L/R < 0) than those in the left-pawed male cats. Only in right-pawed males was the mean L/R ratio found to be significantly smaller than zero. The left-pawed males had smaller and more symmetric brains than the right-pawed males. There was no significant difference between L/R ratios in the right-pawed and left-pawed females. The mean L-R brain weight was found to be significantly smaller than zero in the right-pawed male and left-pawed female cats (no significant difference in other samples). The L/R ratio linearly increased as the relative right-brain weight decreased in the right-pawed and left-pawed males; the L/R ratio linearly increased as the right-brain weight and especially the left-brain weight increased in the right-pawed and left-pawed females. These results partly supported the testosterone hypothesis of cerebral lateralization. The results have also suggested that the right brain in males and the left brain in females would be the main factor determining cerebral lateralization in cats.

Animals↗
PubMed1993

Grasp reflex strength from right and left hands is associated with pH stressor from the umbilical arterial blood in human newborns: handedness and sex-related differences.

Grasp reflex and its asymmetry was studied in relation to pH of the umbilical blood in human newborns, to examine whether the degree of acidity in fetal blood (birth stress) is associated with cerebral laterality. Low pH values were considered as an index for birth stress. Grasp-reflex strength was found to be directly related to pH in total sample. There were sex-related differences. Namely, this correlation was true only for female newborns, not for males. Right minus left grasp-reflex strength linearly increased with pH, i.e., low pH values were associated with left-hand dominance, but only in males. The grasp-reflex asymmetry was not related to pH in females. It was concluded that blood pH may be associated with motor asymmetry and motor development in human newborns, but show sex-related differences; female brain seemed to be more sensitive to pH changes than male brain. The results partly supported the Bakan's hypothesis that birth stress may be associated with left-handedness.

Dominance, Cerebral↗
PubMed1993

Prefabricated microvascular shoulder free flap for forehead reconstruction.

In a case with a large forehead defect following tight scalp bandaging in childhood, a prefabricated microvascular shoulder free flap was used for reconstruction. A free forearm fascial flap, with the radial artery and the concomitant vein as pedicle, was harvested and inserted under a subcutaneous pocket opened in the left shoulder region which served as the future "prefabricated free flap". In addition, a tissue expander was placed in this pocket to provide the necessary tissue expansion to enable primary donor site closure.

Adolescent↗
PubMed1992

The lateralization of the grasp reflex in human newborns.

The strength of the grasp reflex from the right and left hands was estimated in male and female newborns within the second day after birth. In the total sample (N = 121), the mean strength of the grasp reflex from the right hand was found to be significantly higher than that from the left hand. There was a significant positive linear correlation between reflex strengths from the right and left hands. The mean right minus left (R - L) reflex strength was found to be significantly larger than zero. There was a positive linear relationship between the R-L reflex strength and the reflex strengths from the right and left hands. This was more pronounced for the right hand than the left hand. The reflex strengths from the right and left hands were found to be positively linearly correlated with the weight of the newborn babies. These results indicated a grasp reflex lateralization in newborns. The right-bias in the grasp-reflex asymmetry established in this work would create a basis for the development of the right-hand preference in adulthood.

Body Weight↗
PubMed1992

There is a relatively left-biased grasp-reflex asymmetry in human newborns with familial sinistrality compared to those without familial sinistrality.

Grasp-reflex asymmetry was studied in human newborns with regard to familial sinistrality (FS). In the total sample, the following results were obtained. The mean grasp-reflex strength from the right hand was found to be significantly greater than that from the left hand in FS- subjects. There was no significant difference between these parameters in FS+ subjects. The mean right minus left (R-L) reflex strength was significantly greater than zero in FS- subjects. The mean R-L reflex did not significantly differ from zero in FS+ subjects. The mean reflex strength from the right hand was found to be significantly greater in FS- subjects than FS+ subjects. There was no significant difference between the mean reflex strengths from the left hands of the FS- and FS+ subjects. The mean R-L reflex in subjects FS- was found to be significantly greater than that in FS+ subjects. Similar results were obtained from the male and female subjects. It was concluded that FS is an important factor determining the degree of the grasp-reflex asymmetry in newborns. The relatively left-biased grasp-reflex asymmetry under the influence of FS indicates a genetic origin of the motor asymmetry in newborns. This, in turn, suggests that cerebral lateralization inducing manual asymmetry in humans may have been preprogrammed genetically.

Female↗
PubMed1992

Lateralization of the grasp reflex in male and female human newborns.

The lateralization of the grasp reflex was studied in male and female newborns. The mean grasp-reflex strength of the right hand was found to be higher than that of the left hand in males, but the difference was not significant. The mean grasp-reflex strength of the right hand was found to be significantly higher than that of the left hand in females. There was no significant difference between the mean grasp-reflex strengths of the right hand in the male and female subjects. The mean reflex strength of the left hand was found to be higher in males than females; the difference was only marginally significant. The right minus left (R - L) reflex strength showed a significant positive linear relation to the right-and left-reflex strengths in both sexes. This was, however, much more pronounced for the right-reflex than the left-reflex. There was a significantly positive linear correlation between the reflex strengths of the right and left hands and the body weight in males. The females did not show such a relationship between reflex strength and body weight. These sex-related differences in the grasp reflex in newborns were discussed in light of cerebral lateralization and its hormonal modulation.

Body Weight↗