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Biomedical subjects

N Kutlu

Publications and source records attributed to N Kutlu.

At least 37 records · Page 2Linked to original sources
PubMed1992

The relationships between the degree of grasp-reflex asymmetry, grasp-reflex strength from the right and left hands, and body weight in the male and female newborn with and without familial sinistrality.

The relation of the degree of grasp-reflex asymmetry to the strength of right- and left-hand grasp-reflex strength and body weight was studied in human newborn. In the total sample (N = 103), the right minus left (R-L) reflex strength was found to be positively linearly related to the grasp-reflex strengths from the right and left hands in FS-subjects; the correlation was higher for the right hand than the left hand. In FS+ subjects (N = 17), there was not a significant correlation between R-L and right-reflex strength; left-reflex strength was found to be negatively linearly related to the R-L reflex strength. In FS- subjects, the right- and left-reflex strengths showed a positive linear correlation with body weight. In FS+ subjects, only the left-reflex showed a positive linear correlation with body weight. The R-L reflex tended to be positively correlated with body weight in FS- subjects and negatively correlated in FS+ subjects. In females (N = 58), the relation of R-L to right and left reflex was similar to that for the total sample. There was no significant correlation between grasp reflex and body weight in FS- females. In FS+ females (N = 8), there was a positive linear correlation between the right grasp-reflex and body weight; the left grasp-reflex did not show such a significant correlation. The R-L grasp-reflex strength was not correlated with body weight in females.(ABSTRACT TRUNCATED AT 250 WORDS)

Body Weight↗
PubMed1992

Right-, left-dominance and ambidexterity in grasp reflex in human newborn: importance of left brain in cerebral lateralization.

The grasp reflex was studied in human newborn without familial sinistrality. Of 60 females, 26 (43.3%) were right-handed and 34 (56.7%) ambidextrous. Of 62 males, 20 (32.3%) were right-handed, 39 (62.9%) ambidextrous, and 3 (4.8%) left-handed. There was a nonsignificant preponderance of right-dominance in females and a significant preponderance of nonright-handedness in males. In right-handers, the mean right minus left (R-L) grasp-reflex showed a positive linear correlation with the grasp-reflex from the right and left hands, with a higher correlation for the right hand. In ambidexters, the R-L grasp reflex did not show any significant correlation with the grasp reflex from the right and left hands. The mean grasp-reflex from right and left were found to be significantly smaller in ambidextrous males and females then right-handed males and females, with a much higher significance for the right hand. It was concluded that females tended to have a more pronounced reflex lateralization than males. The results also indicated that the left brain may be more important than the right brain for the development of a spinocerebral motor lateralization in humans.

Brain↗
PubMed1992

Parkinsonian-like tremor induced by a combined application of chlorpromazine and pentobarbitone in cats with left-paw preference.

A Parkinsonian-like tremor can be induced by a combined application of chlorpromazine and pentobarbitone in cats. Interestingly enough, only cats with left-paw preference were found to have a predisposition to this drug-induced tremor. The cats with ambidexterity and right-preference in paw use did not show any visible tremorogenic action of these drugs. Especially the proximal muscles of all four extremities showed oscillations with a frequency of about 12 per second in all animals tested, which completely disappeared after i.v. application of lioresal, atropine and biperiden. It was suggested that this new drug-induced tremor model may reflect an impairment within the cortico-striato-pallido-thalamo-cortical feedback loop. It was also concluded that left-handers may have an increased predisposition to centrally acting drugs than nonleft-handers.

Animals↗
PubMed1992

Relationship of serum zinc levels to hand preference, skull length and serum gonadal hormone levels in right-handed young adults.

The association between serum zinc (Zn) level and the degree of hand preference was studied in right-handed young adults. Hand preference was scored by the Waterloo Handedness Questionnaire. Serum Zn level was determined by the flow injection analysis-atomic absorption technique. Zinc was found to be positively linearly and significantly correlated with the degree of right hand preference in the sample of males with familial sinistrality (FS+) and FS- females with right eye and right foot preference. There was a negative linear correlation between these variables in FS+ females. Skull length showed a significant negative linear correlation with zinc in FS+ males and females, but a positive linear correlation in FS- females. In FS- females, there was a significant positive linear correlation between serum gonadal hormone binding globulin (GBG) and serum Zn levels. In FS+ males, there was a significant negative linear correlation between serum GBG and Zn levels, and a significant positive linear correlation between serum free testosterone level and serum Zn level. It was suggested that zinc may influence the degree of the right hand preference by hormonal mechanisms according to genetically established brain organization.

Adolescent↗
PubMed1991

Skin suction blister wound exposed to u.v. irradiation: a burn wound model for use in humans.

The effects of exposing blister wounds to u.v. irradiation were assessed in 14 male volunteers, on whose forearms blister wounds (diameter 5 mm, suction set at 200 mmHg below atmospheric for 2 h 15 min, blister roof cut at base), and irradiated blister wounds (as above, in addition u.v. irradiation given selectively for 30 min from a distance of 10 cm), were produced. In non-u.v.-irradiated wounds, flow cessation, assessed by video microscopy (n = 6), was observed in a small proportion of the papillary loop vessels. The oedema adjacent to the wound was poorly developed. Laser Doppler linear scans (n = 8) demonstrated a pronounced hyperaemia in the wound bed and also in the adjacent skin, the reaction subsiding over a few days. The exudation rate, determined by weighing the hydrocolloid dressings applied to the wound, was maximal on day 1 and then rapidly decreased. Epithelialization, assessed evaporimetrically as the time taken for reinstatement of the epidermal water barrier, was complete in 5.1 days. In the u.v.-irradiated wounds the blood flow had ceased in all the papillary loop vessels by day 1, and increased oedema, exudation and hyperaemia at the wound edges were observed. Epithelialization was not significantly retarded by the irradiation injury. After 6 months, slight discolouration of the skin was occasionally observed, but no cosmetically disturbing scars. This benign and standardized wound model in humans--based on a combination of a mechanical suction injury and a superficial radiation burn--may prove to be useful, for instance when studying the effects of burns treatment.

Adult↗
PubMed1991

The distribution of paw preference in right-, left-, and mixed pawed male and female cats: the role of a female right-shift factor in handedness.

The distribution of paw preference was studied in male and female cats. Paw preference was assessed by the food reaching test. Of the total sample (N = 109), 54 (49.5%) cats were found to be right-preferent, 44 (40.4%) left-preferent, and 11 (10.1%) ambidextrous. In females (N = 63), 34 cats (54.0%) were right-preferent, 23 (36.5%) left-preferent, and 6 (9.5%) ambidextrous. The proportion of the right-preferents was found to be significantly higher than that for the left-preferents in females as in humans. Of the male cats (N = 46), 20 (43.5%) were right-preferent, 21 (45.7%) left-preferent, and 5 (10.9%) ambidextrous. The proportion of the strongly right-preferent females (44%) was found to be significantly higher than that of the strongly right-preferent males (28%) as in humans. In the right-preferent animals, the incidence of the moderate left-paw use was found to be higher in males than females. There was no significant difference in the proportions of the strongly left-preferent males and females. It was concluded that the U-shaped distribution of paw preference in cats is largely shaped by females and a prominent left-paw use of males. The results provided evidence for a right-biased paw preference in females compared to males, indicating that females may be responsible for the emergence of cerebral lateralization and hand preference in animals and humans. It was tentatively suggested that a female right-shift factor may be required for the emergence of a right-bias in handedness. The absence of this factor would decrease the chance of being right-handed and increase the vulnerability of the developing brain to environmental influences.

Animals↗
PubMed1991

A simple tremor model induced by pentobarbitone in guinea pig.

We have recently reported that a combined application of chlorpromazine and pentobarbitone induced intermittently occurring tremor bursts in guinea pigs (Tan et al., in press). This was a chance discovery. It will be shown in the present work that chlorpromazine is not essential for this postural tremor; only pentobarbitone in low dosages produced intermittent tremor bursts in guinea pigs lying in a supine position. Chlorpromazine alone was not effective in producing tremor. The pentobarbitone-induced tremors were attenuated by the i.v. application of biperiden or lioresal. These results indicate that these tremors would be produced by the basal ganglia as in Parkinsonism.

Animals↗
PubMed1991

Intermittent tremor-bursts induced by chlorpromazine and pentobarbitone in guinea pigs: a new tremor model.

It was discovered by serendipity that a combined application of chlorpromazine (3.5 mg/kg) and pentobarbitone (20.0 mg/kg) induced intermittent tremor-bursts in four extremities of guinea pigs. This tremor with a prominent extensor activity disappeared after spinalization, indicating a supraspinal process. Biperiden reduced the frequency and amplitude of the tremor, which was further diminished by amantadine. Baclofen was found to be most potent drug in suppressing tremor. It was suggested that the cortico-striato-pallido-thalamo-cortical feedback loop may be impaired by a combined action of chlorpromazine and pentobarbitone. This new animal model for drug-induced tremor would be of considerable importance with regard to physiological, biochemical, pharmacological and pathological aspects of motor control.

Acoustic Stimulation↗
PubMed1990

Paw preference in cats: distribution and sex differences.

Paw preference assessed by a food-reaching test was studied in male and female cats. Of the total sample (N = 66), 34 (51.5%) were right-preferent, 24 (36.4%) left-preferent, and 8 (12.1%) ambilateral. In the total sample, there was evidence for an overall paw preference, general paw preference, right-, and left-paw preference. The distribution of the right- minus left-paw reaches was neither normal, nor U or J shaped. Of the males (N = 24), 10 (41.7%) were right-pawed, 12 (50.5%) left-pawed, and 2 (8.3%) ambilateral. In males, there was evidence for an overall, general, and right-, left-paw preference relative to no preference. The right- minus left-paw reaches fitted to guassian data with two prominent peaks due to the right- and left-preferents. In females (N = 42), 22 (52.4%) were right-preferent, 14 (33.3%) left-preferent, and 6 (14.3%) ambilateral. There was an overall, general, and right-preference but not a left-preference relative to no preference. The distribution of the right- minus left-paw reaches was neither normal nor U or J shaped. The female right-preferents showed a right-bias compared to males. The left-preferent males were more left-preferent than the right-preferent males are right preferent. The mean right- minus left- paw reaches for the female right-preferents were significantly higher than those for the male right-preferents. There was no significant difference between the right- minus left-paw reaches of the male and female left-preferents. The paw preferences exhibited consistency over time; no learning tendencies were established during testing periods for at least 10 days. Considering the mean right-paw reaches for each successive day (N = 10), the mean right-paw uses in the right-preferents was higher in females than males. The mean left-paw uses in left-preferents was about the same for males and females. In males, the mean left-paw uses for the left-pawed males were higher than the right-paw reaches for the male right-preferents. In females, there was no difference between the right paw reaches of the right-preferents and the left-paw reaches of the left-preferents. It was concluded that there is a right-bias in paw preference of cats, which is caused by the female right-preferents under the influence of a biological factor.(ABSTRACT TRUNCATED AT 400 WORDS)

Animals↗
PubMed1990

Vertical trapezius myocutaneous flap for covering wide scalp defects.

The vertical trapezius myocutaneous flap is extremely reliable, with its wide arc of rotation and its considerable soft tissue bulk, when resurfacing major defects following radical tumor surgery in the head and neck region. In this paper, the use of the vertical trapezius myocutaneous flap in the reconstruction of major scalp defects will be presented and its advantages discussed.

Carcinoma, Squamous Cell↗
PubMed1990

A rare case of Kaposi's sarcoma; hand localization.

A case is reported of Kaposi's sarcoma in a very rare location, the palmar surface of the hand. Kaposi's sarcoma, which still has an unresolved etiology has recently gained great interest because of its close association with AIDS. In our case there had been recurrences even after two surgical interventions. The result of the histopathologic examination was reported as "fibrous histiocytoma" but was also suspected to be a "dermatofibroma". We considered malignancy and performed a wide and deep total excision of the lesion. The histopathologic findings showed Kaposi's sarcoma. Discussion persists in the literature whether to apply radiotherapy or surgery for the treatment of the solitary Kaposi's sarcoma lesion. We have thus far obtained a cure after excision.

Adolescent↗
PubMed1989

[Gorlin-Goltz syndrome].

Gorlin-Goltz syndrome has mainly three components; basal cell carcinoma, jaw cysts and skeletal anomalies. However, various cases of this syndrome with over 40 different kinds of components have been reported. In this paper, a case with Gorlin-Goltz syndrome treated in our clinic have been presented and discussed.

Adolescent↗
PubMedDate not supplied

The effects of testosterone on paw preference in adult cats.

The effects of testosterone on paw preference assessed by a food reaching test was studied in adult cats. It was found that tetosterone propionate injected intramuscularly reduced the degree of the right-paw preference in right-preferent female cats. The paw preference of the male cats and left-preferent female cats was not affected by this male sex hormone. It was concluded that testosterone may especially suppress the left brain to induce ambilaterality in right-paw preference in adult female cats.

Animals↗
PubMedDate not supplied

Asymmetrical relationships between the right and left heights of the sylvian end points in right- and left-pawed male and female cats: similarities with planum temporale asymmetries in human brain.

Asymmetry in the height of the right (R) and left (L) Sylvian end points was studied in right- (RH) and left-pawed (LH) male and female cats. Sylvian height was described relatively to brain weight. An asymmetry coefficient (AC) was estimated (R - L/.5*R + L). There was no significant relationship between R + L Sylvian height and AC, in the total sample and in AC- (leftward asymmetry) brains. In AC+ brains (rightward asymmetry), R + L Sylvian height showed an inverse correlation with AC in RH cats, and a direct correlation in LH cats. There was an inverse correlation between left Sylvian height and AC in RH cats, but no correlation in LH cats. There was a direct correlation between right and left Sylvian height and AC. In AC- brains, left Sylvian height had no relation to AC, but there was a direct correlation between right Sylvian height and AC. In AC+ brains, left Sylvian height showed an inverse correlation with AC in RH males and females; a direct correlation only in LH male cats. Right Sylvian height showed a direct relation to AC+ values in RH and LH males and LH females (no correlation in RH females). The results supported the generalization that a brain symmetrical in a given region has more combined cortex than a brain that is asymmetrical for this region, only for RH cats, however (Galaburda et al., 1987).

Animals↗
PubMedDate not supplied

Right and left hand skill in relation to cerebral lateralization in right-handed male and female subjects: the prominent role of the right brain in right-handedness.

The associations between right and left hand skills to cerebral motor lateralization were studied in right-handed subjects with (FS+) and without (FS-) familial sinistrality. Hand preference was assessed by Oldfield questionnaire and hand skill by the peg moving task. The mean peg moving times (PMTs) and their standard deviations (SDs) were calculated for each hand. There was a significant positive linear correlation between the mean right and left hand PMTs. In males, the mean difference between the left and right PMTs (L-R) showed a significant negative linear correlation with the mean right hand PMTs. There was no significant correlation between these parameters in females. The mean L-R PMTs were found to be positively linearly correlated with the mean left hand PMT in FS- males, FS- and FS+ females (no correlation in FS+ males). The results indicated the contribution of the mean left hand PMTs to L-R hand skill is much higher than that of the mean right hand PMTs. In males, there was no significant correlation between SDs of the mean right and left hand PMTs. In females, SD of the mean right hand PMT was found to be positively linearly related to SD of the left hand PMT. In males, L-R SDs were found to be negatively linearly related to SDs of the mean right hand PMTs and positively linearly related to the SDs of the mean left hand PMTs. In females, only the mean left hand PMT positively linearly correlated with L-R SDs. Here again, the left hand prominently influenced the L-R SDs. In males, SD for the mean right hand PMT showed no relation to right hand PMT. There was, however, a negative linear correlation between SD of the mean right hand PMT and the left hand PMT (no correlations in female). It was concluded that the left hand (right brain) would be of higher significance than the right hand (left brain) in determining the degree of the right-bias in hand skill and its stability in right-handers.

Adult↗
PubMedDate not supplied

The relationships between paw preference and the right- and left-brain weights in male and female adult cats: ipsilateral and contralateral motor control with regard to asymmetric postural and manipulative actions.

Paw preference (food reaching) with regard to relative right-and left-brain weights was studied in adult cats. In the right-pawed (RH) male and female cats, the right-paw use increased and the left-paw use decreased with increasing asymmetry coefficient (AC) for the right- and left brain-weight. The right-paw use increased with increasing the right-brain weight in RH males, and decreased with increasing the left-brain weight in RH females. There was no significant correlation between paw use and AC in left-pawed (LH) males; the right-paw use decreased and the left paw use increased with increasing AC in LH females. The right-paw use decreased with increasing left brain weight (no correlation with right brain) in LH males. In LH females, the right-paw use decreased with the right-brain weight, and increased with the left-brain weight. The left-paw use increased with the left-brain weight in LH males (no correlation with the right-brain weight). The left-paw use increased with the right-brain weight and decreased with the left-brain weight in LH females. These results were explained by supraspinal and spinal reciprocal interactions between the postural and manipulative systems with regard to contralaterality and ipsilaterality of motor control in cerebral and manual lateralization.

Animals↗
PubMedDate not supplied

Relationships among weights of right and left cerebral hemispheres, and right minus left brain weight in right- and left-pawed male and female cats: importance of body weight.

Interrelationships among the right- (R), left- (L) brain weights, R-L brain weight, and R + L brain weight were studied in adult cats. The raw brain weights and the brain weights relative to body weight (brain weight: body weight) were studied separately. The raw R-L brain weight showed no significant correlation with the raw R+L brain weight. The relative R-L brain weight was found to be positively linearly correlated with the R + L brain weight only in the right-pawed (RH) males. So, the asymmetry in relative brain weight increased with the relative total brain weight only in RH males, suggesting a common factor favoring an asymmetrical brain and an increased body weight (testosterone). The relative R- and L-brain weights were found to be inversely related to the relative R-L brain weight only in the RH female cats with R-L brain weight smaller than zero (testosterone in males, estrogen in females). It was concluded that hormonal factors influencing the body weight may also influence the asymmetrical brain development in cats.

Animals↗