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N Lambert-Zechovsky

Publications and source records attributed to N Lambert-Zechovsky.

119 records · Page 7Linked to original sources
PubMed1977

[Current flora of mandibular osteomyelitis].

1) Blood-borne osteomyelitis may have a dental portal of entry. This results in a bacteraemia or septicaemia due to organisms other than staphylococci. In such cases, osseous lesions occur at a distance from the initial dental site. 2) As far as antibiotic treatment is concerned:--It must be begun early but not prematurely, i.e. bacteriological studies should be undertaken before antibotic therapy is started, possibly to be later changed in the light of laboratory results.--It should be combined, with a preference for two antibiotics which result in a bactericidal combination, as soon as the responsible organism is identified.--It should be given in high dosage, in view of the problem of diffusion of the antibiotic to the centre of the necrotic bone lesion.--It should be prolonged, based upon clinical, laboratory and radiological findings.

Bacteria↗
PubMedDate not supplied

Early synergistic killing activity at concentrations attainable in CSF of amoxicillin or cefotaxime and aminoglycosides against Haemophilus influenzae.

Rapid eradication of bacteria from the CSF is critical for the outcome of Haemophilus influenzae meningitis in children. In 15 patients studied, the mean H. influenzae colony counts in CSF were 10(5) CFU/ml (range: 10(2) to 10(9) CFU/ml). Time-kill curves were determined for amoxicillin and cefotaxime alone and in combination with gentamicin or amikacin, against 60 clinical isolates of H. influenzae at concentrations equivalent to those found in CSF following systemic administration. Against beta-lactamase-negative strains (n = 44) a bactericidal effect was observed at 18 h for amoxicillin alone, at 5 h for amoxicillin plus aminoglycosides and at 2.5 h for cefotaxime with or without aminoglycosides. Against beta-lactamase-positive strains a bactericidal effect was observed at 18 h for cefotaxime, at 5 h for amoxicillin plus aminoglycosides and at 2.5 h for cefotaxime plus aminoglycosides. It appears that despite low concentrations of gentamicin or amikacin in the CSF, the accelerated killing of H. influenzae provides a rationale for the initial use of the combination of cefotaxime and aminoglycosides in the initial treatment of H. influenzae meningitis.

Aminoglycosides↗
PubMedDate not supplied

Analysis of a case of recurrent bacteraemia due to group A Streptococcus equisimilis by pulsed-field gel electrophoresis.

An 86-year-old woman with a history of metastatic breast cancer developed two episodes of streptococcal bacteraemia and erysipelas separated by an interval of 3 months. The isolates belonged to Lancefield group A but were biochemically identified as Streptococcus equisimilis. The similarity of the two isolates was established by DNA macrorestriction analysis and pulsed-field gel electrophoresis, indicating that the second episode was due to relapse and not reinfection.

Aged↗
PubMedDate not supplied

Comparative activity of beta-lactam antibiotics against 'intrinsically' ticarcillin-resistant strains of Pseudomonas aeruginosa.

The in vitro activity of piperacillin, cefoperazone, cefsulodin, ceftazidime, aztreonam and imipenem was studied against 44 isolates of Pseudomonas aeruginosa with 'intrinsic' resistance to ticarcillin in comparison with 20 ticarcillin-susceptible strains, by MIC determination and the disk diffusion test. The activity of the antibiotics, imipenem excepted, against the resistant strains was reduced when compared to the susceptible strains. The most significant reduction was found for aztreonam and the least significant for ceftazidime. When considering the breakpoints, all strains were intermediate with aztreonam and cefoperazone, but most of them remained susceptible to ceftazidime, piperacillin and cefsulodin.

Anti-Bacterial Agents↗
PubMedDate not supplied

Activities of piperacillin, ceftazidime, cefepime and cefpirome against Pseudomonas aeruginosa strains with intrinsic ticarcillin resistance.

The in vitro activities of cefepime and cefpirome against 44 intrinsically ticarcillin-resistant strains of Pseudomonas aeruginosa were compared to their activities against 20 ticarcillin-susceptible strains by MIC determination and the disk test. Time-killing curves were constructed for piperacillin, ceftazidime, cefepime and cefpirome against two susceptible and two resistant strains. The activities of cefepime and cefpirome against the resistant strains were impaired, and most of the strains were of intermediate sensitivity to these agents. The time-killing curves of the four beta-lactams were similar, with a modest decline in viable cell counts over the first 6 h followed by regrowth. There was no difference between the susceptible and resistant strains.

Anti-Bacterial Agents↗
PubMedDate not supplied

[R plasmids incompatibility groups in epidemic Salmonella (author's transl)].

The susceptibility to antimicrobial agents of 410 strains belonging to six serotypes of epidemic Salmonella (S. wien, S. saint-paul, S. panama, S. heidelberg, S. isangi and S. brandenburg) was studied. Resistance to one or more antibiotics was shown for 228 of these strains. Study of resistance transfer was investigated for 25 multiresistant strains of different epidemic origin. Resistance was coded for by conjugative R plasmids except in the case of S. brandenburg. From 20 strains of Salmonella, 39 plasmids were transferred to E. coli K12. Twenty-nine of these plasmids were classified into 7 incompatibility groups: IncFI, FII, I1, I2, N, C, M. These same groups were also found for 84 R plasmids from different enterobacteria. The "epidemic character" of these Salmonella serotypes does not seem to be associated with carriage of any particular R plasmid.

Anti-Bacterial Agents↗