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Biomedical subjects

N M Ivanova

Publications and source records attributed to N M Ivanova.

32 records · Page 2Linked to original sources

[Circulating immune complexes in inflammatory lung diseases and their relation to infectious factors].

The results obtained in the study of the intensity and duration of the circulation of immune complexes in the peripheral blood in 59 patients with acute pneumonia and in 120 patients with chronic bronchitis, as well as the reaction of these complexes to etiologically important bacterial antigens (pneumococcal, staphylococcal, type b Haemophilus influenzae, streptococcal), are presented.

Adolescent↗

[Immune system characteristics in acute pneumonia].

In 76 patients with acute pneumonia the absolute and relative numbers of T- and B-lymphocytes and their functional activity were determined on the basis of the data on the immunoglobulin level and lymphocyte blast-transformation with phytohemagglutinine. The character of the immune response of the patients was found to depend on the activity of the inflammatory process, its spread and the features of the clinical course of the disease. The most pronounced changes in the immune system of the patients (a sharp decrease in the number and function of T- and B-lymphocytes) were observed in croupous pneumonia and in the prolonged course of local pneumonia, as well as in cases of considerable lesion of the pulmonary tissue (3-6 and more segments).

Acute Disease↗

[Isolation and properties of leucine aminopeptidase from Aspergillus oryzae].

Homogenious leucine aminopeptidase is purified from "oryzine"--mixture of enzymes produced by surface culture of Asperigillus oryzae using treatment with activated characoal, followed by DEAE-cellulose and hydroxylapatite chromatographies, Biogel P-100 gel-filtration and polyacrylamide-gel electrophoresis. The enzyme has pH optimum 9.0 and the molecular weight 37500 as estimated by gil-filtration through Sephadex G-100 (superfine) and SDS-polyacrylamide gel electrophoresis. Leucine aminopeptidase from Asp. oryzae has a broad substrate specificity, therefore, cleaving with the highest rate the peptides carrying N-terminal leucine. The enzyme is completely inhibited with EDTA and beta-mercaptoethanol, and it is a metalloenzyme.

Aspergillus↗

[Therapeutic pathomorphism of Ewing's tumor].

Pathomorphosis of Ewing's tumors after the combined treatment is studied with the use of light and electron microscopy, DNA-flow cytometry. Necrosis and apoptosis of tumor cells produced by the therapy are characterized. Therapeutic forms of tumor cells representing hyperaneuploid population delayed at the G2-level of the cell cycle are described.

Antineoplastic Agents↗