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N M Kolomoets

Publications and source records attributed to N M Kolomoets.

25 records · Page 2Linked to original sources
PubMed1994

[The clinical course of acute pneumonia in servicemen in Afghanistan].

The study of 820 histories was carried out in order to ascertain characteristic features of clinical course of acute pneumonia in the conditions of Afghanistan. All these patients underwent treatment in the Central Military Hospital of the 40th Army in Kabul in 1980-1989. The immunity status, the the level of peroxide oxidation of lipids (POL), and the state of antioxidant system (AOS) were also studied in 132 patients. The clinical course of pneumonia in comparison with its manifestation on the territory of Russia was characterized by pronounced intoxication of an organism, broncho-obstruction, vast inflammatory infiltration, hyperactivization of the immune system, POL, and AOS exhaustion. All these factors correspond to the syndrome of disadoptative disorders. Medications recommended for complex treatment: antioxidants, immunoglobulins, albumin, low-molecular dextrans.

Acute Disease↗
PubMed1989

[Pathogenesis of acute pneumonia].

The patients with acute pneumonias demonstrated interdependent changes in lipid peroxidation (LPO), antioxidant system (AOS), immune system (IS), and in the pituitary-adrenocortical system (PAS), related to the character of the disease course. The most pronounced changes were seen in the patients with acute pneumonias eventuating in pneumofibrosis. The high level of LPO was combined with AOS depletion, immunodeficiency formation, and with dysfunction of the PAS. Antibacterial treatment did not exert any appreciable effect on the characteristics under study. Thus, the level of LPO and AOS status are important components in the pathogenesis of acute pneumonias, determining the character of the disease course and outcome. It is advisable that research work aimed at the design of the principles of antioxidant therapy may be intensified.

Acute Disease↗