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Biomedical subjects

N Mikata

Publications and source records attributed to N Mikata.

31 records · Page 2Linked to original sources
PubMed1986

[Multiple imaging procedures including MRI in bladder cancer].

Endoscopic photography, double contrast cystography, transurethral echography, X-ray CT scan, and MRI (magnetic resonance imaging) were utilized for the staging diagnosis of the four patients with carcinoma of the bladder. In the first case, a 70-year-old man, since all of the five imaging procedures suggested a superficial and pedunculated tumor, his bladder cancer was considered T1. The classification of stage T3 carcinoma was made for the second 86-year-old male. Because all of his imaging examinations showed a tumor infiltrating deep muscle and penetrating the bladder wall. The third case was a 36-year-old male. His clinical stage was diagnosed as T2 or T3a by cystophotography, double contrast cystogram, ultrasonography, and X-ray CT scan. However, MRI showed only thickened bladder wall and the infiltrating tumor could not be distinguished from the hypertrophic wall. The last patient, a 85-year-old female, had a smaller Ta cancer. Her double contrast cystography revealed the small tumor at the lateral bladder wall. But, the tumor could not be detected by transaxial, sagittal and coronal scans. Multiple imaging procedures combining MRI and staging diagnosis of the bladder carcinoma were discussed.

Adult↗
PubMed1986

[Synchronously diagnosed and treated triple cancer (rectum-ureter-prostate)].

A 63-year-old man was admitted for examination of a rectal tumor. A stony hard nodule was palpated in his swollen prostate by rectal examination. The biopsies proved rectal and prostate carcinoma. Transabdominal echogram and DIP showed left hydronephrosis. Left ureteral cancer was suggested by the typical "goblet sign" with retrograde ureterography. Rectal lower anterior resection, left total nephroureterectomy with partial cystectomy, castration and pelvic lymphadenectomy were undertaken synchronously. The pathohistological diagnosis was triple cancer consisting of rectal mucotubular adenocarcinoma, prostatic carcinoma and ureteral transitional cell carcinoma. The diagnosis and treatment of the triple cancer were discussed.

Adenocarcinoma↗
PubMed1986

[Changes in renal function on response to rapid administration of cisplatinum].

Seven patients with urologic carcinomas were examined for changes in renal function as a result of administration of Cisplatinum (CDDP) at a high rate of 50 or 100 mg/m2 within 5 hours, superimposing 2 liters of fluid before and after the CDDP dose, and the results were compared with the pretreatment values. Renal function tests revealed that BUN was elevated to 20 mg/dl or more in 5 but not beyond 30 mg/dl in any of the patients, that serum creatinine was elevated to 1.4 mg/dl or more in 3 cases with a maximum of 1.5 mg/dl, and that Ccr was decreased to less than 70% of the pretreatment value in 3 patients. These manifestations of imparied renal function were all transient and reversible, being mostly restored to the pretreatment values during or within 1 month after the end of CDDP treatment, and did not necessitate the discontinuation of the treatment in any patients. The above findings proved the rapid infusion of CDDP to be as safe in terms of renal function as prolonged, continued i.v. infusion of the drug, which would these fore make CDDP treatment of outpatients possible.

Aged↗
PubMed1985

Spindle and giant cell carcinoma of the bladder. Report of 3 cases.

3 cases of spindle and giant cell carcinoma are reported. 2 patients with T3N0M0 and T3N1M0 tumors underwent radical cystectomy. They died 8 and 9 months after cystectomy for local recurrence and tumor metastases. Neither radiotherapy nor chemotherapy were effective in these 2 patients. 1 patient with T1NXM0 disease underwent resection of the tumor through cystotomy. Although she had neither adjuvant chemotherapy nor radiotherapy, she is well without recurrence 6 years after surgery. Early surgical resection of the tumor may be the only currently accepted therapy of spindle and giant cell carcinoma of the bladder.

Aged↗
PubMed1983

[Synchronous double cancer of the esophagus and the urinary bladder: report of two cases].

An 82-year-old man was seen with the complaints of gross hematuria and dysphagia in September 1979. An invasive bladder tumor was found and TUR-Bt (Transitional cell carcinoma, G2, pT3NXMO ) was performed. Fluoroscopic examination revealed a large esophageal cancer (Undifferentiated squamous cell carcinoma, T2NXMO ) and irradiation was performed (Linac 4,600 rads). The patient's condition aggravated rapidly and he died in February 1980. A 76-year-old man irradiated for an esophageal cancer (Linac 6,540 rads) (undifferentiated squamous cell carcinoma, T1NXMO ) in March 1981. Eleven months later, bladder cancer was found and treated with TUR-Bt (Transitional cell carcinoma, G2, PTlmNXMO ) followed by intravesical instillation of carboquone and adriamycin. The patient was alive 1 year and 9 months after the diagnosis of the esophageal cancer. Sixteen cases of double cancer of the esophagus and urinary bladder were found in the Japanese literature. Eighteen cases including the above 2 cases were males and their ages ranged from 51 to 82 years. Sixteen bladder cancers were transitional cell carcinoma and 15 esophagus cancers were squamous cell carcinoma. Of 9 cases whose clinical course were described in detail, 3 were synchronous and 6 were metachronous. Radical surgery was performed for one or both of the two cancers in 5 cases, 4 of which were metachronous. Indication of surgery for the metachronous second cancer does not differ significantly from sporadic cancer when the first cancer has been managed successfully. However, the treatment for the synchronous double cancer of this type of combination is often forced to be restricted, since the prognosis of esophageal cancer is poor and surgical risk may be increased by two radical surgeries in such elderly patients.

Aged↗
PubMed1983

[Primary multiple cancers related to urological malignancies].

In the course of 5 years, we encountered 11 cases of primary multiple cancers related to urological malignancies at the Department of Urology, Tokyo Metropolitan Komagome Hospital. The patient age at diagnosis of the first cancer ranged from 59 to 77 years (mean 69 years); there were 9 men and 2 women. Of patients with urological malignancies, 6.4% had multiple cancers. All cases were diagnosed clinically and diagnosis was confirmed histologically. In ten patients, second cancers were found within one year. Three cases were combined with urological cancers, six cases with gastric cancer. The clinical course of a patient with renal pelvic-ureteral cancer and gastric carcinoma is presented in detail.

Aged↗
PubMed1983

[Multiple brain metastasis from renal cell carcinoma--a care report].

A 51-year-old woman was admitted with left renal cancer with lung metastasis. Nephrectomy was performed in September 1976. She was readmitted in comatous state 2.3 years later. Excision of multiple brain metastases resulted in recovery of consciousness and she was able to resume her normal life. However, 6 months later, she died of progression of pulmonary metastasis. Autopsy study revealed no cancer recurrence in the brain and left renal fossa. Multiple brain metastases from renal cancer and their treatment are discussed.

Adenocarcinoma↗