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Biomedical subjects

N Milchev

Publications and source records attributed to N Milchev.

At least 19 recordsLinked to original sources
PubMed2006

[Pregnancy in teenagers].

UNLABELLED: Teenage pregnancy is a recognized problem of social and health significance worldwide. World Health Organization considers them as high-risk pregnancies. Teenage birth rates vary by different country. OBJECTIVE: To study the frequency and the obstetric outcome of pregnancy at teenagers in University Hospital "St. George" Plovdiv. SUBJECTS AND METHODS: Nuliparous women who at the period of the delivery were at 11-19 years old and were seen at the obstetric unit of the above hospital were recruited into the study. Observed complications during the pregnancy and delivery were also calculated. RESULTS: For the period of 10 years the teenage pregnancy rate was 8.22%/n= 958/ of all 11657 deliveries /91.78%/. 901 of the teenagers were aged 16 to 19 years /7.73%/ while only 57/0.49%/ were aged 11 to 15 years. In 69.42% /n= 665/ of the cases the deliveries were not complicated; in 30.58% of the cases there were complications or the delivery ended surgicaly. CONCLUSIONS: Pregnancy during teenage years remains major public health problem with lasting repercussions for the teenage mothers and their infants but also for their families and society as a whole. The prevention of the adolescent pregnancy by executing proven and effective programs would decrease its frequency and the complications associated with it.

Adolescent↗
PubMed2006

[Trophoblast expression of EGFR (epidermal growth factor receptor) in the preeclampsia placenta].

UNLABELLED: Placental pathology in preeclampsia and retarded fetuses is associated with changes of the pattern of expression of EGFR. The purpose of this study was to investigate the expression of epidermal growth factor receptor in trophoblast populations of preeclampsia and retarded fetuses in comparison with normal controls. Tissue microarray with paraffin sections containing a general of 90 placental specimens including 30 preeclamptic cases, 30 retarded fetuses and 30 normal pregnancies (controls) were studied immunohistochemically for epidermal growth factor receptor in the syncytiotrophoblast and villous cytotrophoblast. Epidermal growth factor receptor levels were estimated semiquantitatively. The percentage of strong/intermediate immunoreactivity of epidermal growth factor receptor in the syncytiotrophoblast was significantly higher in normal placental cases (98%) than in pathological conditions (P = .03), although strong/intermediate immunoreactivity in the syncytiotrophoblast was significantly lower in pathologic cases (35%) than controls (P < .001). No correlation (P > 0.01) was found between the trophoblast expression of EGFR and the weight of the newborn fetuses. Epidermal growth factor receptor expression in the villous and extravillous cytotrophoblastic cells were significantly different between controls and preeclamptic cases (P > .05). CONCLUSION: The development of pathologic pregnancies is possibly related to the differential expression of epidermal growth factor receptor in the syncytiotrophoblast.

Adult↗
PubMed2006

[The effect of contraceptive with 20 ug ethinylestradiol and 150 ug desogestrel on some acute phase proteins].

BACKGROUND: We present the influence of monophasic combined oral contraceptive with 20 mmicrog ethinylestradiol /150 microg desogestrel upon some acute phase proteins: C- reactive protein, fibrinogen, haptoglobin and the connection between the proinflammatory effect of oestrogens METHODS: Forty clinically healthy young women between 18 and 35 years, using oral contraceptives in the duration of 12 months, are included in this study. RESULTS: We don't find statistically significant differences in the plasma concentrations of C--reactive protein, fibrinogen, haptoglobin on the 12th month of the using of the oral contraceptives in comparision with the initial levels of the variables, before starting the study. CONCLUSION: The reduction of the dose of ethinylestradiol, definitely reduces the effects of oral contraceptives upon acute phase proteins and eventually the increased risk of cardiovascular disease.

Acute-Phase Proteins↗
PubMed2006

[Pregnancy outcomes in women of advanced maternal age].

UNLABELLED: During the last decade there is a trend all over the world women at advanced age/older than 35 years old/ and especially educated ones to postpone their reproductive plans. Pregnancy and birth outcomes in women >35 years old I traditionally associated with increasing risk of complications both for the mother and the foetus. OBJECTIVE: To study the frequency and the obstetric outcome of pregnancy at advanced age women in the University Hospital "St. George" Plovdiv. SUBJECTS AND METHODS: Women who at the period of the delivery were at more than 35 years old and were seen at the obstetric unit of the above hospital were recruited into the study. Observed complications during the pregnancy and delivery were also calculated. RESULTS: For the period of 10 years the teenage pregnancy rate was 5.10% /n= 594/5.10% of all 11657 deliveries /94.90%/. 504 of the patients were aged 35 to 39 years /4. 32%/ while only 90 /0.78%/ were aged > 40 years old. In 54.88% of the cases the deliveries were not complicated; in the rest of the cases there were complications or the delivery ended surgicaly. CONCLUSIONS: The increasing frequency of the advanced age pregnancy and deliveries and improved pre and intranatal counseling has made advanced maternal age compatible with successful pregnancy for the great majority of such women.

Adult↗
PubMed2006

[Obesity and pregnancy].

UNLABELLED: The increasing frequency of preobesity and obesity in all age groups worldwide can be characterized as a pandemia. Obesity is a public health problem because it is a major contributing factor in the development of hypertension, heart disease, type II diabetes, osteoarthritis, respiratory problems and certain cancer. THE OBJECTIVE OF THE STUDY: To describe the prevalence of preobesity and obesity among pregnant women and to evaluate the impact of preobesity and obesity upon pregnancy and delivery. SUBJECTS AND METHODS: 255 women, aged between 17 and 39 years old are conducted in the study. They have been admited to the Clinic of Obstetrics and Gynecology at the University Hospital "St. George" Plovdiv for the period of for months /January- April 2005/. The data of the patients are obtained from their history of the disease and the dokument of the newborn. BMI was calculated before and at the end of pregnancy. RESULTS: Preobesity and obesity are more frequent at more educated women, nuliparous women and women aged 30 years and more. Obese women had a higher frequency of preeclampsia, gestational diabetes, macrosomia, and operative delivery. 33.33% (n=85) of the pregnant women start their pregnancy with abnormal weight or obesity. At the end of the pregnancy 72.94% (n=186) of them are in condition of preobesity and obesity. CONCLUSION: As overweight and obesity are associate with adverse pregnancy outcomes, the attention of the obstetritian must be directed to so called preconceptual consulting in order to limit the gaining of wight upon the optimal limit before and during pregnancy.

Adolescent↗
PubMed2006

[Hyperlipidemic pancreatitis during pregnancy--a case report].

We present a case of acute pancreatitis during pregnancy, associated with hyperlipidemia. The patient, 23 years old in 36 g. w., was hospitalized at the Clinic of Obstetrics and Gynecology with nausea, multiple vomitting, persistent abdominal pain and febrility. Because of the clinical apperance of acute pancreatitis Ceaserean Section was performed with subsequent revision of the abdominal cavity, necrectomy of the pancreas, laparostoma, lavage, drainage, nutritional yienostoma. Intubation with artificial pulmonary ventilation and high volume continuous veno-venous haemofiltration (HV CVVH) was performed because of the development of polyorgan insufficiency and ARDS. After the procedure the patient condition became stable. After four months of hospitalisation, she was discharged from hospital with stable vital signs.

Female↗
PubMed2006

[C-reactive protein in women with pre-eclampsia].

UNLABELLED: Preeclampsia is a disorder associated with generalized dysfunction of endothelial cells probably as a result of systematic inflammatory maternal reaction. CRP is a positive marker of inflammation higher at overt preeclampsia than in normal pregnancy. The aim of the present study is to observe the variations of the acute phase protein CRP at women with preeclampsia and those with normal pregnancy in the third trimester. MATERIAL AND METHODS: Sixty women are included in the study, separated into two groups; group A (n = 30), consisted of women with overt preeclampsia and group B (n = 30)- women with normal pregnancy. Plasma levels of CRP are measured by using immunoturbidimetric method and the results are statistically calculated by variative analysis. RESULTS: We found statistically significant difference in plasma concentration of CRP between pregnant women with preeclampsia and those with normal pregnancy (t = 2.92, P < 0.01). CONCLUSION: In conclusion our data about the significantly higher values of CRP at women with preeclampsia are in agreement with the statement for presence of pronounced inflammation at preeclampsia compared with normal pregnancy.

Biomarkers↗
PubMed2006

[The significance of kinesitherapy for prophylaxis of osteoporosis].

Osteoporosis is a significant public health problem. It is associated with bone fragility resulting mostly from low bone mass and a concomitant increase in the risk for fracture. Physical exercises are commonly prescribed intervention for prophylaxis of osteoporosis. The purpose of the present study is to state the necessity of appliance kynesitherapy under different forms and methods at osteoporosis.

Exercise Therapy↗
PubMed2006

[Effect of oral contraceptives on vaginal flora].

The contraceptive and non contraceptive advantages of oral chormonal contraceptives as well as the good control on fertility, make it one of the most preffered method of contraception. The normal vaginal flora is a dynamic ecosystem and itsequilibrium and status of eubyosis amongst its inhabitants is an important mechanism against exogenous infections. The use of oral contraceptives is not associated with significant changes in the vaginal microbial flora; the normal concentration of the lactobacillli is preserved.

Bacteria, Aerobic↗
PubMed2006

[Thrombophilia and pregnancy].

The incidence of venous thromboembolism is increased five to six times in pregnancy; and it is estimated that thromboembolic episodes- superficial and deep venous thromboembolism and pulmonary embolism occur in 1:1000 to 1:1500 pregnancies. These complications during pregnancy and puerperium, are not common but serious and leading cause of maternal morbidity and mortality. Thrombophilias--acquired or inherited, result of anticoagulant regulatory proteins deficiency, could compromise normal pregnancy by increasing the risk of developing first or recurrent thromboembolic incidents and adverse obstetric events.

Female↗
PubMed2005

[Lymphocyte populations and subpopulations in peripheral blood of pregnant women with pre-eclampsia].

AIM: To investigate the changes of lymphocyte populations and subpopulations in peripheral blood of pregnant women suffering preeclampsia. MATERIAL AND METHODS: By means of flowcytometry the following lymphocyte populations and subpopulations were determined in peripheral blood of 37 pregnant women, of whom 12 had preeclampsia and 25 had normal pregnancy pespectively: Total lymphocyte count CD19+ (B-lymphocytes), CD2+ (Total T-lymphocytes), CD3+ (Immunocompetent T-lymphocytes) CD3+CD4+ (T-helpers), CD3+CD8+ (Suppressor-cytoxic T-lymphocytes), CD4+/CD8+ ratio, Lymphocyte subpopulations with predominant killer activity: CD8-CD56+, CD8+CD56+ and activated immunocompetent T-lymphocytes (CD3+HLADR+). RESULTS: In patients with preeclampsia a T-helper increase and relative T-suppressor cytotoxic decrease was found. A significant increase of activated immunocompetent T-lymphocyte was found, compared to the total increase of immunocompetent T cell. No significant difference between cytotoxic cell with MHC unrestrained function (CD8-CD56+) and cell with MHC restrained cytotoxic function (CD8+CD56+) was found. CONCLUSIONS: In pregnant women with preeclampsia the main lymphocyte populations and the immunocompetent T-lymphocytes are increased. The raised level of T-lymphocytes is found as a result of the substantial quantitative changes of T-helper cells an increase of CD4+/CD8+ ratio is prominent, which is a proof of the activated immune potential in pregnant women with preeclampsia with the dominant influence of T-helper subpopulations.

Antigens, CD↗
PubMed2005

[Proliferation of villous trophoblast and stroma in normal and pathologic pregnancies (preeclampsia)].

Pregnancies, complicated with preeclampsia, present with intrauterine growth retardation of the fetus and small (in size and weight) placentas. The present study aims at establishing the expression of proliferative nuclear antigen Ki-67 in the villous trophoblast and stroma, and to compare the results between study (preeclamptic cases n = 30) and control (normal n = 30) groups. The number of Ki-67 positive nuclei both in the preeclamptic trophoblast and stroma significantly increases those of the controls. Our results show that the defect in the development of the placenta in preeclampsia is not associated with low proliferative potential.

Cell Proliferation↗
PubMed2005

[Mesenteric venous trombosis and pregnancy--a case report and a short review of the problem].

Mesenteric venous thrombosis is extremely rare surgical pathology during pregnancy and frequently is associated with hemoglobinopathies beta-thalassemia, congenital defects of the coagulation and antiphospholipide syndrome. It has nontypical clinical appearance, which hardens the timely diagnosis and the adequate surgical treatment. We present a case of a 22 year-old girl with hemozygote form of beta thalassemia, pregnant in ml II, with mesenteric venose thrombosis. The diagnosis was made on the 24th hour from the beginning of the disease. The patient was operated successfully by a resection of the necrotic changed part of the intestine. She noticed vaginal bleeding due to a missed abortion on the 22nd day after the operation.

Adult↗
PubMed2004

Factor VII deficiency and its treatment in delivery with recombinant factor VII.

The authors present two cases of pregnant women with coagulation disorders--one with inherited deficiency of factor VII and the second with chronic hepatitis. Both cases were successfully treated with recombinant activated factor VII of coagulation (NovoSeven) in delivery. The advantages of using this product are discussed.

Adult↗
PubMed2004

[Effect of low-dose oral contraceptive regulon-Gedeon Richter on some hemostatic variables].

The authors have investigated the changes of some haemostatic variables at 33 women, who used low-dosed oral contraceptive REGULON--Gedeon Richter in the duration of six months. Statistically significant decrease is found in the activity of Protein S and Protein C, but plasminogen level is increased. The levels of the other variables remained in referential ranges. The use of REGULON doesn't influence the coagulation system.

Adolescent↗
PubMed2004

[Socio-economic characteristics of pregnant women with preeclampsia: a gypsies population survey].

Preeclampsia as a serious syndrome affecting both the mother and the baby is associated with a number of socio-economic, demographic and clinical characteristics. We have filed the distribution of major epidemiological parameters in two gypsy groups, comprising 58 preeclamptic and 118 control cases. Only the classical features of preeclampsia as well as single liveborns were included in our study. Data are taken from the medical files and from a direct interview with the patients. Nonparametric and multivariate analysis are applied. The two study groups show insignificant differences in the distribution of the major epidemiological factors. Significant p-values are obtained referring to maternal age, parity, obesity. Speculations as to gypsy lifestyle are discussed as possible explanation to the achieved results.

Adult↗