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Biomedical subjects

N Milchev

Publications and source records attributed to N Milchev.

At least 37 records · Page 2Linked to original sources
PubMed2004

[Effect of the monophase oral contraceptive combination with 20 ug ethinyl estradiol/150 ug desogestrel on haemostasis].

The authors examined the changes in the haemostasis during the use of the oral contraceptive combination with 20 microg ethynil estradiol/150 microg desogestrel at 35 women, a basic group, who used the oral contraceptive in the duration of 12 months and a control group (n=35), who do not use the pills. We found statistically significant increase of Antithrombin III (ATIII) (p<0.011), Cofactor II of Heparin (HCII) (p<0.001), the activity of plasminogen (p<0.026) and beta2-antiplasmin (0.026), significant decrease of Protein C (PrC) (p<0.0001) and of total Protein S (TPrS) (p<0.03) in the basic group in comparision with the control one. We do not observe significant changes in the rest of the haemostatic variables between the two groups. During the use of the oral contraceptive combination with 20 microg ethynil estradiol/150 microg desogestrel the changes in the system of the natural inhibitors are balanced by these in the system of fibrinolysis.

Adolescent↗
PubMed2004

[Postoperative nausea and vomiting--possibility to prevent after long-lasting gynecological operations].

The aim of this study is to establish the possibilities for effective influence upon the postoperative nausea and vomiting and to summarize the existing literature data. The observation is carried out upon 361 patients with performed hysterectomy, who were hospitalised at the Department of Obstetrics and Gynecology of the University Hospital "Saint George" Plovdiv for the period January-December 2003 year. We performed randomized study about the effect of the application of dexamethasone used in the introduction of anaesthesia and its effect upon the postoperative nausea and vomiting. Our observation confirms the literature data about the safe and effective application of dexamethasone as a method of choice for minimizing the frequency of the postoperative nausea and vomiting

Adult↗
PubMed2004

[Perforation of duodenal ulcer in the puerperium--a case report].

The authors present a case of perforated duodenal ulcer in the puerperium at a patient who underwent Ceaserian section. Urgently 12 hours after the perforation relaparotomy was made. The exit of the illness depends on the precise and early diagnosis and subsequent surgical treatment.

Adult↗
PubMed2004

[The effect of two low dose oral contraceptive with gestodene on the systems of natural inhibitors of coagulation].

AIM: The authors investigated the influence of two monophasic oral contraceptives with 30 and 20 microg ethynilestradiol (EE) with combination with 75 microg gestodene (GSD) upon the system of natural inhibitors of coagulation. MATERIALS AND METHODS: The study is prospective for a period of 12 months and was conducted upon 105 clinically healthy women, who use 30 microg EE/75 microg GSD (n = 35), 20 microg EE/75 microg GSD (n = 35) and a control group (n = 35). RESULTS: The continuous use of the contraceptive combination with 20 g EE/75 g GSD leads to statistically significant elevation of protein C (PrC), total protein S (TPrS) and Heparin Cofactor II (HCII). The use of the contraceptive combination with 30 microg EE/75 microg GSD is associated with statistically significant increase of Pr C and HC II. There were no statistically significant changes in the other variables. CONCLUSION: The use of both oral contraceptive combinations is associated with increased anticoagulant activity, which status prevents from thrombosis.

Adolescent↗
PubMed2004

[Treatment of iron-deficiency anaemia with ferrous gluconate].

Twenty women with iron-deficiency anaemia were treated. The distribution of women was as follow: 16 women with metrorrhagia and 4 pregnant women. According the stage of anaemia - 6 of them with slight anaemia, 12 - moderate, 2 of them with severe anaemia. Diagnosis of iron-deficiency anaemia was done on the base of clinical and laboratory dates, including Hb, Er, Fe and Fe-binding capacity measured in periphery blood. "Tot'hema" was prescribed twice daily. Control laboratory investigations were done on 24 and 72 hours. Receiving dates confirmed excellent GI absorption, which guarantee "Tot'tema" efficacy. Reported on all cases very good therapeutic effect and excellent tolerability of "Tot'tema", without side effects.

Adult↗
PubMed2003

[Cytotec: an effective drug for the induction of labor].

OBJECTIVE: Our purpose was to compare the safety and efficacy of intravaginal Cytotec versus Oxytocin for induction of labor. STUDY DESIGN: Two hundredth seventy six of patients with indications for induction of labor were assigned to receive either intravaginal Cytotec or Oxytocin. Cytotec were placed in the posterior vaginal fornix every three (3) hours with a potential maximum of six (6) doses. Oxytocin were administered to a standard protocol of our clinic. RESULTS: Among those evaluated 138 received Cytotec and 137 received Oxytocin. The overage interval from start of induction to vaginal delivery was shorter in the Cytotec group (1332.4 +/- 846.5 min) than in the Oxytocin group (1523 +/- 705.6 min). There were no significant differences in the routes of delivery. 20.7% of the Cytotec treated patients and 28% of the Oxytocin treated patients required abdominal delivery. CONCLUSIONS: Intravaginal administration of Cytotec appears to be as effective as Oxytocin labor induction.

Administration, Intravaginal↗
PubMed2003

[Peritoneal cyst--a case report].

Peritoneal cysts are rare benign tumors of the abdominal and pelvic peritoneum. We present a case of 26 year old patient with a peritoneal cyst treated operatively.

Adult↗
PubMed2003

[Clinical study of the low dose oral contraceptive novynette].

The authors review the efficacy, control of the menstrual cycle and the tolerance of the low-dosed oral contraceptive Novynette (20 mkg EE/150 desogestrel) of Gedeon Richter at 25 women, included in the study. The results show: Pearl index = 0.00, a good control over the menstrual cycle, not significant and transitor side effects.

Contraceptives, Oral, Combined↗
PubMed2002

[Drug treatment of tubal pregnancy with methotrexate, with an analysis of 5 cases].

The authors present 5 cases of ectopic pregnancy, treated successfully with Methotrexate. Followed are the levels of beta-fraction of human chorionic gonadotropin. Later on, in two of the patients developed intrauterine pregnancy, which terminated successfully with the delivery of healthy term infants.

Abortifacient Agents, Nonsteroidal↗
PubMed2002

[Endometrial hyperplasia--hysteroscopy findings].

Endometrial hyperplasia is considered to be a frequent cause of metrorrhagia. Traditionally diagnosis of this pathology was made on specimens obtained by uterine curettage or after hysterectomy performed for benign diseases. Recently, hysteroscopy has enabled to offer suggestive images of this pathology, in fact it allows to visualize directly the uterine cavity and to perform guided biopsies on the endometrial mucosa. The aim of this study is to evaluate the reliability of the hysteroscopy procedures in the diagnosis of the endometrial hyperplasia. 479 panoramic hysteroscopies were performed in a four-year period for different indications and we found endometrial hyperplasia in 129 patients. We compared the results with the histological findings. On the base be able the possible diagnose and the follow-up procedure for endometrial hyperplasia.

Endometrial Hyperplasia↗
PubMed2002

[Our first experience with the flexible office hysteroscopy].

Authors analyzed 200 women with the help of flexible office hysteroscopy without anaesthesia and cervical dilatation in ambulatoric conditions. Basic purpose of this scientific checkout is to estimate diagnostic value of the method and also the ability of application in out of hospital net. 194 cases of all ware successfully having in mind that all investigations were carries out without previous premedication and anaesthesia. As a result of this first attempt using this method authors can conclude that flexible office hysteroscopy is highly sensitive, specific, harmless and tolerable method.

Adolescent↗
PubMed2002

[Hysteroscopic findings in women with abnormal uterine bleeding according to the materials from the department of obstetrics and gynecology, medical university--Plovdiv].

The results of a four-year period are analyzed. For this time 479 diagnostic panoramic hysteroscopies were performed. By 152 patients (31.7%) the main complaint was abnormal uterine bleeding. All hysteroscopies were followed by histological examination. The specimens have been taken by target biopsy and curretage. The age of the patients ranged from 40 to 75 years. Pointed is a frequency of this pathology and its distribution by age. The authors show the priority of the diagnostic panoramic hysteroscopy in consideration with the other methods of investigation--D & C and sonography, in fact-exactly diagnosis and avoiding unnecessary curretage.

Adult↗
PubMed2001

[Our experience in the treatment of climacteric complaints with Livial (Organon)].

The authors are sharing their experience in using a new medicine Livial (Organon) for the treatment of climacteric complaints. Twenty women have been included in the study. They have received one tablet of 2.5 mg Livial daily throughout four cycles of 28 days. All women report decrease of climacteric symptoms, especially hot flushes and night sweats. Only one of them had genital bleeding while using the drug. Twenty percent of the women reported adverse effects (breast tenderness and nausea), which turned out to be transitional. Conclusions concerning the usage of Livial in the treatment of climacteric complaints have been made.

Anabolic Agents↗