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Biomedical subjects

N Miyagi

Publications and source records attributed to N Miyagi.

44 records · Page 3Linked to original sources
PubMed1978

Heterotransplantation into nude mice of pancreatic carcinoma induced by N-bis(2-hydroxypropyl)nitrosamine in hamsters.

Heterotransplantation into nude mice by the subcutaneous (s.c.) and intraperitoneal (i.p.) routes of hamster pancreatic ductal cell carcinomas induced by N-bis(2-hydroxypropyl)nitrosamine (DHPN) was studied. By s.c. transplantation, tumors occurred in 1 of 4 mice at the first trial, and the tumor incidence was 100% for shorter periods by serial transfer. By i.p. transplantation, the malignant potential of hamster pancreatic ductal cell carcinoma was expressed as intra-abdominal invasive tumors with bloody ascites (carcinomatous peritonitis). Tumors in nude mice basically retained the histology of the original hamster pancreatic ductal cell carcinoma.

Animals↗
PubMedDate not supplied

MR imaging of the brain in patients with mucopolysaccharidosis.

MR imaging of the brain was performed in eight patients with mucopolysaccharidosis (MPS). Two had MPS I S, one had MPS IIA, two had MPS IIB, two had MPS IIIB, and one had MPS VI. In the patients with MPS IIA and MPS VI, T1 and T2 were prolonged in various areas of the cerebral white matter. These findings seemed to correspond with the development of pathologic changes in MPS, such as perivascular pits in the white matter observed on slices of the fixed brain. In the patients with MPS IIA and MPS IIIB, the white matter did not show the proper signal intensity, which suggested that myelination was insufficient and that infiltration or deposition of glycosaminoglycan had occurred; this was consistent with the association of these two types with mental retardation. In the patients with MPS I S, no intracranial abnormalities were detected on MR images. MR imaging of the brain may be used to obtain a differential diagnosis of the various types of MPS, to estimate the extent of mental retardation, and to monitor the progress of this disease.

Atrophy↗
PubMedDate not supplied

Onset of ossification of the tarsal bones in congenital clubfoot.

Subjects of this study were 45 patients with 56 idiopathic congenital clubfeet (34 boys with 42 feet and 11 girls with 14 feet) who underwent successful conservative treatment. Radiologic examinations were performed at intervals of 3 months. In anteroposterior radiographs of bilateral feet, the period of appearance of the ossification center was observed for the first, second, and third cuneiform and the tarsal navicular. The ossification of the tarsal bones in the congenital clubfeet occurred later than that in the unaffected feet in boys. The difference between the clubfeet and the unaffected feet was particularly statistically significant for the tarsal navicular and the second cuneiform (p < 0.01). The tarsal naviculars, the first cuneiforms, and the second cuneiforms in clubfeet and in unaffected feet started to be ossified significantly earlier in girls than in boys. Ossification occurred out of order in three of 56 clubfeet and three of 34 unaffected feet.

Age of Onset↗
PubMedDate not supplied

Fibroblast growth factor-9 (glia-activating factor) stimulates proliferation and production of glial fibrillary acidic protein in human gliomas either in the presence or in the absence of the endogenous growth factor expression.

We tested fibroblast growth factor-9 (FGF-9) expression in human glioma cells (U251MG, T98G, U87MG, KALS-1, NMC-G1) and only NMC-G1 expressed endogenous FGF-9. All cells expressed bFGF and high affinity receptors for FGFs (FGFR1 and FGFR3). Exogenously supplied bFGF and FGF-9 both showed mitogenic activities in all cells. Neutralizing antibody against bFGF inhibited the proliferation in U251MG and NMC-G1, however that against FGF-9 inhibited the proliferation only in NMC-G1. GFAP expression was stimulated by both FGFs in these cells. FGF-9 potentially regulates proliferation and GFAP expression in human gliomas either in the presence or in the absence of the endogenous growth factor expression.

Antibodies, Monoclonal↗